Recurrent medulloblastoma: frequency of tumor enhancement on Gd-DTPA MR imaging
Thirty-two children with medulloblastoma were evaluated postoperatively with conventional and gadolinium-enhanced MR imaging. Eleven patients had abnormal cranial MR studies; nine of these had recurrent tumor. In six patients recurrent tumor enhanced with Gd, while in the other three patients recurr...
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| Veröffentlicht in: | American journal of roentgenology (1976) 1990-07, Vol.155 (1), p.153-157 |
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| container_title | American journal of roentgenology (1976) |
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| creator | Rollins, N Mendelsohn, D Mulne, A Barton, R Diehl, J Reyes, N Sklar, F |
| description | Thirty-two children with medulloblastoma were evaluated postoperatively with conventional and gadolinium-enhanced MR imaging. Eleven patients had abnormal cranial MR studies; nine of these had recurrent tumor. In six patients recurrent tumor enhanced with Gd, while in the other three patients recurrent tumor did not enhance. The remaining two patients had areas of abnormal Gd enhancement that were caused by radiation-induced breakdown of the blood-brain barrier rather than by recurrent tumor. This study shows that not all recurrent medulloblastoma enhances and that the absence of Gd enhancement does not necessarily indicate the absence of recurrent tumor. |
| doi_str_mv | 10.2214/ajr.155.1.2112838 |
| format | Article |
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Eleven patients had abnormal cranial MR studies; nine of these had recurrent tumor. In six patients recurrent tumor enhanced with Gd, while in the other three patients recurrent tumor did not enhance. The remaining two patients had areas of abnormal Gd enhancement that were caused by radiation-induced breakdown of the blood-brain barrier rather than by recurrent tumor. This study shows that not all recurrent medulloblastoma enhances and that the absence of Gd enhancement does not necessarily indicate the absence of recurrent tumor.</description><identifier>ISSN: 0361-803X</identifier><identifier>EISSN: 1546-3141</identifier><identifier>DOI: 10.2214/ajr.155.1.2112838</identifier><identifier>PMID: 2112838</identifier><language>eng</language><publisher>United States: Am Roentgen Ray Soc</publisher><subject>Adolescent ; AGE GROUPS ; AMINO ACIDS ; BLOOD-BRAIN BARRIER ; Blood-Brain Barrier - radiation effects ; BODY ; BRAIN ; CARBOXYLIC ACIDS ; CENTRAL NERVOUS SYSTEM ; Cerebellar Neoplasms - diagnosis ; CHELATING AGENTS ; Child ; Child, Preschool ; CHILDREN ; CONTRAST MEDIA ; DIAGNOSIS ; DIAGNOSTIC TECHNIQUES ; DISEASES ; DRUGS ; DTPA ; Gadolinium DTPA ; Humans ; Image Enhancement - methods ; Infant ; MAGNETIC RESONANCE ; Magnetic Resonance Imaging - methods ; Medulloblastoma - diagnosis ; NECROSIS ; Neoplasm Recurrence, Local - diagnosis ; NEOPLASMS ; NERVOUS SYSTEM ; NMR IMAGING ; NUCLEAR MAGNETIC RESONANCE ; ORGANIC ACIDS ; ORGANIC COMPOUNDS ; Organometallic Compounds ; ORGANS ; PATHOLOGICAL CHANGES ; PATIENTS ; Pentetic Acid ; Radiation Injuries - diagnosis ; RADIOLOGY AND NUCLEAR MEDICINE ; RADIOPROTECTIVE SUBSTANCES ; RESONANCE 550601 -- Medicine-- Unsealed Radionuclides in Diagnostics ; Tomography, X-Ray Computed</subject><ispartof>American journal of roentgenology (1976), 1990-07, Vol.155 (1), p.153-157</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c354t-bc48bedf71efbf3e516cd675d57e1c032398acd0a5ab5fba642246dc1c3f5fb03</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,4120,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2112838$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/6707291$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Rollins, N</creatorcontrib><creatorcontrib>Mendelsohn, D</creatorcontrib><creatorcontrib>Mulne, A</creatorcontrib><creatorcontrib>Barton, R</creatorcontrib><creatorcontrib>Diehl, J</creatorcontrib><creatorcontrib>Reyes, N</creatorcontrib><creatorcontrib>Sklar, F</creatorcontrib><title>Recurrent medulloblastoma: frequency of tumor enhancement on Gd-DTPA MR