Sensitivity of the sodium efflux in single barnacle muscle fibers to the microinjection of aluminum
A study has been made of the behavior of the Na efflux in single muscle fibers from the barnacle, Balanus nubilus, toward the microinjection of AlCl 3. The effect of microinjecting AlCl 3 is either biphasic with inhibition following transitory stimulation, or monophasic with inhibition occurring pro...
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| Veröffentlicht in: | Toxicology and applied pharmacology 1990, Vol.102 (1), p.174-185 |
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| creator | Bittar, E.Edward Nwoga, Jude Huang, Yong-Ping |
| description | A study has been made of the behavior of the Na efflux in single muscle fibers from the barnacle,
Balanus nubilus, toward the microinjection of AlCl
3. The effect of microinjecting AlCl
3 is either biphasic with inhibition following transitory stimulation, or monophasic with inhibition occurring promptly and taking about 1 hr to reach a maximum. The magnitude of the inhibition is dose dependent and the minimally effective concentration is 10 m
m. This is diluted by the myoplasm by a factor of roughly 100. Fibers injected with 1
m AlCl
3 are found to be insensitive to 10
−4
m ouabain, whereas fibers injected with 0.5
m AlCl
3 show a further fall in Na efflux, which is smaller than that seen in control fibers. The response of the ouabain-insensitive Na efflux to the injection of 0.5
m AlCl
3 is biphasic: stimulation is followed by inhibition. The stimulatory phase is largely dependent on the presence of external Ca
2+ and is reversed by the sudden omission of Ca
2+ from the bathing medium. Fibers also injected with 0.5
m AlCl
3 show a marked reduction in the response of the Na efflux to high external K. Injection of ATPMg before or after the injection of AlCl
3 fails in most instances to abolish or reverse the inhibitory effect. By contrast, fibers preinjected with deferoxamine show little or no effect following the injection of AlCl
3. However, external application of deferoxamine is ineffective. |
| doi_str_mv | 10.1016/0041-008X(90)90094-B |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_osti_</sourceid><recordid>TN_cdi_osti_scitechconnect_7167276</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>0041008X9090094B</els_id><sourcerecordid>15579597</sourcerecordid><originalsourceid>FETCH-LOGICAL-c444t-e8aae4b38ede10629682d0926caac227f6c7e89a0810cf9c9365eeee12a5166b3</originalsourceid><addsrcrecordid>eNp9kV-L1TAQxYMo63X1GygUEdGH6qRp0-ZFcBf_wYIPKvgW0nTiztImu0m6uN_edO_lPpqXCczvDHPOMPacwzsOXL4HaHkNMPx-o-CtAlBtffaA7TgoWYMQ4iHbHZHH7ElKV7BBLT9hJw3vhODDjtkf6BNluqV8VwVX5UusUphoXSp0bl7_VuSrRP7PjNVooje2fJY1bcXRiDFVOdyrFrIxkL9Cmyn4bZaZ14X8ujxlj5yZEz471FP26_Onn-df64vvX76df7yobdu2ucbBGGxHMeCEHGSj5NBMoBppjbFN0ztpexyUgYGDdcoqITssjzem41KO4pS93M8NKZNOljLaSxu8Lyvpnsu-6WWBXu-h6xhuVkxZL5QszrPxGNakedf1qlN9Ads9WGylFNHp60iLiXeag94OoLd09ZauVqDvD6DPiuzFYf46LjgdRYfES__VoW-SNbOLxltKR0wOUnSSF-zDHsMS2C1h3PygtzhR3OxMgf6_xz9yDqK3</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>15579597</pqid></control><display><type>article</type><title>Sensitivity of the sodium efflux in single barnacle muscle fibers to the microinjection of aluminum</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Bittar, E.Edward ; Nwoga, Jude ; Huang, Yong-Ping</creator><creatorcontrib>Bittar, E.Edward ; Nwoga, Jude ; Huang, Yong-Ping</creatorcontrib><description>A study has been made of the behavior of the Na efflux in single muscle fibers from the barnacle,
Balanus nubilus, toward the microinjection of AlCl
3. The effect of microinjecting AlCl
3 is either biphasic with inhibition following transitory stimulation, or monophasic with inhibition occurring promptly and taking about 1 hr to reach a maximum. The magnitude of the inhibition is dose dependent and the minimally effective concentration is 10 m
m. This is diluted by the myoplasm by a factor of roughly 100. Fibers injected with 1
m AlCl
3 are found to be insensitive to 10
−4
m ouabain, whereas fibers injected with 0.5
m AlCl
3 show a further fall in Na efflux, which is smaller than that seen in control fibers. The response of the ouabain-insensitive Na efflux to the injection of 0.5
m AlCl
