Inhibition of oxytocin-induced but not angiotensin-induced rat uterine contractions following exposure to sodium sulfide

Low concentrations (0.15–15 μM) of sodium sulfide reversibly attenuated the contractile response of the isolated rat uterus to oxytocin without affecting angiotensin II responsiveness. These findings suggest that functionally important disulfide bonds in the rat uterine oxytocin receptor, but not th...

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Veröffentlicht in:	Life sciences (1973) 1989, Vol.45 (26), p.2557-2560
Hauptverfasser:	Hayden, L.J., Franklin, K.J., Roth, S.H., Moore, G.J.
Format:	Artikel
Sprache:	eng
Schlagworte:	ALKALI METAL COMPOUNDS ANGIOTENSIN Angiotensin II - antagonists & inhibitors Angiotensin Receptor Antagonists ANIMALS Biological and medical sciences BIOLOGICAL EFFECTS BODY CARDIOVASCULAR AGENTS CHALCOGENIDES CONTRACTION DRUGS Female FEMALE GENITALS Genital system. Reproduction GLOBULINS HORMONES In Vitro Techniques INHIBITION MAMMALS Medical sciences MEMBRANE PROTEINS ORGANIC COMPOUNDS ORGANS Oxygen Consumption OXYTOCIN Oxytocin - antagonists & inhibitors PEPTIDE HORMONES Pharmacology. Drug treatments PITUITARY HORMONES PROTEINS RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RATS Rats, Inbred Strains RECEPTORS Receptors, Angiotensin - metabolism Receptors, Oxytocin RODENTS SODIUM COMPOUNDS SODIUM SULFIDES SULFIDES Sulfides - pharmacology SULFUR COMPOUNDS Uterine Contraction - drug effects UTERUS VASOCONSTRICTORS VERTEBRATES 560300 > Chemicals Metabolism & Toxicology
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