Sigma and opioid receptors in human brain tumors

Human brain tumors (obtained as surgical specimens) and nude mouse-borne human neuroblastomas and gliomas were analyzed for sigma and opioid receptor content. Sigma binding was assessed using [ 3H] 1, 3-di- o -tolylguanidine (DTG), whereas opioid receptor subtypes were measured with tritiated forms...

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Veröffentlicht in:	Life sciences (1973) 1990, Vol.46 (18), p.1279-1286
Hauptverfasser:	Thomas, Gail E., Szücs, Maria, Mamone, James Y., Bem, Wojciech T., Rush, Michael D., Johnson, Frank E., Coscia, Carmine J.
Format:	Artikel
Sprache:	eng
Schlagworte:	550901 > Pathology-- Tracer Techniques Adenocarcinoma - analysis Adenocarcinoma - secondary Analgesics, Opioid - metabolism ANIMALS Astrocytoma - analysis AUTONOMIC NERVOUS SYSTEM AGENTS BASIC BIOLOGICAL SCIENCES BIOCHEMICAL REACTION KINETICS Biological and medical sciences BODY BRAIN Brain Neoplasms - analysis Brain Neoplasms - secondary CENTRAL NERVOUS SYSTEM COMPUTER CODES Cyclazocine - analogs & derivatives Cyclazocine - metabolism DISEASES DRUGS ENDORPHINS Ethylketocyclazocine Glioblastoma - analysis Glioma - analysis Humans HYDROGEN COMPOUNDS ISOTOPE APPLICATIONS KINETICS L CODES Male MAMMALS MAN Medical sciences MEMBRANE PROTEINS METASTASES Mice Mice, Nude NEOPLASMS NERVOUS SYSTEM Neuroblastoma - analysis NEUROREGULATORS ORGANIC COMPOUNDS ORGANS PRIMATES PROTEINS Radioligand Assay Rats REACTION KINETICS RECEPTORS Receptors, Opioid - analysis Receptors, sigma TRACER TECHNIQUES TRITIUM COMPOUNDS Tumors VERTEBRATES 550201 > Biochemistry-- Tracer Techniques
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