Micronuclei formation in somatic cells of mice exposed to 50-Hz electric fields
Male Swiss mice are tested under uniform 50‐Hz electric field intensities of 100, 170, 220, and 290 kV/m. These values on the basis of equal induced current density are equivalent to the case of a human exposed to field intensities of nearly 8, 14, 18, and 24 kV/m, respectively. The latter values ma...
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| Veröffentlicht in: | Environmental and molecular mutagenesis 1989, Vol.13 (2), p.107-111 |
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| creator | El Nahas, Soheir M. Oraby, Hanaa A. |
| description | Male Swiss mice are tested under uniform 50‐Hz electric field intensities of 100, 170, 220, and 290 kV/m. These values on the basis of equal induced current density are equivalent to the case of a human exposed to field intensities of nearly 8, 14, 18, and 24 kV/m, respectively. The latter values may be found beneath or in vicinity of extra‐high‐voltage power lines whose voltages range from 220 to 765 kV. The cytogenetic effect of extremely low‐frequency (ELF) electric fields, as expressed by micronuclei formation, is assessed. Mice are exposed for 24 hr, and samples are taken 48, 72, and 96 hr from the beginning of exposure. Sham‐exposed mice served as controls. The number of micronucleated polychromatic erythrocytes (PCE) in exposed animals are significantly higher than those of the control. The increase in micronucleated PCE was significantly dose dependent at all times. Samples taken 96 hr after exposure show a decrease in percentages of micronucleated PCE, which may be taken as an indication of recovery. |
| doi_str_mv | 10.1002/em.2850130204 |
| format | Article |
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These values on the basis of equal induced current density are equivalent to the case of a human exposed to field intensities of nearly 8, 14, 18, and 24 kV/m, respectively. The latter values may be found beneath or in vicinity of extra‐high‐voltage power lines whose voltages range from 220 to 765 kV. The cytogenetic effect of extremely low‐frequency (ELF) electric fields, as expressed by micronuclei formation, is assessed. Mice are exposed for 24 hr, and samples are taken 48, 72, and 96 hr from the beginning of exposure. Sham‐exposed mice served as controls. The number of micronucleated polychromatic erythrocytes (PCE) in exposed animals are significantly higher than those of the control. The increase in micronucleated PCE was significantly dose dependent at all times. Samples taken 96 hr after exposure show a decrease in percentages of micronucleated PCE, which may be taken as an indication of recovery.</description><identifier>ISSN: 0893-6692</identifier><identifier>EISSN: 1098-2280</identifier><identifier>DOI: 10.1002/em.2850130204</identifier><identifier>PMID: 2917550</identifier><identifier>CODEN: EMMUEG</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>ANIMAL CELLS ; ANIMALS ; Biological and medical sciences ; BIOLOGICAL EFFECTS ; BIOLOGICAL MATERIALS ; BIOLOGY ; BLOOD ; BLOOD CELLS ; BODY FLUIDS ; BONE MARROW CELLS ; CELL CONSTITUENTS ; CELL NUCLEI ; Cell Nucleus - ultrastructure ; Chemical mutagenesis ; clastogenic effect ; CONNECTIVE TISSUE CELLS ; CYTOLOGY ; DOSE-RESPONSE RELATIONSHIPS ; ELECTRIC FIELDS ; ELECTRIC POTENTIAL ; Electricity - adverse effects ; ERYTHROCYTES ; Erythrocytes - ultrastructure ; extremely low-frequency electric fields ; FREQUENCY RANGE ; Fundamental and applied biological sciences. Psychology ; HZ RANGE ; Male ; MAMMALS ; MATERIALS ; Medical sciences ; MICE ; micronucleated polychromatic erythrocytes ; Molecular and cellular biology ; Molecular genetics ; MUTAGENESIS ; Mutagenesis. Repair ; Mutation ; RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. 