Indium-111-Granulocyte Scintigraphy in Brain Abscess Diagnosis: Limitations and Pitfalls
The scintigrams and records of 28 patients referred for indium-111-granulocyte scintigraphy (111In-GS) because of a suspected brain abscess were studied retrospectively. The final diagnosis was brain abscess in 8 patients, brain tumor in 18 patients, and infarct and hematoma in 1 patient each. Five...
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| Veröffentlicht in: | The Journal of nuclear medicine (1978) 1990-07, Vol.31 (7), p.1121-1127 |
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| creator | Schmidt, Kai G Rasmussen, Jens W Frederiksen, Povl B Kock-Jensen, Carsten Pedersen, Niels T |
| description | The scintigrams and records of 28 patients referred for indium-111-granulocyte scintigraphy (111In-GS) because of a suspected brain abscess were studied retrospectively. The final diagnosis was brain abscess in 8 patients, brain tumor in 18 patients, and infarct and hematoma in 1 patient each. Five patients not on corticosteroid treatment showed intense focal 111In accumulation in abscesses, whereas an abscess patient receiving a high steroid dose showed no uptake. Two patients studied twice showed intense uptake in abscesses when not on steroid therapy or on a low dose, whereas no uptake was seen when they received high or medium doses. Weak or moderate 111In uptake was observed in nine tumors. Microscopically assessed degree of tumor granulocyte infiltration, vessel proliferation, and hemorrhage did not correlate with the outcome of 111In GS. Our results suggest that intense focal cerebral 111In uptake favors the abscess diagnosis. Abscesses may go undetected, however, in patients on high- or medium-dose steroid therapy. |
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The final diagnosis was brain abscess in 8 patients, brain tumor in 18 patients, and infarct and hematoma in 1 patient each. Five patients not on corticosteroid treatment showed intense focal 111In accumulation in abscesses, whereas an abscess patient receiving a high steroid dose showed no uptake. Two patients studied twice showed intense uptake in abscesses when not on steroid therapy or on a low dose, whereas no uptake was seen when they received high or medium doses. Weak or moderate 111In uptake was observed in nine tumors. Microscopically assessed degree of tumor granulocyte infiltration, vessel proliferation, and hemorrhage did not correlate with the outcome of 111In GS. Our results suggest that intense focal cerebral 111In uptake favors the abscess diagnosis. Abscesses may go undetected, however, in patients on high- or medium-dose steroid therapy.</description><identifier>ISSN: 0161-5505</identifier><identifier>EISSN: 1535-5667</identifier><identifier>PMID: 2362190</identifier><language>eng</language><publisher>Reston, VA: Soc Nuclear Med</publisher><subject>ABSCESSES ; Adolescent ; Adrenal Cortex Hormones - therapeutic use ; Adult ; Aged ; Aged, 80 and over ; ANIMALS ; BETA DECAY RADIOISOTOPES ; Biological and medical sciences ; BODY ; BRAIN ; Brain Abscess - diagnostic imaging ; Brain Abscess - drug therapy ; Brain Neoplasms - diagnostic imaging ; CENTRAL NERVOUS SYSTEM ; COUNTING TECHNIQUES ; DAYS LIVING RADIOISOTOPES ; DIAGNOSIS ; Diagnosis, Differential ; DIAGNOSTIC TECHNIQUES ; DISEASES ; ELECTRON CAPTURE RADIOISOTOPES ; Female ; Granulocytes ; Humans ; INDIUM 111 ; INDIUM ISOTOPES ; Indium Radioisotopes ; INTERMEDIATE MASS NUCLEI ; Investigative techniques, diagnostic techniques (general aspects) ; ISOMERIC TRANSITION ISOTOPES ; ISOTOPES ; Male ; MAMMALS ; MAN ; Medical sciences ; Middle Aged ; MINUTES LIVING RADIOISOTOPES ; NEOPLASMS ; NERVOUS SYSTEM ; NUCLEI ; ODD-EVEN NUCLEI ; ORGANS ; PATHOLOGICAL CHANGES ; PATIENTS ; PRIMATES ; RADIOISOTOPE SCANNING ; RADIOISOTOPES ; RADIOLOGY AND NUCLEAR MEDICINE ; Radionuclide Imaging ; Radionuclide investigations ; Retrospective Studies ; SCINTISCANNING ; VERTEBRATES 550601 -- Medicine-- Unsealed Radionuclides in Diagnostics</subject><ispartof>The Journal of nuclear