Inhibition of oxytocin-induced but not angiotensin-induced rat uterine contractions following exposure to sodium sulfide

Low concentrations (0.15–15 μM) of sodium sulfide reversibly attenuated the contractile response of the isolated rat uterus to oxytocin without affecting angiotensin II responsiveness. These findings suggest that functionally important disulfide bonds in the rat uterine oxytocin receptor, but not th...

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Veröffentlicht in:Life sciences (1973) 1989, Vol.45 (26), p.2557-2560
Hauptverfasser: Hayden, L.J., Franklin, K.J., Roth, S.H., Moore, G.J.
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container_end_page 2560
container_issue 26
container_start_page 2557
container_title Life sciences (1973)
container_volume 45
creator Hayden, L.J.
Franklin, K.J.
Roth, S.H.
Moore, G.J.
description Low concentrations (0.15–15 μM) of sodium sulfide reversibly attenuated the contractile response of the isolated rat uterus to oxytocin without affecting angiotensin II responsiveness. These findings suggest that functionally important disulfide bonds in the rat uterine oxytocin receptor, but not the angiotensin receptor, are sensitive to hydrosulfide ion. Reduction of oxytocin receptors by hydrosulfide ion may be a mechanism by which low levels of H 2S delay parturition in rats.
doi_str_mv 10.1016/0024-3205(89)90239-7
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These findings suggest that functionally important disulfide bonds in the rat uterine oxytocin receptor, but not the angiotensin receptor, are sensitive to hydrosulfide ion. Reduction of oxytocin receptors by hydrosulfide ion may be a mechanism by which low levels of H 2S delay parturition in rats.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>2559275</pmid><doi>10.1016/0024-3205(89)90239-7</doi><tpages>4</tpages></addata></record>
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identifier ISSN: 0024-3205
ispartof Life sciences (1973), 1989, Vol.45 (26), p.2557-2560
issn 0024-3205
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language eng
recordid cdi_osti_scitechconnect_6853101
source MEDLINE; Access via ScienceDirect (Elsevier)
subjects ALKALI METAL COMPOUNDS
ANGIOTENSIN
Angiotensin II - antagonists & inhibitors
Angiotensin Receptor Antagonists
ANIMALS
Biological and medical sciences
BIOLOGICAL EFFECTS
BODY
CARDIOVASCULAR AGENTS
CHALCOGENIDES
CONTRACTION
DRUGS
Female
FEMALE GENITALS
Genital system. Reproduction
GLOBULINS
HORMONES
In Vitro Techniques
INHIBITION
MAMMALS
Medical sciences
MEMBRANE PROTEINS
ORGANIC COMPOUNDS
ORGANS
Oxygen Consumption
OXYTOCIN
Oxytocin - antagonists & inhibitors
PEPTIDE HORMONES
Pharmacology. Drug treatments
PITUITARY HORMONES
PROTEINS
RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT
RATS
Rats, Inbred Strains
RECEPTORS
Receptors, Angiotensin - metabolism
Receptors, Oxytocin
RODENTS
SODIUM COMPOUNDS
SODIUM SULFIDES
SULFIDES
Sulfides - pharmacology
SULFUR COMPOUNDS
Uterine Contraction - drug effects
UTERUS
VASOCONSTRICTORS
VERTEBRATES 560300 -- Chemicals Metabolism & Toxicology
title Inhibition of oxytocin-induced but not angiotensin-induced rat uterine contractions following exposure to sodium sulfide
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