Ultraviolet stimulated melanogenesis by human melanocytes is augmented by di-acyl glycerol but not TPA
Epidermal melanocytes (MC) synthesise melanin in response to ultraviolet radiation (UVR). The mechanisms mediating the UV‐induced activation of melano‐genesis are unknown but since UVR induces turnover of membrane phospholipids generating prostaglandins (PGs) and other products, it is possible that...
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| Veröffentlicht in: | Journal of cellular physiology 1990-02, Vol.142 (2), p.334-341 |
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| creator | Friedmann, P. S. Wren, F. E. Matthews, J. N. S. |
| description | Epidermal melanocytes (MC) synthesise melanin in response to ultraviolet radiation (UVR). The mechanisms mediating the UV‐induced activation of melano‐genesis are unknown but since UVR induces turnover of membrane phospholipids generating prostaglandins (PGs) and other products, it is possible that one of these might provide the activating signal. We have examined the effects of prostaglandins (PGs) E1, E2, D2, F2α, and di‐acyl glycerol upon the UV‐induced responses of cultured human MC and the Cloudman S91 melanoma cell line. The PGs had little effect on unirradliated cells and did not alter the response to UVR in either human MC or S91 melanoma cells. However, a synthetic analogue of di‐acyl glycerol, 1‐oleyl 2‐acetyl glycerol (OAG), caused a significant (P |
| doi_str_mv | 10.1002/jcp.1041420216 |
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S. ; Wren, F. E. ; Matthews, J. N. S.</creator><creatorcontrib>Friedmann, P. S. ; Wren, F. E. ; Matthews, J. N. S.</creatorcontrib><description>Epidermal melanocytes (MC) synthesise melanin in response to ultraviolet radiation (UVR). The mechanisms mediating the UV‐induced activation of melano‐genesis are unknown but since UVR induces turnover of membrane phospholipids generating prostaglandins (PGs) and other products, it is possible that one of these might provide the activating signal. We have examined the effects of prostaglandins (PGs) E1, E2, D2, F2α, and di‐acyl glycerol upon the UV‐induced responses of cultured human MC and the Cloudman S91 melanoma cell line. The PGs had little effect on unirradliated cells and did not alter the response to UVR in either human MC or S91 melanoma cells. However, a synthetic analogue of di‐acyl glycerol, 1‐oleyl 2‐acetyl glycerol (OAG), caused a significant (P<0.0001), dose‐related augmentation of melanin content both in human MC (seven‐fold) and S91 cells (three‐fold). UVR caused a significant augmentation of the OAG‐induced melanognesis of both human MC and S91 cells. Since OAG is known to activate protein kinase C, it was possible that the observed modulation of the UVR signal could be via that pathway. Di‐octanoyl glycerol, another di‐acyl glycerol, which activates kinase C, caused a small (70%) increase in melanogenesis in MC which was not altered by UVR. However, 12‐0 tetradecanoyl phorbol 13‐acetate (TPA), a potent activator of protein kinase C, had no significant effect on either basal or UV‐induced melanin synthesis in either cell type. These data suggest that the UV‐induced signal activating melanogenesis could be mediated by di‐acyl glycerol. Furthermore, they imply that the signal is transduced via an alternative, pathway that might be independent of protein kinase C.