medicine (1978), 1990-07, Vol.31 (7), p.1121-1127</ispartof><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,778,782,883</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19416496$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2362190$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/6648647$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Schmidt, Kai G</creatorcontrib><creatorcontrib>Rasmussen, Jens W</creatorcontrib><creatorcontrib>Frederiksen, Povl B</creatorcontrib><creatorcontrib>Kock-Jensen, Carsten</creatorcontrib><creatorcontrib>Pedersen, Niels T</creatorcontrib><title>Indium-111-Granulocyte Scintigraphy in Brain Abscess Diagnosis: Limitations and Pitfalls</title><title>The Journal of nuclear medicine (1978)</title><addtitle>J Nucl Med</addtitle><description>The scintigrams and records of 28 patients referred for indium-111-granulocyte scintigraphy (111In-GS) because of a suspected brain abscess were studied retrospectively. The final diagnosis was brain abscess in 8 patients, brain tumor in 18 patients, and infarct and hematoma in 1 patient each. Five patients not on corticosteroid treatment showed intense focal 111In accumulation in abscesses, whereas an abscess patient receiving a high steroid dose showed no uptake. Two patients studied twice showed intense uptake in abscesses when not on steroid therapy or on a low dose, whereas no uptake was seen when they received high or medium doses. Weak or moderate 111In uptake was observed in nine tumors. Microscopically assessed degree of tumor granulocyte infiltration, vessel proliferation, and hemorrhage did not correlate with the outcome of 111In GS. Our results suggest that intense focal cerebral 111In uptake favors the abscess diagnosis. Abscesses may go undetected, however, in patients on high- or medium-dose steroid therapy.</description><subject>ABSCESSES</subject><subject>Adolescent</subject><subject>Adrenal Cortex Hormones - therapeutic use</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>ANIMALS</subject><subject>BETA DECAY RADIOISOTOPES</subject><subject>Biological and medical sciences</subject><subject>BODY</subject><subject>BRAIN</subject><subject>Brain Abscess - diagnostic imaging</subject><subject>Brain Abscess - drug therapy</subject><subject>Brain Neoplasms - diagnostic imaging</subject><subject>CENTRAL NERVOUS SYSTEM</subject><subject>COUNTING TECHNIQUES</subject><subject>DAYS LIVING RADIOISOTOPES</subject><subject>DIAGNOSIS</subject><subject>Diagnosis, Differential</subject><subject>DIAGNOSTIC TECHNIQUES</subject><subject>DISEASES</subject><subject>ELECTRON CAPTURE RADIOISOTOPES</subject><subject>Female</subject><subject>Granulocytes</subject><subject>Humans</subject><subject>INDIUM 111</subject><subject>INDIUM ISOTOPES</subject><subject>Indium Radioisotopes</subject><subject>INTERMEDIATE MASS NUCLEI</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>ISOMERIC TRANSITION ISOTOPES</subject><subject>ISOTOPES</subject><subject>Male</subject><subject>MAMMALS</subject><subject>MAN</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>MINUTES LIVING RADIOISOTOPES</subject><subject>NEOPLASMS</subject><subject>NERVOUS SYSTEM</subject><subject>NUCLEI</subject><subject>ODD-EVEN NUCLEI</subject><subject>ORGANS</subject><subject>PATHOLOGICAL CHANGES</subject><subject>PATIENTS</subject><subject>PRIMATES</subject><subject>RADIOISOTOPE SCANNING</subject><subject>RADIOISOTOPES</subject><subject>RADIOLOGY AND NUCLEAR MEDICINE</subject><subject>Radionuclide Imaging</subject><subject>Radionuclide investigations</subject><subject>Retrospective Studies</subject><subject>SCINTISCANNING</subject><subject>VERTEBRATES 550601 -- Medicine-- Unsealed Radionuclides in Diagnostics</subject><issn>0161-5505</issn><issn>1535-5667</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kF1LwzAUhoMoc05_glAE9aqQjzZJvdOpczBQUMG7kKbpekabziZF9u-NbHhz3ov34YXzHKEpyVme5pyLYzTFhJM0z3F-is6832CMuZRygiaUcUoKPEVfS1fB2KWEkHQxaDe2vdkFm7wbcAHWg942uwRc8jDoeO9Lb6z3ySPotes9-LtkBR0EHaB3PtGuSt4g1Lpt_Tk6ientxSFn6PP56WP-kq5eF8v5_SptaJGHlDBDC07rHFua2dKWmkrDSmGkwLISEuuSVpiKgtWMGUZLWekqo9xSakRJazZDV_vd3gdQ3kCwpjG9c9YExXkmeSYidLOHtkP_PVofVAfxk7bVzvajV6KQHEdxEbw8gGPZ2UptB-j0sFMHX7G_PvTaG93W0ZgB_4-RIiM8K3jkbvdcA-vmBwar3Ghaq4e_0Y3rGFFCEUIJ-wVpfIFe</recordid><startdate>19900701</startdate><enddate>19900701</enddate><creator>Schmidt, Kai