Genetic and pharmacological suppression of oncogenic mutations in RAS genes of yeast and humans

The activity of an oncoprotein and the secretion of a pheromone can be affected by an unusual protein modification. Specifically, posttranslational modification of yeast a-factor and Ras protein requires an intermediate of the cholesterol biosynthetic pathway. This modification is apparently essenti...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1989-07, Vol.245 (4916), p.379-385
Hauptverfasser:	Schafer, W.R. (University of California, Berkeley, CA.), Kim, R, Sterne, R, Thorner, J, Kim, S.H, Rine, J
Format:	Artikel
Sprache:	eng
Schlagworte:	550300 - Cytology ACIDE ORGANIQUE ACIDOS ORGANICOS Alleles Amino Acid Sequence Amino acids Animals BASIC BIOLOGICAL SCIENCES Biological and medical sciences BIOSYNTHESIS Cell growth Cell lines Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cells, Cultured CHOLESTEROL DATA Drosophila Electrophoresis, Polyacrylamide Gel EUMYCOTA EXPERIMENTAL DATA Fundamental and applied biological sciences. Psychology Fungal Proteins - genetics Fungal Proteins - metabolism FUNGI GENE GENES Genes, ras Genetic aspects Genetic mutation Genetics Humans HYDROXY COMPOUNDS Hydroxymethylglutaryl CoA Reductases - genetics Hydroxymethylglutaryl-CoA Synthase - genetics Immunoblotting INFORMATION LIPIDE LIPIDOS Mating Factor Mevalonic Acid - biosynthesis MICROORGANISMS Molecular and cellular biology Molecular Sequence Data MUTACION MUTATION Mutation (Biology) MUTATIONS NUCLEOTIDE NUCLEOTIDOS NUMERICAL DATA ONCOGENES Oncogenic viruses Oocytes ORGANIC COMPOUNDS Peptides - genetics Peptides - metabolism PHEROMONE PLANTS Precipitin Tests Protein Processing, Post-Translational Protein research PROTEINAS AGLUTINANTES PROTEINE DE LIAISON PROTEINS Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins p21(ras) ras genes ras Proteins SACCHAROMYCES CEREVISIAE Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - physiology Saccharomyces cerevisiae Proteins SECRETION Steepest descent method STEROIDS STEROLS Suppression, Genetic SYNTHESIS Xenopus Yeast fungi YEASTS Yeasts (Fungi)
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