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Mol. Mutagen</addtitle><description>Male Swiss mice are tested under uniform 50‐Hz electric field intensities of 100, 170, 220, and 290 kV/m. These values on the basis of equal induced current density are equivalent to the case of a human exposed to field intensities of nearly 8, 14, 18, and 24 kV/m, respectively. The latter values may be found beneath or in vicinity of extra‐high‐voltage power lines whose voltages range from 220 to 765 kV. The cytogenetic effect of extremely low‐frequency (ELF) electric fields, as expressed by micronuclei formation, is assessed. Mice are exposed for 24 hr, and samples are taken 48, 72, and 96 hr from the beginning of exposure. Sham‐exposed mice served as controls. The number of micronucleated polychromatic erythrocytes (PCE) in exposed animals are significantly higher than those of the control. The increase in micronucleated PCE was significantly dose dependent at all times. Samples taken 96 hr after exposure show a decrease in percentages of micronucleated PCE, which may be taken as an indication of recovery.</description><subject>ANIMAL CELLS</subject><subject>ANIMALS</subject><subject>Biological and medical sciences</subject><subject>BIOLOGICAL EFFECTS</subject><subject>BIOLOGICAL MATERIALS</subject><subject>BIOLOGY</subject><subject>BLOOD</subject><subject>BLOOD CELLS</subject><subject>BODY FLUIDS</subject><subject>BONE MARROW CELLS</subject><subject>CELL CONSTITUENTS</subject><subject>CELL NUCLEI</subject><subject>Cell Nucleus - ultrastructure</subject><subject>Chemical mutagenesis</subject><subject>clastogenic effect</subject><subject>CONNECTIVE TISSUE CELLS</subject><subject>CYTOLOGY</subject><subject>DOSE-RESPONSE RELATIONSHIPS</subject><subject>ELECTRIC FIELDS</subject><subject>ELECTRIC POTENTIAL</subject><subject>Electricity - adverse effects</subject><subject>ERYTHROCYTES</subject><subject>Erythrocytes - ultrastructure</subject><subject>extremely low-frequency electric fields</subject><subject>FREQUENCY RANGE</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>HZ RANGE</subject><subject>Male</subject><subject>MAMMALS</subject><subject>MATERIALS</subject><subject>Medical sciences</subject><subject>MICE</subject><subject>micronucleated polychromatic erythrocytes</subject><subject>Molecular and cellular biology</subject><subject>Molecular genetics</subject><subject>MUTAGENESIS</subject><subject>Mutagenesis. Repair</subject><subject>Mutation</subject><subject>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</subject><subject>RODENTS</subject><subject>SOMATIC CELLS</subject><subject>Toxicology</subject><subject>VERTEBRATES 560400 -- Other Environmental Pollutant Effects</subject><issn>0893-6692</issn><issn>1098-2280</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1vFDEMhiMEKkvhyBEpQhW3KXEymSRHVNouoqWA-DhG2YwjAjOTJZkVLb-eWe10Ky5wsiU_fv3aJuQpsGNgjL_E_phryUAwzup7ZAHM6Ipzze6TBdNGVE1j-EPyqJTvjAHUhh-QA25ASckW5Ooy-pyGje8w0pBy78aYBhoHWtI299Rj1xWaAu2jR4rX61SwpWOiklXL3xQ79GOeuBCxa8tj8iC4ruCTOR6Sz2enn06W1cXV-ZuTVxeVl1zVFQotW8NWba0CALp61UpQbV1r44X0wXCo2bQIeKO4CDpo9E5Jx5UKMngmDsnznW4qY7TFxxH9N5-GYXJjGy2gATNBL3bQOqefGyyj7WPZ7uMGTJtildbKaAP_BUGKW7DagdPRSskY7DrH3uUbC8xu32Gxt3fvmPhns_Bm1WO7p-f7T_Wjue6Kd13IbvCx7DHFG2PMVkbtsF-xw5t_z7Snl38ZmA3HMuL1vtPlH7ZRQkn79d25XX55K16b9x_sR_EHc7KvGg</recordid><startdate>1989</startdate><enddate>1989</enddate><creator>El Nahas, Soheir M.</creator><creator>Oraby, Hanaa A.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>1989</creationdate><title>Micronuclei formation in somatic cells of mice exposed to 50-Hz electric fields</title><author>El Nahas, Soheir M. ; Oraby, Hanaa A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5274-e385d90bd47f11ea4bd517d4489c35cf921400981c9723f8f8eca75a277f5fc03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>ANIMAL CELLS</topic><topic>ANIMALS</topic><topic>Biological and medical sciences</topic><topic>BIOLOGICAL EFFECTS</topic><topic>BIOLOGICAL MATERIALS</topic><topic>BIOLOGY</topic><topic>BLOOD</topic><topic>BLOOD CELLS</topic><topic>BODY FLUIDS</topic><topic>BONE MARROW CELLS</topic><topic>CELL CONSTITUENTS</topic><topic>CELL NUCLEI</topic><topic>Cell Nucleus - ultrastructure</topic><topic>Chemical mutagenesis</topic><topic>clastogenic effect</topic><topic>CONNECTIVE TISSUE CELLS</topic><topic>CYTOLOGY</topic><topic>DOSE-RESPONSE