CTLA-4 and CD28 mRNA are coexpressed in most T cells after activation. Expression of CTLA-4 and CD28 mRNA does not correlate with the pattern of lymphokine production

Ag-presenting cells provide at least two distinct signals for T cell activation. T cell receptor-dependent stimulation is provided by presentation of a specific peptide Ag in association with MHC molecules. In addition, APC also supply costimulatory signals required for T cell activation that are ne...

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Veröffentlicht in:	The Journal of immunology (1950) 1992-12, Vol.149 (12), p.3795-3801
Hauptverfasser:	Freeman, GJ, Lombard, DB, Gimmi, CD, Brod, SA, Lee, K, Laning, JC, Hafler, DA, Dorf, ME, Gray, GS, Reiser, H
Format:	Artikel
Sprache:	eng
Schlagworte:	550200 > Biochemistry Abatacept AIDS/HIV ANIMAL CELLS Animals ANTIGENS Antigens, CD - biosynthesis Antigens, Differentiation - biosynthesis Antigens, Differentiation, T-Lymphocyte - biosynthesis Antigens, Surface - biosynthesis B7-1 Antigen Base Sequence BASIC BIOLOGICAL SCIENCES Biological and medical sciences BIOLOGICAL MATERIALS BIOLOGY BLOOD BLOOD CELLS Blotting, Northern BODY FLUIDS CD28 Antigens Cell Adhesion Molecules - biosynthesis Cell Line CONNECTIVE TISSUE CELLS CTLA-4 Antigen DATA EXPERIMENTAL DATA Fundamental and applied biological sciences. Psychology Fundamental immunology GENE REGULATION GENES GENETICS GROWTH FACTORS HISTOCOMPATIBILITY COMPLEX Humans Immunobiology Immunoconjugates INFORMATION Interferon-gamma - biosynthesis Interleukins - biosynthesis Leukemia, T-Cell - immunology LEUKOCYTES Lymphocyte Activation - immunology LYMPHOCYTES Lymphoid cells: ontogeny, maturation, markers, receptors, circulation and recirculation LYMPHOKINES Lymphokines - biosynthesis MATERIALS MEMBRANE PROTEINS Mice MITOGENS Molecular Sequence Data NUMERICAL DATA Oligonucleotide Probes ORGANIC COMPOUNDS Polymerase Chain Reaction PRODUCTION PROTEINS RECEPTORS RNA, Messenger - biosynthesis SOMATIC CELLS 550400 > Genetics T-Lymphocytes - metabolism THYMUS CELLS Tumor Necrosis Factor-alpha - biosynthesis
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