Assessment of exposure to carbon disulfide in viscose production workers from urinary 2-thiothiazolidine-4-carboxylic acid determinations
The follow‐up of environmental carbon disulfide (CS2) exposure and urinary excretion of 2‐thiothiazolidine‐4‐carboxylic acid (TTCA) among 20 operatives over a 4‐day working week in two viscose producing factories confirmed earlier observations that TTCA is a sensitive and reliable indicator of expos...
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| Veröffentlicht in: | American journal of industrial medicine 1992, Vol.22 (1), p.85-97 |
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| creator | Riihimäki, V. Kivistö, H. Peltonen, K. Helpiö, E. Aitio, A. |
| description | The follow‐up of environmental carbon disulfide (CS2) exposure and urinary excretion of 2‐thiothiazolidine‐4‐carboxylic acid (TTCA) among 20 operatives over a 4‐day working week in two viscose producing factories confirmed earlier observations that TTCA is a sensitive and reliable indicator of exposure to CS2. Exposure to as low as 0.5–1.0 ppm (1.6–3.2 mg/m3) of CS2 (8‐hour time‐weighted average [TWA]) was associated with detectable amounts of TTCA in end‐of‐shift urine. Moreover, the excretion of TTCA, relative to estimated CS2 uptake, appeared surprisingly constant in the studied work force. Approximately 3% (range 2–6.5%) of absorbed CS2 was detected in urine as TTCA. The proportional TTCA excretion did not show dose dependency in the estimated CS2 dose range which varied by about 20‐fold. TTCA elimination exhibited both a fast (T 1/2 6 hour) and a slow (T 1/2 68 hour) phase. The slow elimination is compatible with a high lipid solubility and reversible protein binding of CS2. Consequently, urinary excretion of TTCA, relative to CS2 exposure, increased by about a third during the workweek. Urinary TTCA concentration of 4.5 mmol/mol creatinine in a postshift sample corresponded to a TWA exposure to 10 ppm CS2 towards the end of the working week. © 1992 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/ajim.4700220108 |
| format | Article |
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Exposure to as low as 0.5–1.0 ppm (1.6–3.2 mg/m3) of CS2 (8‐hour time‐weighted average [TWA]) was associated with detectable amounts of TTCA in end‐of‐shift urine. Moreover, the excretion of TTCA, relative to estimated CS2 uptake, appeared surprisingly constant in the studied work force. Approximately 3% (range 2–6.5%) of absorbed CS2 was detected in urine as TTCA. The proportional TTCA excretion did not show dose dependency in the estimated CS2 dose range which varied by about 20‐fold. TTCA elimination exhibited both a fast (T 1/2 6 hour) and a slow (T 1/2 68 hour) phase. The slow elimination is compatible with a high lipid solubility and reversible protein binding of CS2. Consequently, urinary excretion of TTCA, relative to CS2 exposure, increased by about a third during the workweek. Urinary TTCA concentration of 4.5 mmol/mol creatinine in a postshift sample corresponded to a TWA exposure to 10 ppm CS2 towards the end of the working week. © 1992 Wiley‐Liss, Inc.</description><identifier>ISSN: 0271-3586</identifier><identifier>EISSN: 1097-0274</identifier><identifier>DOI: 10.1002/ajim.4700220108</identifier><identifier>PMID: 1415281</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adult ; Air Pollutants, Occupational - analysis ; ANIMALS ; AZOLES ; BIOLOGICAL MARKERS ; biological monitoring ; CARBON COMPOUNDS ; Carbon Disulfide - adverse effects ; Carbon Disulfide - analysis ; carbon disulfide TTCA ; CARBON SULFIDES ; CARBOXYLIC ACIDS ; CHALCOGENIDES ; CLEARANCE ; Environmental Monitoring ; EXCRETION ; Follow-Up Studies ; HAZARDS ; HEALTH HAZARDS ; HETEROCYCLIC COMPOUNDS ; Humans ; INDUSTRY ; Male ; MAMMALS ; MAN ; METABOLISM ; OCCUPATIONAL EXPOSURE ; Occupational Exposure - adverse effects ; Occupational Exposure - analysis ; ORGANIC ACIDS ; ORGANIC COMPOUNDS ; ORGANIC NITROGEN COMPOUNDS ; ORGANIC SULFUR COMPOUNDS ; PERSONNEL ; PRIMATES ; RADIATION, THERMAL, AND OTHER ENVIRON. 