</description><identifier>ISSN: 0021-9541</identifier><identifier>EISSN: 1097-4652</identifier><identifier>DOI: 10.1002/jcp.1041420216</identifier><identifier>PMID: 2303529</identifier><identifier>CODEN: JCLLAX</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>560120 - Radiation Effects on Biochemicals, Cells, & Tissue Culture ; 560300 - Chemicals Metabolism & Toxicology ; ALCOHOLS ; Alprostadil - pharmacology ; ANIMAL CELLS ; ANIMAL TISSUES ; ANIMALS ; Biological and medical sciences ; BIOLOGICAL EFFECTS ; BIOLOGICAL RADIATION EFFECTS ; BIOSYNTHESIS ; BODY ; CARCINOGENS ; CELL DIVISION ; Cell Division - drug effects ; Cell physiology ; Diglycerides - pharmacology ; Dinoprost - pharmacology ; Dinoprostone - pharmacology ; DISEASES ; DOSE-RESPONSE RELATIONSHIPS ; ELECTROMAGNETIC RADIATION ; ENZYME ACTIVITY ; ENZYMES ; EPIDERMIS ; EPITHELIUM ; ESTERS ; Fundamental and applied biological sciences. Psychology ; Glycerides - pharmacology ; GLYCEROL ; Humans ; HYDROXY COMPOUNDS ; Male ; MAMMALS ; MAN ; MELANIN ; Melanins - biosynthesis ; Melanocytes - drug effects ; Melanocytes - metabolism ; Melanocytes - radiation effects ; Melanoma, Experimental ; MELANOMAS ; MICE ; Molecular and cellular biology ; NEOPLASMS ; ORGANIC COMPOUNDS ; ORGANIC NITROGEN COMPOUNDS ; ORGANS ; PHORBOL ESTERS ; PHOSPHORUS-GROUP TRANSFERASES ; PHOSPHOTRANSFERASES ; PIGMENTS ; PRIMATES ; Prostaglandin D2 - pharmacology ; PROSTAGLANDINS ; RADIATION EFFECTS ; RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT ; RADIATIONS ; RADIOSENSITIVITY EFFECTS ; RODENTS ; Signal transduction ; SKIN ; SYNTHESIS ; Tetradecanoylphorbol Acetate - pharmacology ; TISSUES ; TRANSFERASES ; TUMOR CELLS ; Tumor Cells, Cultured ; ULTRAVIOLET RADIATION ; Ultraviolet Rays ; VERTEBRATES</subject><ispartof>Journal of cellular physiology, 1990-02, Vol.142 (2), p.334-341</ispartof><rights>Copyright © 1990 Wiley‐Liss, Inc.</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4356-976a1a2c248ada4f49987bb5ea7151534767eda6343dc3f6a92ed98ea99d55743</citedby><cites>FETCH-LOGICAL-c4356-976a1a2c248ada4f49987bb5ea7151534767eda6343dc3f6a92ed98ea99d55743</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjcp.1041420216$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjcp.1041420216$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19619029$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2303529$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/7190005$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Friedmann, P. S.</creatorcontrib><creatorcontrib>Wren, F. E.</creatorcontrib><creatorcontrib>Matthews, J. N. S.</creatorcontrib><title>Ultraviolet stimulated melanogenesis by human melanocytes is augmented by di-acyl glycerol but not TPA</title><title>Journal of cellular physiology</title><addtitle>J. Cell. Physiol</addtitle><description>Epidermal melanocytes (MC) synthesise melanin in response to ultraviolet radiation (UVR). The mechanisms mediating the UV‐induced activation of melano‐genesis are unknown but since UVR induces turnover of membrane phospholipids generating prostaglandins (PGs) and other products, it is possible that one of these might provide the activating signal. We have examined the effects of prostaglandins (PGs) E1, E2, D2, F2α, and di‐acyl glycerol upon the UV‐induced responses of cultured human MC and the Cloudman S91 melanoma cell line. The PGs had little effect on unirradliated cells and did not alter the response to UVR in either human MC or S91 melanoma cells. However, a synthetic analogue of di‐acyl glycerol, 1‐oleyl 2‐acetyl glycerol (OAG), caused a significant (P<0.0001), dose‐related augmentation of melanin content both in human MC (seven‐fold) and S91 cells (three‐fold). UVR caused a significant augmentation of the OAG‐induced melanognesis of both human MC and S91 cells. Since OAG is known to activate protein kinase C, it was possible that the observed modulation of the UVR signal could be via that pathway. Di‐octanoyl glycerol, another di‐acyl glycerol, which activates kinase C, caused a small (70%) increase in melanogenesis in MC which was not altered by UVR. However, 12‐0 tetradecanoyl phorbol 13‐acetate (TPA), a potent activator of protein kinase C, had no significant effect on either basal or UV‐induced melanin synthesis in either cell type. These data suggest that the UV‐induced signal activating melanogenesis could be mediated by di‐acyl glycerol. Furthermore, they imply that the signal is transduced via an alternative, pathway that might be independent of protein kinase C.