Organization of the Human Lipoprotein Lipase Gene and Evolution of the Lipase Gene Family
The human lipoprotein lipase gene was cloned and characterized. It is composed of 10 exons spanning ≈ 30 kilobases. The first exon encodes the 5′-untranslated region, the signal peptide plus the first two amino acids of the mature protein. The next eight exons encode the remaining 446 amino acids, a...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 1989-12, Vol.86 (24), p.9647-9651 |
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| creator | Kirchgessner, Todd G. Chuat, Jean-Claude Heinzmann, Camilla Etienne, Jacqueline Guilhot, Stephane Svenson, Karen Ameis, Detlev Pilon, Catherine d'Auriol, Luc Andalibi, Ali Schotz, Michael C. Galibert, Francis Lusis, Aldons J. |
| description | The human lipoprotein lipase gene was cloned and characterized. It is composed of 10 exons spanning ≈ 30 kilobases. The first exon encodes the 5′-untranslated region, the signal peptide plus the first two amino acids of the mature protein. The next eight exons encode the remaining 446 amino acids, and the tenth exon encodes the long 3′-untranslated region of 1948 nucleotides. The lipoprotein lipase transcription start site and the sequence of the 5′-flanking region were also determined. We compared the organization of genes for lipoprotein lipase, hepatic lipase, pancreatic lipase, and Drosophila yolk protein 1, which are members of a family of related genes. A model for the evolution of the lipase gene family is presented that involves multiple rounds of gene duplication plus exon-shuffling and intron-loss events. |
| doi_str_mv | 10.1073/pnas.86.24.9647 |
| format | Article |
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It is composed of 10 exons spanning ≈ 30 kilobases. The first exon encodes the 5′-untranslated region, the signal peptide plus the first two amino acids of the mature protein. The next eight exons encode the remaining 446 amino acids, and the tenth exon encodes the long 3′-untranslated region of 1948 nucleotides. The lipoprotein lipase transcription start site and the sequence of the 5′-flanking region were also determined. We compared the organization of genes for lipoprotein lipase, hepatic lipase, pancreatic lipase, and Drosophila yolk protein 1, which are members of a family of related genes. A model for the evolution of the lipase gene family is presented that involves multiple rounds of gene duplication plus exon-shuffling and intron-loss events.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.86.24.9647</identifier><identifier>PMID: 2602366</identifier><identifier>CODEN: PNASA6</identifier><language>eng</language><publisher>Washington, DC: National Academy of Sciences of the United States of America</publisher><subject>550200 - Biochemistry ; AMINO ACID SEQUENCE ; Amino acids ; ANIMALS ; ARTHROPODS ; Base Sequence ; BASIC BIOLOGICAL SCIENCES ; Biological and medical sciences ; BIOLOGICAL EVOLUTION ; BODY ; CARBOXYLESTERASES ; DIGESTIVE SYSTEM ; DIPTERA ; DOGS ; DROSOPHILA ; Egg proteins ; ENDOCRINE GLANDS ; ENZYMES ; ESTERASES ; Evolution ; evolutionary genetics ; Exons ; FLIES ; FRUIT FLIES ; Fundamental and applied biological sciences. Psychology ; Gene Library ; GENES ; Genes. Genome ; GLANDS ; Humans ; HYDROLASES ; INSECTS ; Introns ; INVERTEBRATES ; Lipase - genetics ; LIPASES ; LIPIDS ; Lipoprotein Lipase - genetics ; LIPOPROTEINS ; LIVER ; MAMMALS ; MAN ; MESSENGER-RNA ; Molecular and cellular biology ; Molecular genetics ; Molecular Sequence Data ; MOLECULAR STRUCTURE ; Multigene Family ; NUCLEIC ACIDS ; NUCLEOTIDES ; ORGANIC COMPOUNDS ; ORGANS ; PANCREAS ; PRIMATES ; PROTEINS ; Restriction Mapping ; RNA ; Sequence Homology, Nucleic Acid ; Sulfation ; TRANSCRIPTION ; Transcription, Genetic ; VERTEBRATES</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 1989-12, Vol.86 (24), p.9647-9651</ispartof><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c583t-b0b75acfea455895dfa5a5be2f467b57c120935c2c003a874e3cd8553bbdf4263</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/86/24.