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MAT ; reliable indicator ; Respiratory Protective Devices ; Sensitivity and Specificity ; SULFIDES ; SULFUR COMPOUNDS ; TEXTILE INDUSTRY ; THIAZOLES ; Thiazoles - urine ; Thiazolidines ; VERTEBRATES 560300 -- Chemicals Metabolism & Toxicology ; viscose rayon production</subject><ispartof>American journal of industrial medicine, 1992, Vol.22 (1), p.85-97</ispartof><rights>Copyright © 1992 Wiley Periodicals, Inc., A Wiley Company</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5068-7118e0945c2c6b37f6d7f94056e3fd6350d2df188fc9fe6005f2adff065b430d3</citedby><cites>FETCH-LOGICAL-c5068-7118e0945c2c6b37f6d7f94056e3fd6350d2df188fc9fe6005f2adff065b430d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fajim.4700220108$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fajim.4700220108$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,4010,27900,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1415281$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/6913100$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Riihimäki, V.</creatorcontrib><creatorcontrib>Kivistö, H.</creatorcontrib><creatorcontrib>Peltonen, K.</creatorcontrib><creatorcontrib>Helpiö, E.</creatorcontrib><creatorcontrib>Aitio, A.</creatorcontrib><title>Assessment of exposure to carbon disulfide in viscose production workers from urinary 2-thiothiazolidine-4-carboxylic acid determinations</title><title>American journal of industrial medicine</title><addtitle>Am. J. Ind. Med</addtitle><description>The follow‐up of environmental carbon disulfide (CS2) exposure and urinary excretion of 2‐thiothiazolidine‐4‐carboxylic acid (TTCA) among 20 operatives over a 4‐day working week in two viscose producing factories confirmed earlier observations that TTCA is a sensitive and reliable indicator of exposure to CS2. Exposure to as low as 0.5–1.0 ppm (1.6–3.2 mg/m3) of CS2 (8‐hour time‐weighted average [TWA]) was associated with detectable amounts of TTCA in end‐of‐shift urine. Moreover, the excretion of TTCA, relative to estimated CS2 uptake, appeared surprisingly constant in the studied work force. Approximately 3% (range 2–6.5%) of absorbed CS2 was detected in urine as TTCA. The proportional TTCA excretion did not show dose dependency in the estimated CS2 dose range which varied by about 20‐fold. TTCA elimination exhibited both a fast (T 1/2 6 hour) and a slow (T 1/2 68 hour) phase. The slow elimination is compatible with a high lipid solubility and reversible protein binding of CS2. Consequently, urinary excretion of TTCA, relative to CS2 exposure, increased by about a third during the workweek. Urinary TTCA concentration of 4.5 mmol/mol creatinine in a postshift sample corresponded to a TWA exposure to 10 ppm CS2 towards the end of the working week. © 1992 Wiley‐Liss, Inc.</description><subject>Adult</subject><subject>Air Pollutants, Occupational - analysis</subject><subject>ANIMALS</subject><subject>AZOLES</subject><subject>BIOLOGICAL MARKERS</subject><subject>biological monitoring</subject><subject>CARBON COMPOUNDS</subject><subject>Carbon Disulfide - adverse effects</subject><subject>Carbon Disulfide - analysis</subject><subject>carbon disulfide TTCA</subject><subject>CARBON SULFIDES</subject><subject>CARBOXYLIC ACIDS</subject><subject>CHALCOGENIDES</subject><subject>CLEARANCE</subject><subject>Environmental Monitoring</subject><subject>EXCRETION</subject><subject>Follow-Up Studies</subject><subject>HAZARDS</subject><subject>HEALTH