Osteotoxicity after chronic dietary administration of 13-cis-retinoic acid, retinyl palmitate or selenium in mice exposed to tumor initiation and promotion

In view of the clinical trials of retinoids as therapeutic agents for premalignant skin lesions, a radiographic study was undertaken to measure skeletal toxicities after chronic dietary administration of retinoids in mice exposed to tumor initiation and promotion. CD-1 mice were initiated with 0.15...

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Veröffentlicht in:	Life sciences (1973) 1989, Vol.45 (22), p.2149-2156
Hauptverfasser:	Forsyth, K.S., Watson, R.R., Gensler, H.L.
Format:	Artikel
Sprache:	eng
Schlagworte:	550602 - Medicine- External Radiation in Diagnostics- (1980-) 560300 - Chemicals Metabolism & Toxicology Administration, Oral ANIMALS AROMATICS BENZANTHRACENE Biological and medical sciences BIOLOGICAL EFFECTS BIOMEDICAL RADIOGRAPHY Bone and Bones - drug effects Bone Diseases - chemically induced CARBOXYLIC ACID ESTERS CARCINOGENESIS CARCINOGENS Carcinogens - pharmacology CHRONIC EXPOSURE CONDENSED AROMATICS DIAGNOSIS DIAGNOSTIC TECHNIQUES DIET DISEASES Dose-Response Relationship, Drug Drug toxicity and drugs side effects treatment ELEMENTS ESTERS Female HYDROCARBONS MAMMALS Medical sciences MEDICINE MICE Mice, Inbred Strains Miscellaneous (drug allergy, mutagens, teratogens...) NUCLEAR MEDICINE ORGANIC COMPOUNDS Osteoporosis - chemically induced PATHOGENESIS Pharmacology. Drug treatments PHORBOL ESTERS RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RADIOLOGY RADIOLOGY AND NUCLEAR MEDICINE RETINOIC ACID RODENTS SELENIUM Selenium - administration & dosage Selenium - adverse effects Selenium - therapeutic use SEMIMETALS SKELETAL DISEASES Skin Neoplasms - chemically induced Skin Neoplasms - drug therapy TOXICITY Tretinoin - administration & dosage Tretinoin - adverse effects Tretinoin - therapeutic use VERTEBRATES Vitamin A - administration & dosage Vitamin A - adverse effects Vitamin A - analogs & derivatives Vitamin A - therapeutic use
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