A majority of Ig H chain cDNA of normal human adult blood lymphocytes resembles cDNA for fetal Ig and natural autoantibodies

Certain Ig VH gene segments, with few or no mutations, recur frequently in natural autoantibodies, fetal antibodies, and products of B cell tumors. The goal of this study was to determine whether similar Ig gene segment usage occurs in normal human adult PBL. Extending previous analyses, 105 randoml...

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Veröffentlicht in:	The Journal of immunology (1950) 1993-11, Vol.151 (10), p.5290-5300
Hauptverfasser:	Huang, C, Stollar, BD
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult ANIMAL CELLS Autoantibodies - genetics Base Sequence BASIC BIOLOGICAL SCIENCES Biological and medical sciences BIOLOGICAL MATERIALS BLOOD BLOOD CELLS BODY FLUIDS CONNECTIVE TISSUE CELLS DISEASES DNA SEQUENCING DNA, Complementary - analysis DNA, Complementary - chemistry Female Fetus - immunology Fundamental and applied biological sciences. Psychology GENES Genes, Immunoglobulin Genes. Genome GLOBULINS Humans Immunoglobulin G - genetics Immunoglobulin Heavy Chains - genetics Immunoglobulin M - genetics Immunoglobulin Variable Region - genetics IMMUNOGLOBULINS LEUKOCYTES LYMPHOCYTES Lymphocytes - immunology MATERIALS Molecular and cellular biology Molecular genetics Molecular Sequence Data Mutation NEOPLASMS ORGANIC COMPOUNDS Pregnancy PROTEINS SOMATIC CELLS STRUCTURAL CHEMICAL ANALYSIS 550400 > Genetics
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