Cyclic Cholecystokinin Analogues with High Selectivity for Central Receptors

Taking as a model the N-terminal folding of the cholecystokinin tyrosine-sulfated octapeptide [CCK-8; Asp-Tyr-(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH$_{2}$] deduced from conformational studies, two cyclic cholecystokinin (CCK) analogues were synthesized by conventional peptide synthesis: Boc-D-A$\overline...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1988-03, Vol.85 (6), p.1968-1972
Hauptverfasser:	Charpentier, Bruno, Pelaprat, Didier, Durieux, Christiane, Dor, Adeline, Reibaud, Michel, Blanchard, Jean-Charles, Roques, Bernard P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids ANIMALS BASIC BIOLOGICAL SCIENCES BETA DECAY RADIOISOTOPES Binding sites BIOCHEMICAL REACTION KINETICS Biological and medical sciences BODY BRAIN CENTRAL NERVOUS SYSTEM Central neurotransmission. Neuromudulation. Pathways and receptors Cerebral Cortex - metabolism CHEMICAL REACTIONS Cholecystokinin - analogs & derivatives Cholecystokinin - metabolism Cholecystokinin receptors CROSS-LINKING DAYS LIVING RADIOISOTOPES ELECTRON CAPTURE RADIOISOTOPES ELECTROPHORESIS Fundamental and applied biological sciences. Psychology GUINEA PIGS HYDROGEN COMPOUNDS Ileum INHIBITION Inhibitory concentration 50 INTERMEDIATE MASS NUCLEI IODINE 125 IODINE ISOTOPES ISOTOPES KINETICS KININS LABELLED COMPOUNDS LIGANDS Male MAMMALS MEMBRANE PROTEINS Membranes - metabolism MOLECULAR STRUCTURE NERVOUS SYSTEM NUCLEI ODD-EVEN NUCLEI ORGANIC COMPOUNDS ORGANS P branes Pancreas PEPTIDES Pharmacology POLYMERIZATION POLYPEPTIDES PROTEINS RADIOISOTOPES REACTION KINETICS RECEPTORS Receptors, Cholecystokinin - metabolism RODENTS TRITIUM COMPOUNDS VERTEBRATES 550201 > Biochemistry-- Tracer Techniques Vertebrates: nervous system and sense organs
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!