Activation of the Protein-Tyrosine Kinase Associated with the Bombesin Receptor Complex in Small Cell Lung Carcinomas

It has been hypothesized that bombesin-like peptides produced by small cell lung carcinomas may sustain deregulated proliferation through an autocrine mechanism. We have shown that the neuropeptide bombesin leads to the activation of a protein-tyrosine kinase that phosphorylates a 115-kDa protein (p...

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Veröffentlicht in:Proceedings of the National Academy of Sciences - PNAS 1988-04, Vol.85 (7), p.2166-2170
Hauptverfasser: Gaudino, G., Cirillo, D., Naldini, L., Rossino, P., Comoglio, P. M.
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Sprache:eng
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