3 is biphasic: stimulation is followed by inhibition. The stimulatory phase is largely dependent on the presence of external Ca
2+ and is reversed by the sudden omission of Ca
2+ from the bathing medium. Fibers also injected with 0.5
m AlCl
3 show a marked reduction in the response of the Na efflux to high external K. Injection of ATPMg before or after the injection of AlCl
3 fails in most instances to abolish or reverse the inhibitory effect. By contrast, fibers preinjected with deferoxamine show little or no effect following the injection of AlCl
3. However, external application of deferoxamine is ineffective.</description><identifier>ISSN: 0041-008X</identifier><identifier>EISSN: 1096-0333</identifier><identifier>DOI: 10.1016/0041-008X(90)90094-B</identifier><identifier>PMID: 2153318</identifier><identifier>CODEN: TXAPA9</identifier><language>eng</language><publisher>San Diego, CA: Elsevier Inc</publisher><subject>560300 - Chemicals Metabolism & Toxicology ; ALKALI METALS ; ALUMINIUM ; Aluminum - administration & dosage ; Aluminum - pharmacology ; Aluminum Chloride ; Aluminum Compounds ; ANIMALS ; AQUATIC ORGANISMS ; ARTHROPODS ; Balanus nubilus ; Biological and medical sciences ; BIOLOGICAL EFFECTS ; BIOSYNTHESIS ; Chemical and industrial products toxicology. Toxic occupational diseases ; Chlorides - administration & dosage ; Chlorides - pharmacology ; CRUSTACEANS ; Dose-Response Relationship, Drug ; DOSE-RESPONSE RELATIONSHIPS ; Drug Interactions ; ELEMENTS ; IN VITRO ; In Vitro Techniques ; INVERTEBRATES ; Marine ; Medical sciences ; METALS ; Metals and various inorganic compounds ; Microinjections ; MUSCLES ; Muscles - drug effects ; Muscles - metabolism ; RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT ; SODIUM ; Sodium - metabolism ; Sodium Channels - drug effects ; Sodium Channels - metabolism ; Sodium Radioisotopes ; SYNTHESIS ; Thoracica - drug effects ; Thoracica - metabolism ; Toxicology</subject><ispartof>Toxicology and applied pharmacology, 1990, Vol.102 (1), p.174-185</ispartof><rights>1990</rights><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c444t-e8aae4b38ede10629682d0926caac227f6c7e89a0810cf9c9365eeee12a5166b3</citedby><cites>FETCH-LOGICAL-c444t-e8aae4b38ede10629682d0926caac227f6c7e89a0810cf9c9365eeee12a5166b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0041008X9090094B$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,4010,27900,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6863561$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2153318$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/7167276$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Bittar, E.Edward</creatorcontrib><creatorcontrib>Nwoga, Jude</creatorcontrib><creatorcontrib>Huang, Yong-Ping</creatorcontrib><title>Sensitivity of the sodium efflux in single barnacle muscle fibers to the microinjection of aluminum</title><title>Toxicology and applied pharmacology</title><addtitle>Toxicol Appl Pharmacol</addtitle><description>A study has been made of the behavior of the Na efflux in single muscle fibers from the barnacle,
Balanus nubilus, toward the microinjection of AlCl
3. The effect of microinjecting AlCl
3 is either biphasic with inhibition following transitory stimulation, or monophasic with inhibition occurring promptly and taking about 1 hr to reach a maximum. The magnitude of the inhibition is dose dependent and the minimally effective concentration is 10 m
m. This is diluted by the myoplasm by a factor of roughly 100. Fibers injected with 1
m AlCl
3 are found to be insensitive to 10
−4
m ouabain, whereas fibers injected with 0.5
m AlCl
3 show a further fall in Na efflux, which is smaller than that seen in control fibers. The response of the ouabain-insensitive Na efflux to the injection of 0.5
m AlCl
3 is biphasic: stimulation is followed by inhibition. The stimulatory phase is largely dependent on the presence of external Ca
2+ and is reversed by the sudden omission of Ca
2+ from the bathing medium. Fibers also injected with 0.5
m AlCl
3 show a marked reduction in the response of the Na efflux to high external K. Injection of ATPMg before or after the injection of AlCl
3 fails in most instances to abolish or reverse the inhibitory effect. By contrast, fibers preinjected with deferoxamine show little or no effect following the injection of AlCl