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/34712$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/34712$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,723,776,780,799,881,27901,27902,53766,53768,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6873117$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2602366$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/6970617$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Kirchgessner, Todd G.</creatorcontrib><creatorcontrib>Chuat, Jean-Claude</creatorcontrib><creatorcontrib>Heinzmann, Camilla</creatorcontrib><creatorcontrib>Etienne, Jacqueline</creatorcontrib><creatorcontrib>Guilhot, Stephane</creatorcontrib><creatorcontrib>Svenson, Karen</creatorcontrib><creatorcontrib>Ameis, Detlev</creatorcontrib><creatorcontrib>Pilon, Catherine</creatorcontrib><creatorcontrib>d'Auriol, Luc</creatorcontrib><creatorcontrib>Andalibi, Ali</creatorcontrib><creatorcontrib>Schotz, Michael C.</creatorcontrib><creatorcontrib>Galibert, Francis</creatorcontrib><creatorcontrib>Lusis, Aldons J.</creatorcontrib><title>Organization of the Human Lipoprotein Lipase Gene and Evolution of the Lipase Gene Family</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>The human lipoprotein lipase gene was cloned and characterized. It is composed of 10 exons spanning ≈ 30 kilobases. The first exon encodes the 5′-untranslated region, the signal peptide plus the first two amino acids of the mature protein. The next eight exons encode the remaining 446 amino acids, and the tenth exon encodes the long 3′-untranslated region of 1948 nucleotides. The lipoprotein lipase transcription start site and the sequence of the 5′-flanking region were also determined. We compared the organization of genes for lipoprotein lipase, hepatic lipase, pancreatic lipase, and Drosophila yolk protein 1, which are members of a family of related genes. A model for the evolution of the lipase gene family is presented that involves multiple rounds of gene duplication plus exon-shuffling and intron-loss events.</description><subject>550200 - Biochemistry</subject><subject>AMINO ACID SEQUENCE</subject><subject>Amino acids</subject><subject>ANIMALS</subject><subject>ARTHROPODS</subject><subject>Base Sequence</subject><subject>BASIC BIOLOGICAL SCIENCES</subject><subject>Biological and medical sciences</subject><subject>BIOLOGICAL EVOLUTION</subject><subject>BODY</subject><subject>CARBOXYLESTERASES</subject><subject>DIGESTIVE SYSTEM</subject><subject>DIPTERA</subject><subject>DOGS</subject><subject>DROSOPHILA</subject><subject>Egg proteins</subject><subject>ENDOCRINE GLANDS</subject><subject>ENZYMES</subject><subject>ESTERASES</subject><subject>Evolution</subject><subject>evolutionary genetics</subject><subject>Exons</subject><subject>FLIES</subject><subject>FRUIT FLIES</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Library</subject><subject>GENES</subject><subject>Genes. Genome</subject><subject>GLANDS</subject><subject>Humans</subject><subject>HYDROLASES</subject><subject>INSECTS</subject><subject>Introns</subject><subject>INVERTEBRATES</subject><subject>Lipase - genetics</subject><subject>LIPASES</subject><subject>LIPIDS</subject><subject>Lipoprotein Lipase - genetics</subject><subject>LIPOPROTEINS</subject><subject>LIVER</subject><subject>MAMMALS</subject><subject>MAN</subject><subject>MESSENGER-RNA</subject><subject>Molecular and cellular biology</subject><subject>Molecular genetics</subject><subject>Molecular Sequence Data</subject><subject>MOLECULAR STRUCTURE</subject><subject>Multigene Family</subject><subject>NUCLEIC ACIDS</subject><subject>NUCLEOTIDES</subject><subject>ORGANIC COMPOUNDS</subject><subject>ORGANS</subject><subject>PANCREAS</subject><subject>PRIMATES</subject><subject>PROTEINS</subject><subject>Restriction Mapping</subject><subject>RNA</subject><subject>Sequence