</description><subject>560120 - Radiation Effects on Biochemicals, Cells, & Tissue Culture</subject><subject>560300 - Chemicals Metabolism & Toxicology</subject><subject>ALCOHOLS</subject><subject>Alprostadil - pharmacology</subject><subject>ANIMAL CELLS</subject><subject>ANIMAL TISSUES</subject><subject>ANIMALS</subject><subject>Biological and medical sciences</subject><subject>BIOLOGICAL EFFECTS</subject><subject>BIOLOGICAL RADIATION EFFECTS</subject><subject>BIOSYNTHESIS</subject><subject>BODY</subject><subject>CARCINOGENS</subject><subject>CELL DIVISION</subject><subject>Cell Division - drug effects</subject><subject>Cell physiology</subject><subject>Diglycerides - pharmacology</subject><subject>Dinoprost - pharmacology</subject><subject>Dinoprostone - pharmacology</subject><subject>DISEASES</subject><subject>DOSE-RESPONSE RELATIONSHIPS</subject><subject>ELECTROMAGNETIC RADIATION</subject><subject>ENZYME ACTIVITY</subject><subject>ENZYMES</subject><subject>EPIDERMIS</subject><subject>EPITHELIUM</subject><subject>ESTERS</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glycerides - pharmacology</subject><subject>GLYCEROL</subject><subject>Humans</subject><subject>HYDROXY COMPOUNDS</subject><subject>Male</subject><subject>MAMMALS</subject><subject>MAN</subject><subject>MELANIN</subject><subject>Melanins - biosynthesis</subject><subject>Melanocytes - drug effects</subject><subject>Melanocytes - metabolism</subject><subject>Melanocytes - radiation effects</subject><subject>Melanoma, Experimental</subject><subject>MELANOMAS</subject><subject>MICE</subject><subject>Molecular and cellular biology</subject><subject>NEOPLASMS</subject><subject>ORGANIC COMPOUNDS</subject><subject>ORGANIC NITROGEN COMPOUNDS</subject><subject>ORGANS</subject><subject>PHORBOL ESTERS</subject><subject>PHOSPHORUS-GROUP TRANSFERASES</subject><subject>PHOSPHOTRANSFERASES</subject><subject>PIGMENTS</subject><subject>PRIMATES</subject><subject>Prostaglandin D2 - pharmacology</subject><subject>PROSTAGLANDINS</subject><subject>RADIATION EFFECTS</subject><subject>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</subject><subject>RADIATIONS</subject><subject>RADIOSENSITIVITY EFFECTS</subject><subject>RODENTS</subject><subject>Signal transduction</subject><subject>SKIN</subject><subject>SYNTHESIS</subject><subject>Tetradecanoylphorbol Acetate - pharmacology</subject><subject>TISSUES</subject><subject>TRANSFERASES</subject><subject>TUMOR CELLS</subject><subject>Tumor Cells, Cultured</subject><subject>ULTRAVIOLET RADIATION</subject><subject>Ultraviolet Rays</subject><subject>VERTEBRATES</subject><issn>0021-9541</issn><issn>1097-4652</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1v1DAQhi0EKkvhyg0pQuKY4m-vj2WB8lFBK22FxMWaOJNtipOsYgfIv8clq1acONmaed4Z-yHkOaMnjFL--sbv80UyySln-gFZMWpNKbXiD8kqA6y0SrLH5EmMN5RSa4U4IkdcUKG4XZHmKqQRfrZDwFTE1HZTgIR10WGAfthhj7GNRTUX11MH_aHs54SxyHWYdh32t3wm6rYEP4diF2aP4xCKakpFP6Rie3H6lDxqIER8djiPydX7d9vNh_L869nHzel56aVQurRGAwPuuVxDDbKR1q5NVSkEwxRTQhptsAYtpKi9aDRYjrVdI1hbK2WkOCYvl7lD_ouLvk3or_3Q9-iTM8xmAypDJwvkxyHGERu3H9sOxtkx6m6luizV3UvNgRdLYD9VHdZ3-MFi7r869CF6CM0IvW_j_VSr8-a_nF24X23A-T9b3afNxT9vKJdsGxP-vsvC-MNpI4xy376cue-Kv3m7_XzpLsUfRxSfhQ</recordid><startdate>199002</startdate><enddate>199002</enddate><creator>Friedmann, P. S.