3. However, external application of deferoxamine is ineffective.</description><subject>560300 - Chemicals Metabolism & Toxicology</subject><subject>ALKALI METALS</subject><subject>ALUMINIUM</subject><subject>Aluminum - administration & dosage</subject><subject>Aluminum - pharmacology</subject><subject>Aluminum Chloride</subject><subject>Aluminum Compounds</subject><subject>ANIMALS</subject><subject>AQUATIC ORGANISMS</subject><subject>ARTHROPODS</subject><subject>Balanus nubilus</subject><subject>Biological and medical sciences</subject><subject>BIOLOGICAL EFFECTS</subject><subject>BIOSYNTHESIS</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>Chlorides - administration & dosage</subject><subject>Chlorides - pharmacology</subject><subject>CRUSTACEANS</subject><subject>Dose-Response Relationship, Drug</subject><subject>DOSE-RESPONSE RELATIONSHIPS</subject><subject>Drug Interactions</subject><subject>ELEMENTS</subject><subject>IN VITRO</subject><subject>In Vitro Techniques</subject><subject>INVERTEBRATES</subject><subject>Marine</subject><subject>Medical sciences</subject><subject>METALS</subject><subject>Metals and various inorganic compounds</subject><subject>Microinjections</subject><subject>MUSCLES</subject><subject>Muscles - drug effects</subject><subject>Muscles - metabolism</subject><subject>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</subject><subject>SODIUM</subject><subject>Sodium - metabolism</subject><subject>Sodium Channels - drug effects</subject><subject>Sodium Channels - metabolism</subject><subject>Sodium Radioisotopes</subject><subject>SYNTHESIS</subject><subject>Thoracica - drug effects</subject><subject>Thoracica - metabolism</subject><subject>Toxicology</subject><issn>0041-008X</issn><issn>1096-0333</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kV-L1TAQxYMo63X1GygUEdGH6qRp0-ZFcBf_wYIPKvgW0nTiztImu0m6uN_edO_lPpqXCczvDHPOMPacwzsOXL4HaHkNMPx-o-CtAlBtffaA7TgoWYMQ4iHbHZHH7ElKV7BBLT9hJw3vhODDjtkf6BNluqV8VwVX5UusUphoXSp0bl7_VuSrRP7PjNVooje2fJY1bcXRiDFVOdyrFrIxkL9Cmyn4bZaZ14X8ujxlj5yZEz471FP26_Onn-df64vvX76df7yobdu2ucbBGGxHMeCEHGSj5NBMoBppjbFN0ztpexyUgYGDdcoqITssjzem41KO4pS93M8NKZNOljLaSxu8Lyvpnsu-6WWBXu-h6xhuVkxZL5QszrPxGNakedf1qlN9Ads9WGylFNHp60iLiXeag94OoLd09ZauVqDvD6DPiuzFYf46LjgdRYfES__VoW-SNbOLxltKR0wOUnSSF-zDHsMS2C1h3PygtzhR3OxMgf6_xz9yDqK3</recordid><startdate>1990</startdate><enddate>1990</enddate><creator>Bittar, E.Edward</creator><creator>Nwoga, Jude</creator><creator>Huang, Yong-Ping</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T2</scope><scope>7TV</scope><scope>7U2</scope><scope>7U7</scope><scope>C1K</scope><scope>F1W</scope><scope>H95</scope><scope>H97</scope><scope>L.G</scope><scope>OTOTI</scope></search><sort><creationdate>1990</creationdate><title>Sensitivity of the sodium efflux in single barnacle muscle fibers to the microinjection of aluminum</title><author>Bittar, E.Edward ; Nwoga, Jude ; Huang, Yong-Ping</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c444t-e8aae4b38ede10629682d0926caac227f6c7e89a0810cf9c9365eeee12a5166b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>560300 - Chemicals Metabolism & Toxicology</topic><topic>ALKALI METALS</topic><topic>ALUMINIUM</topic><topic>Aluminum - administration & dosage</topic><topic>Aluminum - pharmacology</topic><topic>Aluminum Chloride</topic><topic>Aluminum Compounds</topic><topic>ANIMALS</topic><topic>AQUATIC ORGANISMS</topic><topic>ARTHROPODS</topic><topic>Balanus nubilus</topic><topic>Biological and medical sciences</topic><topic>BIOLOGICAL EFFECTS</topic><topic>BIOSYNTHESIS</topic><topic>Chemical and industrial products toxicology. Toxic occupational diseases</topic><topic>Chlorides - administration & dosage</topic><topic>Chlorides - pharmacology</topic><topic>CRUSTACEANS</topic><topic>Dose-Response Relationship, Drug</topic><topic>DOSE-RESPONSE RELATIONSHIPS</topic><topic>Drug Interactions</topic><topic>ELEMENTS</topic><topic>IN VITRO</topic><topic>In Vitro Techniques</topic><topic>INVERTEBRATES</topic><topic>Marine</topic><topic>Medical sciences</topic><topic>METALS</topic><topic>Metals and various inorganic compounds</topic><topic>Microinjections</topic><topic>MUSCLES</topic><topic>Muscles - drug effects</topic><topic>Muscles - metabolism</topic><topic>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</topic><topic>SODIUM</topic><topic>Sodium - metabolism</topic><topic>Sodium Channels - drug effects</topic><topic>Sodium Channels - metabolism</topic><topic>Sodium Radioisotopes</topic><topic>SYNTHESIS</topic><topic>Thoracica - drug effects</topic><topic>Thoracica - metabolism</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bittar, E.Edward</creatorcontrib><creatorcontrib>Nwoga, Jude</creatorcontrib><creatorcontrib>Huang, Yong-Ping</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Pollution Abstracts</collection><collection>Safety Science and Risk</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>OSTI.GOV</collection><jtitle>Toxicology and applied pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bittar, E.Edward</au><au>Nwoga, Jude</au><au>Huang, Yong-Ping</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sensitivity of the sodium efflux in single barnacle muscle fibers to the microinjection of aluminum</atitle><jtitle>Toxicology and applied pharmacology</jtitle><addtitle>Toxicol Appl Pharmacol</addtitle><date>1990</date><risdate>1990</risdate><volume>102</volume><issue>1</issue><spage>174</spage><epage>185</epage><pages>174-185</pages><issn>0041-008X</issn><eissn>1096-0333</eissn><coden>TXAPA9</coden><abstract>A study has been made of the behavior of the Na efflux in single muscle fibers from the barnacle,
Balanus nubilus, toward the microinjection of AlCl
3. The effect of microinjecting AlCl
3 is either biphasic with inhibition following transitory stimulation, or monophasic with inhibition occurring promptly and taking about 1 hr to reach a maximum. The magnitude of the inhibition is dose dependent and the minimally effective concentration is 10 m
m. This is diluted by the myoplasm by a factor of roughly 100. Fibers injected with 1
m AlCl
3 are found to be insensitive to 10
−4
m ouabain, whereas fibers injected with 0.5
m AlCl
3 show a further fall in Na efflux, which is smaller than that seen in control fibers. The response of the ouabain-insensitive Na efflux to the injection of 0.5
m AlCl
3 is biphasic: stimulation is followed by inhibition. The stimulatory phase is largely dependent on the presence of external Ca
2+ and is reversed by the sudden omission of Ca
2+ from the bathing medium. Fibers also injected with 0.5
m AlCl
3 show a marked reduction in the response of the Na efflux to high external K. Injection of ATPMg before or after the injection of AlCl
3 fails in most instances to abolish or reverse the inhibitory effect. By contrast, fibers preinjected with deferoxamine show little or no effect following the injection of AlCl
3. However, external application of deferoxamine is ineffective.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>2153318</pmid><doi>10.1016/0041-008X(90)90094-B</doi><tpages>12</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0041-008X |
| ispartof | Toxicology and applied pharmacology, 1990, Vol.102 (1), p.174-185 |
| issn | 0041-008X 1096-0333 |
| language | eng |
| recordid | cdi_osti_scitechconnect_7167276 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | 560300 - Chemicals Metabolism & Toxicology ALKALI METALS ALUMINIUM Aluminum - administration & dosage Aluminum - pharmacology Aluminum Chloride Aluminum Compounds ANIMALS AQUATIC ORGANISMS ARTHROPODS Balanus nubilus Biological and medical sciences BIOLOGICAL EFFECTS BIOSYNTHESIS Chemical and industrial products toxicology. Toxic occupational diseases Chlorides - administration & dosage Chlorides - pharmacology CRUSTACEANS Dose-Response Relationship, Drug DOSE-RESPONSE RELATIONSHIPS Drug Interactions ELEMENTS IN VITRO In Vitro Techniques INVERTEBRATES Marine Medical sciences METALS Metals and various inorganic compounds Microinjections MUSCLES Muscles - drug effects Muscles - metabolism RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT SODIUM Sodium - metabolism Sodium Channels - drug effects Sodium Channels - metabolism Sodium Radioisotopes SYNTHESIS Thoracica - drug effects Thoracica - metabolism Toxicology |
| title | Sensitivity of the sodium efflux in single barnacle muscle fibers to the microinjection of aluminum |
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