Homology, Nucleic Acid</subject><subject>Sulfation</subject><subject>TRANSCRIPTION</subject><subject>Transcription, Genetic</subject><subject>VERTEBRATES</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc9rFDEcxYModa2eBUEZiuhptpn8noOHUvpDWOhFD57CdzKZbspMsiaZ0vrXO9sdl-3FUwLv8973wUPofYWXFZb0dOMhLZVYErasBZMv0KLCdVUKVuOXaIExkaVihL1Gb1K6wxjXXOEjdEQEJlSIBfp1E2_Buz-QXfBF6Iq8tsX1OIAvVm4TNjFk657-kGxxZb0twLfFxX3ox0PLIXAJg-sf36JXHfTJvpvfY_Tz8uLH-XW5urn6fn62Kg1XNJcNbiQH01lgnKuatx1w4I0lHROy4dJUBNeUG2IwpqAks9S0inPaNG3HiKDH6NsudzM2g22N9TlCrzfRDRAfdQCnnyverfVtuNeknmLU5D_Z-UPKTifjsjVrE7y3JmtRSywqOUFf5iMx_B5tynpwydi-B2_DmHTFqRJYsgk83YEmhpSi7fZFKqy3i-ntYloJTZjeLjY5Ph723_PzRJP-edYhGei7CN64tMeEkrR6avhpxrb5_9Rnd77-F9Dd2PfZPuSJ_LAj71IOcY9SJitC_wKC5cCP</recordid><startdate>19891201</startdate><enddate>19891201</enddate><creator>Kirchgessner, Todd G.</creator><creator>Chuat, Jean-Claude</creator><creator>Heinzmann, Camilla</creator><creator>Etienne, Jacqueline</creator><creator>Guilhot, Stephane</creator><creator>Svenson, Karen</creator><creator>Ameis, Detlev</creator><creator>Pilon, Catherine</creator><creator>d'Auriol, Luc</creator><creator>Andalibi, Ali</creator><creator>Schotz, Michael C.</creator><creator>Galibert, Francis</creator><creator>Lusis, Aldons J.</creator><general>National Academy of Sciences of the United States of America</general><general>National Acad Sciences</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T3</scope><scope>7TM</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>M81</scope><scope>P64</scope><scope>RC3</scope><scope>OTOTI</scope><scope>5PM</scope></search><sort><creationdate>19891201</creationdate><title>Organization of the Human Lipoprotein Lipase Gene and Evolution of the Lipase Gene Family</title><author>Kirchgessner, Todd G. ; Chuat, Jean-Claude ; Heinzmann, Camilla ; Etienne, Jacqueline ; Guilhot, Stephane ; Svenson, Karen ; Ameis, Detlev ; Pilon, Catherine ; d'Auriol, Luc ; Andalibi, Ali ; Schotz, Michael C. ; Galibert, Francis ; Lusis, Aldons J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c583t-b0b75acfea455895dfa5a5be2f467b57c120935c2c003a874e3cd8553bbdf4263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>550200 - Biochemistry</topic><topic>AMINO ACID SEQUENCE</topic><topic>Amino acids</topic><topic>ANIMALS</topic><topic>ARTHROPODS</topic><topic>Base Sequence</topic><topic>BASIC BIOLOGICAL SCIENCES</topic><topic>Biological and medical sciences</topic><topic>BIOLOGICAL EVOLUTION</topic><topic>BODY</topic><topic>CARBOXYLESTERASES</topic><topic>DIGESTIVE SYSTEM</topic><topic>DIPTERA</topic><topic>DOGS</topic><topic>DROSOPHILA</topic><topic>Egg proteins</topic><topic>ENDOCRINE GLANDS</topic><topic>ENZYMES</topic><topic>ESTERASES</topic><topic>Evolution</topic><topic>evolutionary genetics</topic><topic>Exons</topic><topic>FLIES</topic><topic>FRUIT FLIES</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Library</topic><topic>GENES</topic><topic>Genes. Genome</topic><topic>GLANDS</topic><topic>Humans</topic><topic>HYDROLASES</topic><topic>INSECTS</topic><topic>Introns</topic><topic>INVERTEBRATES</topic><topic>Lipase - genetics</topic><topic>LIPASES</topic><topic>LIPIDS</topic><topic>Lipoprotein Lipase - genetics</topic><topic>LIPOPROTEINS</topic><topic>LIVER</topic><topic>MAMMALS</topic><topic>MAN</topic><topic>MESSENGER-RNA</topic><topic>Molecular and cellular biology</topic><topic>Molecular genetics</topic><topic>Molecular Sequence Data</topic><topic>MOLECULAR STRUCTURE</topic><topic>Multigene Family</topic><topic>NUCLEIC ACIDS</topic><topic>NUCLEOTIDES</topic><topic>ORGANIC COMPOUNDS</topic><topic>ORGANS</topic><topic>PANCREAS</topic><topic>PRIMATES</topic><topic>PROTEINS</topic><topic>Restriction Mapping</topic><topic>RNA</topic><topic>Sequence Homology, Nucleic Acid</topic><topic>Sulfation</topic><topic>TRANSCRIPTION</topic><topic>Transcription, Genetic</topic><topic>VERTEBRATES</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kirchgessner, Todd G.