</creator><creator>Wren, F. E.</creator><creator>Matthews, J. N. S.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>OTOTI</scope></search><sort><creationdate>199002</creationdate><title>Ultraviolet stimulated melanogenesis by human melanocytes is augmented by di-acyl glycerol but not TPA</title><author>Friedmann, P. S. ; Wren, F. E. ; Matthews, J. N. S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4356-976a1a2c248ada4f49987bb5ea7151534767eda6343dc3f6a92ed98ea99d55743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>560120 - Radiation Effects on Biochemicals, Cells, & Tissue Culture</topic><topic>560300 - Chemicals Metabolism & Toxicology</topic><topic>ALCOHOLS</topic><topic>Alprostadil - pharmacology</topic><topic>ANIMAL CELLS</topic><topic>ANIMAL TISSUES</topic><topic>ANIMALS</topic><topic>Biological and medical sciences</topic><topic>BIOLOGICAL EFFECTS</topic><topic>BIOLOGICAL RADIATION EFFECTS</topic><topic>BIOSYNTHESIS</topic><topic>BODY</topic><topic>CARCINOGENS</topic><topic>CELL DIVISION</topic><topic>Cell Division - drug effects</topic><topic>Cell physiology</topic><topic>Diglycerides - pharmacology</topic><topic>Dinoprost - pharmacology</topic><topic>Dinoprostone - pharmacology</topic><topic>DISEASES</topic><topic>DOSE-RESPONSE RELATIONSHIPS</topic><topic>ELECTROMAGNETIC RADIATION</topic><topic>ENZYME ACTIVITY</topic><topic>ENZYMES</topic><topic>EPIDERMIS</topic><topic>EPITHELIUM</topic><topic>ESTERS</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glycerides - pharmacology</topic><topic>GLYCEROL</topic><topic>Humans</topic><topic>HYDROXY COMPOUNDS</topic><topic>Male</topic><topic>MAMMALS</topic><topic>MAN</topic><topic>MELANIN</topic><topic>Melanins - biosynthesis</topic><topic>Melanocytes - drug effects</topic><topic>Melanocytes - metabolism</topic><topic>Melanocytes - radiation effects</topic><topic>Melanoma, Experimental</topic><topic>MELANOMAS</topic><topic>MICE</topic><topic>Molecular and cellular biology</topic><topic>NEOPLASMS</topic><topic>ORGANIC COMPOUNDS</topic><topic>ORGANIC NITROGEN COMPOUNDS</topic><topic>ORGANS</topic><topic>PHORBOL ESTERS</topic><topic>PHOSPHORUS-GROUP TRANSFERASES</topic><topic>PHOSPHOTRANSFERASES</topic><topic>PIGMENTS</topic><topic>PRIMATES</topic><topic>Prostaglandin D2 - pharmacology</topic><topic>PROSTAGLANDINS</topic><topic>RADIATION EFFECTS</topic><topic>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</topic><topic>RADIATIONS</topic><topic>RADIOSENSITIVITY EFFECTS</topic><topic>RODENTS</topic><topic>Signal transduction</topic><topic>SKIN</topic><topic>SYNTHESIS</topic><topic>Tetradecanoylphorbol Acetate - pharmacology</topic><topic>TISSUES</topic><topic>TRANSFERASES</topic><topic>TUMOR CELLS</topic><topic>Tumor Cells, Cultured</topic><topic>ULTRAVIOLET RADIATION</topic><topic>Ultraviolet Rays</topic><topic>VERTEBRATES</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Friedmann, P. S.</creatorcontrib><creatorcontrib>Wren, F. E.</creatorcontrib><creatorcontrib>Matthews, J. N. S.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>OSTI.GOV</collection><jtitle>Journal of cellular physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Friedmann, P. S.</au><au>Wren, F. E.