The interaction between nitrogen oxides and hemoglobin and endothelium-derived relaxing factor

Among nitrogen oxides, NO and NO 2 are free radicals and show a variety of biological effects. NO 2 is a strongly oxidizing toxicant, although NO, not oxidizing as NO 2, is toxic in that it interacts with hemoglobin to form nitrosyl-and methemoglobin. Nitrosylhemoglobin shows a characteristic electr...

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Veröffentlicht in:	Free Radical Biology and Medicine 1989, Vol.7 (6), p.653-658
Hauptverfasser:	Kosaka, Hiroaki, Uozumi, Mitsuro, Tyuma, Itiro
Format:	Artikel
Sprache:	eng
Schlagworte:	560300 - Chemicals Metabolism & Toxicology ANIMAL TISSUES BIOCHEMICAL REACTION KINETICS Biological and medical sciences BIOLOGICAL MATERIALS BLOOD BLOOD CELLS BODY BODY FLUIDS CARBOXYLIC ACIDS CHALCOGENIDES DOCUMENT TYPES ELECTRON SPIN RESONANCE ENDOTHELIUM Endothelium-derived relaxing factor ERYTHROCYTES ESR Free Radicals Fundamental and applied biological sciences. Psychology GLOBINS HEMOGLOBIN Hemoglobins HETEROCYCLIC ACIDS HETEROCYCLIC COMPOUNDS Humans KINETICS MAGNETIC RESONANCE MATERIALS Mechanisms. Catalysis. Electron transfer. Models METABOLISM Molecular biophysics NITRIC OXIDE Nitrite NITROGEN COMPOUNDS NITROGEN DIOXIDE NITROGEN OXIDES NO 2 ORGANIC ACIDS ORGANIC COMPOUNDS ORGANIC NITROGEN COMPOUNDS OXIDES OXYGEN COMPOUNDS Physical chemistry in biology PIGMENTS PORPHYRINS PROTEINS RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RADICALS REACTION KINETICS RESONANCE REVIEWS STOICHIOMETRY Superoxide Superoxides TISSUES TOXICITY
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