Interactions of water contaminants. I : Plasma enzyme activity and response surface methodology following gavage administration of CCl4 and CHCl3 or TCE singly and in combination in the rat

The joint hepatotoxicity of CCl4 and CHCl3 or TCE in male CD rats following simultaneous oral administration has been investigated. Rats with chronic indwelling arterial cannulas were administered a single oral dose of CCl4 and CHCl3 or CCl4 and TCE in 5% Emulphor at doses of 0 to 700 mg/kg. Hepatot...

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Veröffentlicht in:	Fundamental and applied toxicology 1990-04, Vol.14 (3), p.477-490
Hauptverfasser:	BORZELLECA, J. F, O'HARA, T. M, GENNINGS, C, GRANGER, R. H, SHEPPARD, M. A, CONDIE, L. W. JR
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine Transaminase - blood AMINOTRANSFERASES ANIMALS Aspartate Aminotransferases - blood Biological and medical sciences CARBON TETRACHLORIDE Carbon Tetrachloride Poisoning - enzymology Chemical and Drug Induced Liver Injury - enzymology CHLORINATED ALIPHATIC HYDROCARBONS CHLOROFORM Chloroform - poisoning DIGESTIVE SYSTEM DISEASES DISEASES DOSE-RESPONSE RELATIONSHIPS ENZYME ACTIVITY ENZYMES Enzymes - blood Food toxicology HALOGENATED ALIPHATIC HYDROCARBONS HEPATITIS L-Iditol 2-Dehydrogenase - blood Male MAMMALS Medical sciences NITROGEN TRANSFERASES ORAL ADMINISTRATION ORGANIC CHLORINE COMPOUNDS ORGANIC COMPOUNDS ORGANIC HALOGEN COMPOUNDS OXIDOREDUCTASES POLLUTION RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RATS Rats, Inbred Strains RODENTS SYNERGISM TOXICITY Toxicology TRANSFERASES Trichloroethylene - poisoning VERTEBRATES 560300 > Chemicals Metabolism & Toxicology Water Pollutants - toxicity WATER POLLUTION
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