Ultraviolet stimulated melanogenesis by human melanocytes is augmented by di-acyl glycerol but not TPA

Epidermal melanocytes (MC) synthesise melanin in response to ultraviolet radiation (UVR). The mechanisms mediating the UV‐induced activation of melano‐genesis are unknown but since UVR induces turnover of membrane phospholipids generating prostaglandins (PGs) and other products, it is possible that...

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Veröffentlicht in:	Journal of cellular physiology 1990-02, Vol.142 (2), p.334-341
Hauptverfasser:	Friedmann, P. S., Wren, F. E., Matthews, J. N. S.
Format:	Artikel
Sprache:	eng
Schlagworte:	560120 - Radiation Effects on Biochemicals, Cells, & Tissue Culture 560300 - Chemicals Metabolism & Toxicology ALCOHOLS Alprostadil - pharmacology ANIMAL CELLS ANIMAL TISSUES ANIMALS Biological and medical sciences BIOLOGICAL EFFECTS BIOLOGICAL RADIATION EFFECTS BIOSYNTHESIS BODY CARCINOGENS CELL DIVISION Cell Division - drug effects Cell physiology Diglycerides - pharmacology Dinoprost - pharmacology Dinoprostone - pharmacology DISEASES DOSE-RESPONSE RELATIONSHIPS ELECTROMAGNETIC RADIATION ENZYME ACTIVITY ENZYMES EPIDERMIS EPITHELIUM ESTERS Fundamental and applied biological sciences. Psychology Glycerides - pharmacology GLYCEROL Humans HYDROXY COMPOUNDS Male MAMMALS MAN MELANIN Melanins - biosynthesis Melanocytes - drug effects Melanocytes - metabolism Melanocytes - radiation effects Melanoma, Experimental MELANOMAS MICE Molecular and cellular biology NEOPLASMS ORGANIC COMPOUNDS ORGANIC NITROGEN COMPOUNDS ORGANS PHORBOL ESTERS PHOSPHORUS-GROUP TRANSFERASES PHOSPHOTRANSFERASES PIGMENTS PRIMATES Prostaglandin D2 - pharmacology PROSTAGLANDINS RADIATION EFFECTS RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RADIATIONS RADIOSENSITIVITY EFFECTS RODENTS Signal transduction SKIN SYNTHESIS Tetradecanoylphorbol Acetate - pharmacology TISSUES TRANSFERASES TUMOR CELLS Tumor Cells, Cultured ULTRAVIOLET RADIATION Ultraviolet Rays VERTEBRATES
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