HAZARDS</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>Humans</subject><subject>INDUSTRY</subject><subject>Male</subject><subject>MAMMALS</subject><subject>MAN</subject><subject>METABOLISM</subject><subject>OCCUPATIONAL EXPOSURE</subject><subject>Occupational Exposure - adverse effects</subject><subject>Occupational Exposure - analysis</subject><subject>ORGANIC ACIDS</subject><subject>ORGANIC COMPOUNDS</subject><subject>ORGANIC NITROGEN COMPOUNDS</subject><subject>ORGANIC SULFUR COMPOUNDS</subject><subject>PERSONNEL</subject><subject>PRIMATES</subject><subject>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</subject><subject>reliable indicator</subject><subject>Respiratory Protective Devices</subject><subject>Sensitivity and Specificity</subject><subject>SULFIDES</subject><subject>SULFUR COMPOUNDS</subject><subject>TEXTILE INDUSTRY</subject><subject>THIAZOLES</subject><subject>Thiazoles - urine</subject><subject>Thiazolidines</subject><subject>VERTEBRATES 560300 -- Chemicals Metabolism & Toxicology</subject><subject>viscose rayon production</subject><issn>0271-3586</issn><issn>1097-0274</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtvFDEQhC0ECkvgzAnJ4sBtkvY8PLPitIrIAy0BifC4WbN2W3EyM964PWQ3_yD_Gi8TEXHiYLWlqvqk7mLstYADAZAftleuPyjr9M1BQPOEzQTM6wzyunzKZmmIrKga-Zy9ILoCEKKU5R7bE6Wo8kbM2P2CCIl6HCL3luNm7WkMyKPnug0rP3DjaOysM8jdwH850p6Qr4M3o44u6bc-XGMgboPv-Rjc0IYtz7N46Xx67Z3vnHEDZmX2B7jZdk7zVjvDDUYMfQrsOPSSPbNtR_jqYe6zb8cfLo5Os-Xnk7OjxTLTFcgmq4VoEOZlpXMtV0VtpantvIRKYmGNLCowubGiaayeW5QAlc1bYy3IalUWYIp99nbieopOkXYR9aX2w4A6KjkXRbprMr2bTGnRmxEpqj5tjl3XDuhHUkLmFQA0yXg4GXXwRAGtWgfXpxMoAWrXkNo1pB4bSok3D-hx1aN59E-VJP39pN-6Drf_w6nFx7NP_9CzKe0o4uZvug3XStZFXakf5yfqeHn-_evF6Rf1s_gNEp2wFg</recordid><startdate>1992</startdate><enddate>1992</enddate><creator>Riihimäki, V.</creator><creator>Kivistö, H.</creator><creator>Peltonen, K.</creator><creator>Helpiö, E.</creator><creator>Aitio, A.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T2</scope><scope>7U1</scope><scope>7U2</scope><scope>7U7</scope><scope>C1K</scope><scope>OTOTI</scope></search><sort><creationdate>1992</creationdate><title>Assessment of exposure to carbon disulfide in viscose production workers from urinary 2-thiothiazolidine-4-carboxylic acid determinations</title><author>Riihimäki, V. ; Kivistö, H. ; Peltonen, K. ; Helpiö, E. ; Aitio, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5068-7118e0945c2c6b37f6d7f94056e3fd6350d2df188fc9fe6005f2adff065b430d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Adult</topic><topic>Air Pollutants, Occupational - analysis</topic><topic>ANIMALS</topic><topic>AZOLES</topic><topic>BIOLOGICAL MARKERS</topic><topic>biological monitoring</topic><topic>CARBON COMPOUNDS</topic><topic>Carbon Disulfide - adverse effects</topic><topic>Carbon Disulfide - analysis</topic><topic>carbon disulfide TTCA</topic><topic>CARBON SULFIDES</topic><topic>CARBOXYLIC ACIDS</topic><topic>CHALCOGENIDES</topic><topic>CLEARANCE</topic><topic>Environmental Monitoring</topic><topic>EXCRETION</topic><topic>Follow-Up Studies</topic><topic>HAZARDS</topic><topic>HEALTH HAZARDS</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>Humans</topic><topic>INDUSTRY</topic><topic>Male</topic><topic>MAMMALS</topic><topic>MAN</topic><topic>METABOLISM</topic><topic>OCCUPATIONAL EXPOSURE</topic><topic>Occupational Exposure - adverse effects</topic><topic>Occupational Exposure - analysis</topic><topic>ORGANIC ACIDS</topic><topic>ORGANIC COMPOUNDS</topic><topic>ORGANIC NITROGEN COMPOUNDS</topic><topic>ORGANIC SULFUR COMPOUNDS</topic><topic>PERSONNEL</topic><topic>PRIMATES</topic><topic>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</topic><topic>reliable indicator</topic><topic>Respiratory Protective Devices</topic><topic>Sensitivity and Specificity</topic><topic>SULFIDES</topic><topic>SULFUR COMPOUNDS</topic><topic>TEXTILE INDUSTRY</topic><topic>THIAZOLES</topic><topic>Thiazoles - urine</topic><topic>Thiazolidines</topic><topic>VERTEBRATES 560300 -- Chemicals Metabolism & Toxicology</topic><topic>viscose rayon production</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Riihimäki, V.