imaging</title><title>American journal of roentgenology (1976)</title><addtitle>AJR Am J Roentgenol</addtitle><description>Thirty-two children with medulloblastoma were evaluated postoperatively with conventional and gadolinium-enhanced MR imaging. Eleven patients had abnormal cranial MR studies; nine of these had recurrent tumor. In six patients recurrent tumor enhanced with Gd, while in the other three patients recurrent tumor did not enhance. The remaining two patients had areas of abnormal Gd enhancement that were caused by radiation-induced breakdown of the blood-brain barrier rather than by recurrent tumor. This study shows that not all recurrent medulloblastoma enhances and that the absence of Gd enhancement does not necessarily indicate the absence of recurrent tumor.</description><subject>Adolescent</subject><subject>AGE GROUPS</subject><subject>AMINO ACIDS</subject><subject>BLOOD-BRAIN BARRIER</subject><subject>Blood-Brain Barrier - radiation effects</subject><subject>BODY</subject><subject>BRAIN</subject><subject>CARBOXYLIC ACIDS</subject><subject>CENTRAL NERVOUS SYSTEM</subject><subject>Cerebellar Neoplasms - diagnosis</subject><subject>CHELATING AGENTS</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>CHILDREN</subject><subject>CONTRAST MEDIA</subject><subject>DIAGNOSIS</subject><subject>DIAGNOSTIC TECHNIQUES</subject><subject>DISEASES</subject><subject>DRUGS</subject><subject>DTPA</subject><subject>Gadolinium DTPA</subject><subject>Humans</subject><subject>Image Enhancement - methods</subject><subject>Infant</subject><subject>MAGNETIC RESONANCE</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Medulloblastoma - diagnosis</subject><subject>NECROSIS</subject><subject>Neoplasm Recurrence, Local - diagnosis</subject><subject>NEOPLASMS</subject><subject>NERVOUS SYSTEM</subject><subject>NMR IMAGING</subject><subject>NUCLEAR MAGNETIC RESONANCE</subject><subject>ORGANIC ACIDS</subject><subject>ORGANIC COMPOUNDS</subject><subject>Organometallic Compounds</subject><subject>ORGANS</subject><subject>PATHOLOGICAL CHANGES</subject><subject>PATIENTS</subject><subject>Pentetic Acid</subject><subject>Radiation Injuries - diagnosis</subject><subject>RADIOLOGY AND NUCLEAR MEDICINE</subject><subject>RADIOPROTECTIVE SUBSTANCES</subject><subject>RESONANCE 550601 -- Medicine-- Unsealed Radionuclides in Diagnostics</subject><subject>Tomography, X-Ray Computed</subject><issn>0361-803X</issn><issn>1546-3141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkNFKwzAUhoMoc04fwAuheOFda07TtJ13Y-oUJpMxwbuQpsna0aYzaSl7ezM69OpwON__c_gQugUchCFEj3xnAqA0gCAECFOSnqEx0Cj2CURwjsaYxOCnmHxfoitrdxjjJJ0mIzQ64WO0WkvRGSN169Uy76qqySpu26bmT54y8qeTWhy8RnltVzfGk7rgWsj6yDfaW-T-8-Zz5n2svbLm21Jvr9GF4pWVN6c5QV-vL5v5m79cLd7ns6UvCI1aPxNRmslcJSBVpoikEIs8TmhOEwkCk5BMUy5yzCnPqMp4HIVhFOcCBFFux2SC7ofexrYls6JspShEo7UULYsTnIRTcBAMkDCNtUYqtjfuT3NggNlRIHMCmRPIgJ2MuMzdkNl3mTPyl_i_Pwz3otwWfWkkszWvKkcD6_t-KANKyC8MZHok</recordid><startdate>19900701</startdate><enddate>19900701</enddate><creator>Rollins, N</creator><creator>Mendelsohn, D</creator><creator>Mulne, A</creator><creator>Barton, R</creator><creator>Diehl, J</creator><creator>Reyes, N</creator><creator>Sklar, F</creator><general>Am Roentgen Ray Soc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>OTOTI</scope></search><sort><creationdate>19900701</creationdate><title>Recurrent medulloblastoma: frequency of tumor enhancement on Gd-DTPA MR imaging</title><author>Rollins, N ; Mendelsohn, D ; Mulne, A ; Barton, R ; Diehl, J ; Reyes, N ; Sklar, F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c354t-bc48bedf71efbf3e516cd675d57e1c032398acd0a5ab5fba642246dc1c3f5fb03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Adolescent</topic><topic>AGE GROUPS</topic><topic>AMINO ACIDS</topic><topic>BLOOD-BRAIN BARRIER</topic><topic>Blood-Brain Barrier - radiation effects</topic><topic>BODY</topic><topic>BRAIN</topic><topic>CARBOXYLIC ACIDS</topic><topic>CENTRAL NERVOUS SYSTEM</topic><topic>Cerebellar Neoplasms - diagnosis</topic><topic>CHELATING AGENTS</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>CHILDREN</topic><topic>CONTRAST MEDIA</topic><topic>DIAGNOSIS</topic><topic>DIAGNOSTIC