Synthesis of [11,11,12,12- 2H 4]progesterone for mass spectral investigations of peripheral metabolism

Hecogenin has been transformed into [11 ,11 ,12,12- 2H 4]progesterone via base-catalyzed isotope exchange with D 2O (at C-11), carbenic decomposition of the 12-tosylhydrazone formed by the use of [N,N,N'- 2H 3]toluene-p-sulfonylhydrazine, and reduction with [ 2H 2]diimide to give [11,11,12,12-...

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Veröffentlicht in:	Steroids 1990-05, Vol.55 (5), p.222-227
Hauptverfasser:	Kirk, David N., Smith, Carmen Z., Honour, John W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry BASIC BIOLOGICAL SCIENCES Biological and medical sciences CHEMICAL PREPARATION deoxycorticosterone metabolism Desoxycorticosterone - metabolism DEUTERIUM deuterium labeling deuterium-labeled hecogenin deuterium-labeled progesterone Fundamental and applied biological sciences. Psychology HORMONES HYDROGEN ISOTOPES ISOTOPE APPLICATIONS Isotope Labeling - methods ISOTOPES ISOTOPIC EXCHANGE KETONES LABELLING LIGHT NUCLEI MASS SPECTRA Mass Spectrometry METABOLISM NUCLEI ODD-ODD NUCLEI ORGANIC COMPOUNDS Other biological molecules Oxidation-Reduction PREGNANES PROGESTERONE Progesterone - chemical synthesis Progesterone - metabolism SPECTRA STABLE ISOTOPES STEROID HORMONES STEROIDS SYNTHESIS 550501 > Metabolism-- Tracer Techniques Terpenes, steroids. Hormones TRACER TECHNIQUES
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