</au><au>Matthews, J. N. S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ultraviolet stimulated melanogenesis by human melanocytes is augmented by di-acyl glycerol but not TPA</atitle><jtitle>Journal of cellular physiology</jtitle><addtitle>J. Cell. Physiol</addtitle><date>1990-02</date><risdate>1990</risdate><volume>142</volume><issue>2</issue><spage>334</spage><epage>341</epage><pages>334-341</pages><issn>0021-9541</issn><eissn>1097-4652</eissn><coden>JCLLAX</coden><abstract>Epidermal melanocytes (MC) synthesise melanin in response to ultraviolet radiation (UVR). The mechanisms mediating the UV‐induced activation of melano‐genesis are unknown but since UVR induces turnover of membrane phospholipids generating prostaglandins (PGs) and other products, it is possible that one of these might provide the activating signal. We have examined the effects of prostaglandins (PGs) E1, E2, D2, F2α, and di‐acyl glycerol upon the UV‐induced responses of cultured human MC and the Cloudman S91 melanoma cell line. The PGs had little effect on unirradliated cells and did not alter the response to UVR in either human MC or S91 melanoma cells. However, a synthetic analogue of di‐acyl glycerol, 1‐oleyl 2‐acetyl glycerol (OAG), caused a significant (P<0.0001), dose‐related augmentation of melanin content both in human MC (seven‐fold) and S91 cells (three‐fold). UVR caused a significant augmentation of the OAG‐induced melanognesis of both human MC and S91 cells. Since OAG is known to activate protein kinase C, it was possible that the observed modulation of the UVR signal could be via that pathway. Di‐octanoyl glycerol, another di‐acyl glycerol, which activates kinase C, caused a small (70%) increase in melanogenesis in MC which was not altered by UVR. However, 12‐0 tetradecanoyl phorbol 13‐acetate (TPA), a potent activator of protein kinase C, had no significant effect on either basal or UV‐induced melanin synthesis in either cell type. These data suggest that the UV‐induced signal activating melanogenesis could be mediated by di‐acyl glycerol. Furthermore, they imply that the signal is transduced via an alternative, pathway that might be independent of protein kinase C.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>2303529</pmid><doi>10.1002/jcp.1041420216</doi><tpages>8</tpages></addata></record> |
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| ispartof | Journal of cellular physiology, 1990-02, Vol.142 (2), p.334-341 |
| issn | 0021-9541 1097-4652 |
| language | eng |
| recordid | cdi_osti_scitechconnect_7190005 |
| source | MEDLINE; Wiley Journals |
| subjects | 560120 - Radiation Effects on Biochemicals, Cells, & Tissue Culture 560300 - Chemicals Metabolism & Toxicology ALCOHOLS Alprostadil - pharmacology ANIMAL CELLS ANIMAL TISSUES ANIMALS Biological and medical sciences BIOLOGICAL EFFECTS BIOLOGICAL RADIATION EFFECTS BIOSYNTHESIS BODY CARCINOGENS CELL DIVISION Cell Division - drug effects Cell physiology Diglycerides - pharmacology Dinoprost - pharmacology Dinoprostone - pharmacology DISEASES DOSE-RESPONSE RELATIONSHIPS ELECTROMAGNETIC RADIATION ENZYME ACTIVITY ENZYMES EPIDERMIS EPITHELIUM ESTERS Fundamental and applied biological sciences. Psychology Glycerides - pharmacology GLYCEROL Humans HYDROXY COMPOUNDS Male MAMMALS MAN MELANIN Melanins - biosynthesis Melanocytes - drug effects Melanocytes - metabolism Melanocytes - radiation effects Melanoma, Experimental MELANOMAS MICE Molecular and cellular biology NEOPLASMS ORGANIC COMPOUNDS ORGANIC NITROGEN COMPOUNDS ORGANS PHORBOL ESTERS PHOSPHORUS-GROUP TRANSFERASES PHOSPHOTRANSFERASES PIGMENTS PRIMATES Prostaglandin D2 - pharmacology PROSTAGLANDINS RADIATION EFFECTS RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RADIATIONS RADIOSENSITIVITY EFFECTS RODENTS Signal transduction SKIN SYNTHESIS Tetradecanoylphorbol Acetate - pharmacology TISSUES TRANSFERASES TUMOR CELLS Tumor Cells, Cultured ULTRAVIOLET RADIATION Ultraviolet Rays VERTEBRATES |
| title | Ultraviolet stimulated melanogenesis by human melanocytes is augmented by di-acyl glycerol but not TPA |
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