Inhibition of oxytocin-induced but not angiotensin-induced rat uterine contractions following exposure to sodium sulfide
Low concentrations (0.15–15 μM) of sodium sulfide reversibly attenuated the contractile response of the isolated rat uterus to oxytocin without affecting angiotensin II responsiveness. These findings suggest that functionally important disulfide bonds in the rat uterine oxytocin receptor, but not th...
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| Veröffentlicht in: | Life sciences (1973) 1989, Vol.45 (26), p.2557-2560 |
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| container_title | Life sciences (1973) |
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| creator | Hayden, L.J. Franklin, K.J. Roth, S.H. Moore, G.J. |
| description | Low concentrations (0.15–15 μM) of sodium sulfide reversibly attenuated the contractile response of the isolated rat uterus to oxytocin without affecting angiotensin II responsiveness. These findings suggest that functionally important disulfide bonds in the rat uterine oxytocin receptor, but not the angiotensin receptor, are sensitive to hydrosulfide ion. Reduction of oxytocin receptors by hydrosulfide ion may be a mechanism by which low levels of H
2S delay parturition in rats. |
| doi_str_mv | 10.1016/0024-3205(89)90239-7 |
| format | Article |
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2S delay parturition in rats.</description><subject>ALKALI METAL COMPOUNDS</subject><subject>ANGIOTENSIN</subject><subject>Angiotensin II - antagonists & inhibitors</subject><subject>Angiotensin Receptor Antagonists</subject><subject>ANIMALS</subject><subject>Biological and medical sciences</subject><subject>BIOLOGICAL EFFECTS</subject><subject>BODY</subject><subject>CARDIOVASCULAR AGENTS</subject><subject>CHALCOGENIDES</subject><subject>CONTRACTION</subject><subject>DRUGS</subject><subject>Female</subject><subject>FEMALE GENITALS</subject><subject>Genital system. Reproduction</subject><subject>GLOBULINS</subject><subject>HORMONES</subject><subject>In Vitro Techniques</subject><subject>INHIBITION</subject><subject>MAMMALS</subject><subject>Medical sciences</subject><subject>MEMBRANE PROTEINS</subject><subject>ORGANIC COMPOUNDS</subject><subject>ORGANS</subject><subject>Oxygen Consumption</subject><subject>OXYTOCIN</subject><subject>Oxytocin - antagonists & inhibitors</subject><subject>PEPTIDE HORMONES</subject><subject>Pharmacology. Drug treatments</subject><subject>PITUITARY HORMONES</subject><subject>PROTEINS</subject><subject>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</subject><subject>RATS</subject><subject>Rats, Inbred Strains</subject><subject>RECEPTORS</subject><subject>Receptors, Angiotensin - metabolism</subject><subject>Receptors, Oxytocin</subject><subject>RODENTS</subject><subject>SODIUM COMPOUNDS</subject><subject>SODIUM SULFIDES</subject><subject>SULFIDES</subject><subject>Sulfides - pharmacology</subject><subject>SULFUR COMPOUNDS</subject><subject>Uterine Contraction - drug effects</subject><subject>UTERUS</subject><subject>VASOCONSTRICTORS</subject><subject>VERTEBRATES 560300 -- Chemicals Metabolism & Toxicology</subject><issn>0024-3205</issn><issn>1879-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUuLFDEUhYMoY8_oP1AIIoMuSvOsJBtBBh8DA250HVLJrZlIddImKe3591bZTeNKV3dxvns49x6EnlHyhhLavyWEiY4zIl9p89oQxk2nHqAN1cp0pOf0IdqckMfovNbvhBApFT9DZ0xKw5TcoP11uotDbDEnnEec9_ct-5i6mMLsIeBhbjjlhl26jblBqn9pxTU8NygxAfY5teL86lPxmKcp_4rpFsN-l-tcALeMaw5x3uI6T2MM8AQ9Gt1U4elxXqBvHz98vfrc3Xz5dH31_qbzQojWjc4r5XkAJznRxrNAqTSkl2TwZJBBB0I1FcobZbQZDA-Ea-GdZEzpIEd-gV4cfHNt0VYfG_i7JW0C32yvJV9-uUCXB2hX8o8ZarPbWD1Mk0uQ52qVEZJqIf4L0uW_WjKygOIA-pJrLTDaXYlbV-4tJXatz67d2LUbq439U59Vy9rzo_88bCGclo59LfrLo-6qd9NYXPKxnrC-N5qyNea7AwbLZ39GKOvhkJbSYlnvDjn-O8dvueq3jQ</recordid><startdate>1989</startdate><enddate>1989</enddate><creator>Hayden, L.J.