Binding modes of distamycin A with d(CGCAAATTTGCG) sub 2 determined by two-dimensional NMR

Two-dimensional nuclear Overhauser effect spectroscopy (NOESY) was used to study the interaction of distamycin A with d(CGCAAATTTGCG){sub 2}. Spectra acquired at several points in a titration of the dodecamer with distamycin A were used to assign resonances, to determine drug-drug and drug-DNA conta...

Ausführliche Beschreibung