</creatorcontrib><creatorcontrib>Chuat, Jean-Claude</creatorcontrib><creatorcontrib>Heinzmann, Camilla</creatorcontrib><creatorcontrib>Etienne, Jacqueline</creatorcontrib><creatorcontrib>Guilhot, Stephane</creatorcontrib><creatorcontrib>Svenson, Karen</creatorcontrib><creatorcontrib>Ameis, Detlev</creatorcontrib><creatorcontrib>Pilon, Catherine</creatorcontrib><creatorcontrib>d'Auriol, Luc</creatorcontrib><creatorcontrib>Andalibi, Ali</creatorcontrib><creatorcontrib>Schotz, Michael C.</creatorcontrib><creatorcontrib>Galibert, Francis</creatorcontrib><creatorcontrib>Lusis, Aldons J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Human Genome Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biochemistry Abstracts 3</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>OSTI.GOV</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kirchgessner, Todd G.</au><au>Chuat, Jean-Claude</au><au>Heinzmann, Camilla</au><au>Etienne, Jacqueline</au><au>Guilhot, Stephane</au><au>Svenson, Karen</au><au>Ameis, Detlev</au><au>Pilon, Catherine</au><au>d'Auriol, Luc</au><au>Andalibi, Ali</au><au>Schotz, Michael C.</au><au>Galibert, Francis</au><au>Lusis, Aldons J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Organization of the Human Lipoprotein Lipase Gene and Evolution of the Lipase Gene Family</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>1989-12-01</date><risdate>1989</risdate><volume>86</volume><issue>24</issue><spage>9647</spage><epage>9651</epage><pages>9647-9651</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><coden>PNASA6</coden><abstract>The human lipoprotein lipase gene was cloned and characterized. It is composed of 10 exons spanning ≈ 30 kilobases. The first exon encodes the 5′-untranslated region, the signal peptide plus the first two amino acids of the mature protein. The next eight exons encode the remaining 446 amino acids, and the tenth exon encodes the long 3′-untranslated region of 1948 nucleotides. The lipoprotein lipase transcription start site and the sequence of the 5′-flanking region were also determined. We compared the organization of genes for lipoprotein lipase, hepatic lipase, pancreatic lipase, and Drosophila yolk protein 1, which are members of a family of related genes. A model for the evolution of the lipase gene family is presented that involves multiple rounds of gene duplication plus exon-shuffling and intron-loss events.</abstract><cop>Washington, DC</cop><pub>National Academy of Sciences of the United States of America</pub><pmid>2602366</pmid><doi>10.1073/pnas.86.24.9647</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0027-8424 |
| ispartof | Proceedings of the National Academy of Sciences - PNAS, 1989-12, Vol.86 (24), p.9647-9651 |
| issn | 0027-8424 1091-6490 |
| language | eng |
| recordid | cdi_osti_scitechconnect_6970617 |
| source | Jstor Complete Legacy; MEDLINE; PubMed; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | 550200 - Biochemistry AMINO ACID SEQUENCE Amino acids ANIMALS ARTHROPODS Base Sequence BASIC BIOLOGICAL SCIENCES Biological and medical sciences BIOLOGICAL EVOLUTION BODY CARBOXYLESTERASES DIGESTIVE SYSTEM DIPTERA DOGS DROSOPHILA Egg proteins ENDOCRINE GLANDS ENZYMES ESTERASES Evolution evolutionary genetics Exons FLIES FRUIT FLIES Fundamental and applied biological sciences. Psychology Gene Library GENES Genes. Genome GLANDS Humans HYDROLASES INSECTS Introns INVERTEBRATES Lipase - genetics LIPASES LIPIDS Lipoprotein Lipase - genetics LIPOPROTEINS LIVER MAMMALS MAN MESSENGER-RNA Molecular and cellular biology Molecular genetics Molecular Sequence Data MOLECULAR STRUCTURE Multigene Family NUCLEIC ACIDS NUCLEOTIDES ORGANIC COMPOUNDS ORGANS PANCREAS PRIMATES PROTEINS Restriction Mapping RNA Sequence Homology, Nucleic Acid Sulfation TRANSCRIPTION Transcription, Genetic VERTEBRATES |
| title | Organization of the Human Lipoprotein Lipase Gene and Evolution of the Lipase Gene Family |
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