</creator><creator>Franklin, K.J.</creator><creator>Roth, S.H.</creator><creator>Moore, G.J.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>M7Z</scope><scope>P64</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>1989</creationdate><title>Inhibition of oxytocin-induced but not angiotensin-induced rat uterine contractions following exposure to sodium sulfide</title><author>Hayden, L.J. ; Franklin, K.J. ; Roth, S.H. ; Moore, G.J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c444t-fac77c3dea53089c2d11590650bc0b5d8d018147c97989b93d0384ca52278d5f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>ALKALI METAL COMPOUNDS</topic><topic>ANGIOTENSIN</topic><topic>Angiotensin II - antagonists & inhibitors</topic><topic>Angiotensin Receptor Antagonists</topic><topic>ANIMALS</topic><topic>Biological and medical sciences</topic><topic>BIOLOGICAL EFFECTS</topic><topic>BODY</topic><topic>CARDIOVASCULAR AGENTS</topic><topic>CHALCOGENIDES</topic><topic>CONTRACTION</topic><topic>DRUGS</topic><topic>Female</topic><topic>FEMALE GENITALS</topic><topic>Genital system. Reproduction</topic><topic>GLOBULINS</topic><topic>HORMONES</topic><topic>In Vitro Techniques</topic><topic>INHIBITION</topic><topic>MAMMALS</topic><topic>Medical sciences</topic><topic>MEMBRANE PROTEINS</topic><topic>ORGANIC COMPOUNDS</topic><topic>ORGANS</topic><topic>Oxygen Consumption</topic><topic>OXYTOCIN</topic><topic>Oxytocin - antagonists & inhibitors</topic><topic>PEPTIDE HORMONES</topic><topic>Pharmacology. Drug treatments</topic><topic>PITUITARY HORMONES</topic><topic>PROTEINS</topic><topic>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. 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These findings suggest that functionally important disulfide bonds in the rat uterine oxytocin receptor, but not the angiotensin receptor, are sensitive to hydrosulfide ion. Reduction of oxytocin receptors by hydrosulfide ion may be a mechanism by which low levels of H
2S delay parturition in rats.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>2559275</pmid><doi>10.1016/0024-3205(89)90239-7</doi><tpages>4</tpages></addata></record> |
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| ispartof | Life sciences (1973), 1989, Vol.45 (26), p.2557-2560 |
| issn | 0024-3205 1879-0631 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | ALKALI METAL COMPOUNDS ANGIOTENSIN Angiotensin II - antagonists & inhibitors Angiotensin Receptor Antagonists ANIMALS Biological and medical sciences BIOLOGICAL EFFECTS BODY CARDIOVASCULAR AGENTS CHALCOGENIDES CONTRACTION DRUGS Female FEMALE GENITALS Genital system. Reproduction GLOBULINS HORMONES In Vitro Techniques INHIBITION MAMMALS Medical sciences MEMBRANE PROTEINS ORGANIC COMPOUNDS ORGANS Oxygen Consumption OXYTOCIN Oxytocin - antagonists & inhibitors PEPTIDE HORMONES Pharmacology. Drug treatments PITUITARY HORMONES PROTEINS RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RATS Rats, Inbred Strains RECEPTORS Receptors, Angiotensin - metabolism Receptors, Oxytocin RODENTS SODIUM COMPOUNDS SODIUM SULFIDES SULFIDES Sulfides - pharmacology SULFUR COMPOUNDS Uterine Contraction - drug effects UTERUS VASOCONSTRICTORS VERTEBRATES 560300 -- Chemicals Metabolism & Toxicology |
| title | Inhibition of oxytocin-induced but not angiotensin-induced rat uterine contractions following exposure to sodium sulfide |
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