TECHNIQUES</topic><topic>DISEASES</topic><topic>DRUGS</topic><topic>DTPA</topic><topic>Gadolinium DTPA</topic><topic>Humans</topic><topic>Image Enhancement - methods</topic><topic>Infant</topic><topic>MAGNETIC RESONANCE</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Medulloblastoma - diagnosis</topic><topic>NECROSIS</topic><topic>Neoplasm Recurrence, Local - diagnosis</topic><topic>NEOPLASMS</topic><topic>NERVOUS SYSTEM</topic><topic>NMR IMAGING</topic><topic>NUCLEAR MAGNETIC RESONANCE</topic><topic>ORGANIC ACIDS</topic><topic>ORGANIC COMPOUNDS</topic><topic>Organometallic Compounds</topic><topic>ORGANS</topic><topic>PATHOLOGICAL CHANGES</topic><topic>PATIENTS</topic><topic>Pentetic Acid</topic><topic>Radiation Injuries - diagnosis</topic><topic>RADIOLOGY AND NUCLEAR MEDICINE</topic><topic>RADIOPROTECTIVE SUBSTANCES</topic><topic>RESONANCE 550601 -- Medicine-- Unsealed Radionuclides in Diagnostics</topic><topic>Tomography, X-Ray Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rollins, N</creatorcontrib><creatorcontrib>Mendelsohn, D</creatorcontrib><creatorcontrib>Mulne, A</creatorcontrib><creatorcontrib>Barton, R</creatorcontrib><creatorcontrib>Diehl, J</creatorcontrib><creatorcontrib>Reyes, N</creatorcontrib><creatorcontrib>Sklar, F</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>OSTI.GOV</collection><jtitle>American journal of roentgenology (1976)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rollins, N</au><au>Mendelsohn, D</au><au>Mulne, A</au><au>Barton, R</au><au>Diehl, J</au><au>Reyes, N</au><au>Sklar, F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Recurrent medulloblastoma: frequency of tumor enhancement on Gd-DTPA MR imaging</atitle><jtitle>American journal of roentgenology (1976)</jtitle><addtitle>AJR Am J Roentgenol</addtitle><date>1990-07-01</date><risdate>1990</risdate><volume>155</volume><issue>1</issue><spage>153</spage><epage>157</epage><pages>153-157</pages><issn>0361-803X</issn><eissn>1546-3141</eissn><abstract>Thirty-two children with medulloblastoma were evaluated postoperatively with conventional and gadolinium-enhanced MR imaging. Eleven patients had abnormal cranial MR studies; nine of these had recurrent tumor. In six patients recurrent tumor enhanced with Gd, while in the other three patients recurrent tumor did not enhance. The remaining two patients had areas of abnormal Gd enhancement that were caused by radiation-induced breakdown of the blood-brain barrier rather than by recurrent tumor. This study shows that not all recurrent medulloblastoma enhances and that the absence of Gd enhancement does not necessarily indicate the absence of recurrent tumor.</abstract><cop>United States</cop><pub>Am Roentgen Ray Soc</pub><pmid>2112838</pmid><doi>10.2214/ajr.155.1.2112838</doi><tpages>5</tpages></addata></record> |
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| ispartof | American journal of roentgenology (1976), 1990-07, Vol.155 (1), p.153-157 |
| issn | 0361-803X 1546-3141 |
| language | eng |
| recordid | cdi_osti_scitechconnect_6707291 |
| source | American Roentgen Ray Society; MEDLINE; Alma/SFX Local Collection |
| subjects | Adolescent AGE GROUPS AMINO ACIDS BLOOD-BRAIN BARRIER Blood-Brain Barrier - radiation effects BODY BRAIN CARBOXYLIC ACIDS CENTRAL NERVOUS SYSTEM Cerebellar Neoplasms - diagnosis CHELATING AGENTS Child Child, Preschool CHILDREN CONTRAST MEDIA DIAGNOSIS DIAGNOSTIC TECHNIQUES DISEASES DRUGS DTPA Gadolinium DTPA Humans Image Enhancement - methods Infant MAGNETIC RESONANCE Magnetic Resonance Imaging - methods Medulloblastoma - diagnosis NECROSIS Neoplasm Recurrence, Local - diagnosis NEOPLASMS NERVOUS SYSTEM NMR IMAGING NUCLEAR MAGNETIC RESONANCE ORGANIC ACIDS ORGANIC COMPOUNDS Organometallic Compounds ORGANS PATHOLOGICAL CHANGES PATIENTS Pentetic Acid Radiation Injuries - diagnosis RADIOLOGY AND NUCLEAR MEDICINE RADIOPROTECTIVE SUBSTANCES RESONANCE 550601 -- Medicine-- Unsealed Radionuclides in Diagnostics Tomography, X-Ray Computed |
| title | Recurrent medulloblastoma: frequency of tumor enhancement on Gd-DTPA MR imaging |
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