</creatorcontrib><creatorcontrib>Kivistö, H.</creatorcontrib><creatorcontrib>Peltonen, K.</creatorcontrib><creatorcontrib>Helpiö, E.</creatorcontrib><creatorcontrib>Aitio, A.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>OSTI.GOV</collection><jtitle>American journal of industrial medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Riihimäki, V.</au><au>Kivistö, H.</au><au>Peltonen, K.</au><au>Helpiö, E.</au><au>Aitio, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Assessment of exposure to carbon disulfide in viscose production workers from urinary 2-thiothiazolidine-4-carboxylic acid determinations</atitle><jtitle>American journal of industrial medicine</jtitle><addtitle>Am. J. Ind. Med</addtitle><date>1992</date><risdate>1992</risdate><volume>22</volume><issue>1</issue><spage>85</spage><epage>97</epage><pages>85-97</pages><issn>0271-3586</issn><eissn>1097-0274</eissn><abstract>The follow‐up of environmental carbon disulfide (CS2) exposure and urinary excretion of 2‐thiothiazolidine‐4‐carboxylic acid (TTCA) among 20 operatives over a 4‐day working week in two viscose producing factories confirmed earlier observations that TTCA is a sensitive and reliable indicator of exposure to CS2. Exposure to as low as 0.5–1.0 ppm (1.6–3.2 mg/m3) of CS2 (8‐hour time‐weighted average [TWA]) was associated with detectable amounts of TTCA in end‐of‐shift urine. Moreover, the excretion of TTCA, relative to estimated CS2 uptake, appeared surprisingly constant in the studied work force. Approximately 3% (range 2–6.5%) of absorbed CS2 was detected in urine as TTCA. The proportional TTCA excretion did not show dose dependency in the estimated CS2 dose range which varied by about 20‐fold. TTCA elimination exhibited both a fast (T 1/2 6 hour) and a slow (T 1/2 68 hour) phase. The slow elimination is compatible with a high lipid solubility and reversible protein binding of CS2. Consequently, urinary excretion of TTCA, relative to CS2 exposure, increased by about a third during the workweek. Urinary TTCA concentration of 4.5 mmol/mol creatinine in a postshift sample corresponded to a TWA exposure to 10 ppm CS2 towards the end of the working week. © 1992 Wiley‐Liss, Inc.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>1415281</pmid><doi>10.1002/ajim.4700220108</doi><tpages>13</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0271-3586 |
| ispartof | American journal of industrial medicine, 1992, Vol.22 (1), p.85-97 |
| issn | 0271-3586 1097-0274 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Air Pollutants, Occupational - analysis ANIMALS AZOLES BIOLOGICAL MARKERS biological monitoring CARBON COMPOUNDS Carbon Disulfide - adverse effects Carbon Disulfide - analysis carbon disulfide TTCA CARBON SULFIDES CARBOXYLIC ACIDS CHALCOGENIDES CLEARANCE Environmental Monitoring EXCRETION Follow-Up Studies HAZARDS HEALTH HAZARDS HETEROCYCLIC COMPOUNDS Humans INDUSTRY Male MAMMALS MAN METABOLISM OCCUPATIONAL EXPOSURE Occupational Exposure - adverse effects Occupational Exposure - analysis ORGANIC ACIDS ORGANIC COMPOUNDS ORGANIC NITROGEN COMPOUNDS ORGANIC SULFUR COMPOUNDS PERSONNEL PRIMATES RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT reliable indicator Respiratory Protective Devices Sensitivity and Specificity SULFIDES SULFUR COMPOUNDS TEXTILE INDUSTRY THIAZOLES Thiazoles - urine Thiazolidines VERTEBRATES 560300 -- Chemicals Metabolism & Toxicology viscose rayon production |
| title | Assessment of exposure to carbon disulfide in viscose production workers from urinary 2-thiothiazolidine-4-carboxylic acid determinations |
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