Cadmium inhibition of l-alanine transport into renal brush border membrane vesicles isolated from the winter flounder ( Pseudopleuronectes americanus)

Using isolated brush border membrane vesicles from the kidney of the winter flounder ( Pseudopleuronectes americanus), we have studied the effect of cadmium on l-alanine transport. Pretreatment of vesicles with 0.1 m m Cd 2+ resulted in inhibition of l-alanine uptake in the presence of a NaCl (but n...

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Veröffentlicht in:	Toxicology and applied pharmacology 1989-12, Vol.101 (3), p.461-469
Hauptverfasser:	Bevan, C., Kinne-Saffran, E., Foulkes, E.C., Kinne, R.K.H.
Format:	Artikel
Sprache:	eng
Schlagworte:	560300 - Chemicals Metabolism & Toxicology Alanine - metabolism Alanine - pharmacokinetics ALANINES ALKALI METALS Amino Acid Transport Systems Amino Acid Transport Systems, Neutral AMINO ACIDS ANIMALS AQUATIC ORGANISMS Biological and medical sciences Biological Transport - drug effects BODY CADMIUM Cadmium - toxicity CARBOXYLIC ACIDS Carrier Proteins - antagonists & inhibitors CELL CONSTITUENTS CELL MEMBRANES CYTOPLASM Cytoplasm - metabolism ELEMENTS Environmental pollutants toxicology Female FISHES Flounder - metabolism General aspects INHIBITION Kidney - drug effects Kidney - metabolism KIDNEYS Male Marine Medical sciences MEMBRANE TRANSPORT MEMBRANES METALS Microvilli - metabolism ORGANIC ACIDS ORGANIC COMPOUNDS ORGANS POLLUTION PROTEINS Pseudopleuronectes americanus RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT SODIUM Sodium - metabolism Symporters TIME DEPENDENCE TOXICITY Toxicology VERTEBRATES Water Pollutants - toxicity Water Pollutants, Chemical - toxicity WATER POLLUTION
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