RELATIONSHIPS</topic><topic>ELECTRIC FIELDS</topic><topic>ELECTRIC POTENTIAL</topic><topic>Electricity - adverse effects</topic><topic>ERYTHROCYTES</topic><topic>Erythrocytes - ultrastructure</topic><topic>extremely low-frequency electric fields</topic><topic>FREQUENCY RANGE</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>HZ RANGE</topic><topic>Male</topic><topic>MAMMALS</topic><topic>MATERIALS</topic><topic>Medical sciences</topic><topic>MICE</topic><topic>micronucleated polychromatic erythrocytes</topic><topic>Molecular and cellular biology</topic><topic>Molecular genetics</topic><topic>MUTAGENESIS</topic><topic>Mutagenesis. Repair</topic><topic>Mutation</topic><topic>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</topic><topic>RODENTS</topic><topic>SOMATIC CELLS</topic><topic>Toxicology</topic><topic>VERTEBRATES 560400 -- Other Environmental Pollutant Effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>El Nahas, Soheir M.</creatorcontrib><creatorcontrib>Oraby, Hanaa A.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>Environmental and molecular mutagenesis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>El Nahas, Soheir M.</au><au>Oraby, Hanaa A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Micronuclei formation in somatic cells of mice exposed to 50-Hz electric fields</atitle><jtitle>Environmental and molecular mutagenesis</jtitle><addtitle>Environ. Mol. Mutagen</addtitle><date>1989</date><risdate>1989</risdate><volume>13</volume><issue>2</issue><spage>107</spage><epage>111</epage><pages>107-111</pages><issn>0893-6692</issn><eissn>1098-2280</eissn><coden>EMMUEG</coden><abstract>Male Swiss mice are tested under uniform 50‐Hz electric field intensities of 100, 170, 220, and 290 kV/m. These values on the basis of equal induced current density are equivalent to the case of a human exposed to field intensities of nearly 8, 14, 18, and 24 kV/m, respectively. The latter values may be found beneath or in vicinity of extra‐high‐voltage power lines whose voltages range from 220 to 765 kV. The cytogenetic effect of extremely low‐frequency (ELF) electric fields, as expressed by micronuclei formation, is assessed. Mice are exposed for 24 hr, and samples are taken 48, 72, and 96 hr from the beginning of exposure. Sham‐exposed mice served as controls. The number of micronucleated polychromatic erythrocytes (PCE) in exposed animals are significantly higher than those of the control. The increase in micronucleated PCE was significantly dose dependent at all times. Samples taken 96 hr after exposure show a decrease in percentages of micronucleated PCE, which may be taken as an indication of recovery.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>2917550</pmid><doi>10.1002/em.2850130204</doi><tpages>5</tpages></addata></record> |
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| ispartof | Environmental and molecular mutagenesis, 1989, Vol.13 (2), p.107-111 |
| issn | 0893-6692 1098-2280 |
| language | eng |
| recordid | cdi_osti_scitechconnect_6831619 |
| source | MEDLINE; Access via Wiley Online Library |
| subjects | ANIMAL CELLS ANIMALS Biological and medical sciences BIOLOGICAL EFFECTS BIOLOGICAL MATERIALS BIOLOGY BLOOD BLOOD CELLS BODY FLUIDS BONE MARROW CELLS CELL CONSTITUENTS CELL NUCLEI Cell Nucleus - ultrastructure Chemical mutagenesis clastogenic effect CONNECTIVE TISSUE CELLS CYTOLOGY DOSE-RESPONSE RELATIONSHIPS ELECTRIC FIELDS ELECTRIC POTENTIAL Electricity - adverse effects ERYTHROCYTES Erythrocytes - ultrastructure extremely low-frequency electric fields FREQUENCY RANGE Fundamental and applied biological sciences. Psychology HZ RANGE Male MAMMALS MATERIALS Medical sciences MICE micronucleated polychromatic erythrocytes Molecular and cellular biology Molecular genetics MUTAGENESIS Mutagenesis. Repair Mutation RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RODENTS SOMATIC CELLS Toxicology VERTEBRATES 560400 -- Other Environmental Pollutant Effects |
| title | Micronuclei formation in somatic cells of mice exposed to 50-Hz electric fields |
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