Unwinding and hydrodynamic flow linear dichroism characteristics of supercoiled DNA covalently modified with two isomeric methylchrysene diol epoxides of different biological activities

Adducts derived from the covalent binding of two positional monomethyl-substituted isomers of a bay region chrysene diol epoxide to supercoiled pIBI30 DNA (2926 base pairs/genome) were prepared, and their characteristics were investigated by a combination of gel electrophoresis and flow linear dichr...

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Veröffentlicht in:	Chemical research in toxicology 1993-09, Vol.6 (5), p.616-624
Hauptverfasser:	Balasta, Luisa, Xu, Rong, Geacintov, Nicholas E, Swenberg, Charles E, Amin, Shantu, Hecht, Stephen S
Format:	Artikel
Sprache:	eng
Schlagworte:	550200 - Biochemistry 560300 - Chemicals Metabolism & Toxicology ADDUCTS AROMATICS BASIC BIOLOGICAL SCIENCES Biological and medical sciences BIOSYNTHESIS Chemical mutagenesis Chemical Phenomena Chemistry, Physical CHRYSENE Chrysenes - chemistry CONDENSED AROMATICS CONFIGURATION DICHROISM DNA DNA ADDUCTS DNA, Bacterial - chemistry DNA, Superhelical - chemistry ELECTROPHORESIS Electrophoresis, Agar Gel Electrophoresis, Polyacrylamide Gel Escherichia coli - metabolism HYDROCARBONS Medical sciences MUTAGENESIS Nickel - chemistry Nucleic Acid Conformation NUCLEIC ACIDS ORGANIC COMPOUNDS Plasmids RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT Stereoisomerism STRUCTURAL CHEMICAL ANALYSIS SYNTHESIS Toxicology
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