Organization of the Human Lipoprotein Lipase Gene and Evolution of the Lipase Gene Family

The human lipoprotein lipase gene was cloned and characterized. It is composed of 10 exons spanning ≈ 30 kilobases. The first exon encodes the 5′-untranslated region, the signal peptide plus the first two amino acids of the mature protein. The next eight exons encode the remaining 446 amino acids, a...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1989-12, Vol.86 (24), p.9647-9651
Hauptverfasser:	Kirchgessner, Todd G., Chuat, Jean-Claude, Heinzmann, Camilla, Etienne, Jacqueline, Guilhot, Stephane, Svenson, Karen, Ameis, Detlev, Pilon, Catherine, d'Auriol, Luc, Andalibi, Ali, Schotz, Michael C., Galibert, Francis, Lusis, Aldons J.
Format:	Artikel
Sprache:	eng
Schlagworte:	550200 - Biochemistry AMINO ACID SEQUENCE Amino acids ANIMALS ARTHROPODS Base Sequence BASIC BIOLOGICAL SCIENCES Biological and medical sciences BIOLOGICAL EVOLUTION BODY CARBOXYLESTERASES DIGESTIVE SYSTEM DIPTERA DOGS DROSOPHILA Egg proteins ENDOCRINE GLANDS ENZYMES ESTERASES Evolution evolutionary genetics Exons FLIES FRUIT FLIES Fundamental and applied biological sciences. Psychology Gene Library GENES Genes. Genome GLANDS Humans HYDROLASES INSECTS Introns INVERTEBRATES Lipase - genetics LIPASES LIPIDS Lipoprotein Lipase - genetics LIPOPROTEINS LIVER MAMMALS MAN MESSENGER-RNA Molecular and cellular biology Molecular genetics Molecular Sequence Data MOLECULAR STRUCTURE Multigene Family NUCLEIC ACIDS NUCLEOTIDES ORGANIC COMPOUNDS ORGANS PANCREAS PRIMATES PROTEINS Restriction Mapping RNA Sequence Homology, Nucleic Acid Sulfation TRANSCRIPTION Transcription, Genetic VERTEBRATES
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