G</creator><creator>Rasmussen, Jens W</creator><creator>Frederiksen, Povl B</creator><creator>Kock-Jensen, Carsten</creator><creator>Pedersen, Niels T</creator><general>Soc Nuclear Med</general><general>Society of Nuclear Medicine</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>19900701</creationdate><title>Indium-111-Granulocyte Scintigraphy in Brain Abscess Diagnosis: Limitations and Pitfalls</title><author>Schmidt, Kai G ; Rasmussen, Jens W ; Frederiksen, Povl B ; Kock-Jensen, Carsten ; Pedersen, Niels T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h295t-13c2962f50e24ebeba28c3b7c8708d780ab2d02793f33c32b8dad426e22c7b2f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>ABSCESSES</topic><topic>Adolescent</topic><topic>Adrenal Cortex Hormones - therapeutic use</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>ANIMALS</topic><topic>BETA DECAY RADIOISOTOPES</topic><topic>Biological and medical sciences</topic><topic>BODY</topic><topic>BRAIN</topic><topic>Brain Abscess - diagnostic imaging</topic><topic>Brain Abscess - drug therapy</topic><topic>Brain Neoplasms - diagnostic imaging</topic><topic>CENTRAL NERVOUS SYSTEM</topic><topic>COUNTING TECHNIQUES</topic><topic>DAYS LIVING RADIOISOTOPES</topic><topic>DIAGNOSIS</topic><topic>Diagnosis, Differential</topic><topic>DIAGNOSTIC TECHNIQUES</topic><topic>DISEASES</topic><topic>ELECTRON CAPTURE RADIOISOTOPES</topic><topic>Female</topic><topic>Granulocytes</topic><topic>Humans</topic><topic>INDIUM 111</topic><topic>INDIUM ISOTOPES</topic><topic>Indium Radioisotopes</topic><topic>INTERMEDIATE MASS NUCLEI</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>ISOMERIC TRANSITION ISOTOPES</topic><topic>ISOTOPES</topic><topic>Male</topic><topic>MAMMALS</topic><topic>MAN</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>MINUTES LIVING RADIOISOTOPES</topic><topic>NEOPLASMS</topic><topic>NERVOUS SYSTEM</topic><topic>NUCLEI</topic><topic>ODD-EVEN NUCLEI</topic><topic>ORGANS</topic><topic>PATHOLOGICAL CHANGES</topic><topic>PATIENTS</topic><topic>PRIMATES</topic><topic>RADIOISOTOPE SCANNING</topic><topic>RADIOISOTOPES</topic><topic>RADIOLOGY AND NUCLEAR MEDICINE</topic><topic>Radionuclide Imaging</topic><topic>Radionuclide investigations</topic><topic>Retrospective Studies</topic><topic>SCINTISCANNING</topic><topic>VERTEBRATES 550601 -- Medicine-- Unsealed Radionuclides in Diagnostics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schmidt, Kai G</creatorcontrib><creatorcontrib>Rasmussen, Jens W</creatorcontrib><creatorcontrib>Frederiksen, Povl B</creatorcontrib><creatorcontrib>Kock-Jensen, Carsten</creatorcontrib><creatorcontrib>Pedersen, Niels T</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>The Journal of nuclear medicine (1978)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schmidt, Kai G</au><au>Rasmussen, Jens W</au><au>Frederiksen, Povl B</au><au>Kock-Jensen, Carsten</au><au>Pedersen, Niels T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Indium-111-Granulocyte Scintigraphy in Brain Abscess Diagnosis: Limitations and Pitfalls</atitle><jtitle>The Journal of nuclear medicine (1978)</jtitle><addtitle>J Nucl Med</addtitle><date>1990-07-01</date><risdate>1990</risdate><volume>31</volume><issue>7</issue><spage>1121</spage><epage>1127</epage><pages>1121-1127</pages><issn>0161-5505</issn><eissn>1535-5667</eissn><abstract>The scintigrams and records of 28 patients referred for indium-111-granulocyte scintigraphy (111In-GS) because of a suspected brain abscess were studied retrospectively. The final diagnosis was brain abscess in 8 patients, brain tumor in 18 patients, and infarct and hematoma in 1 patient each. Five patients not on corticosteroid treatment showed intense focal 111In accumulation in abscesses, whereas an abscess patient receiving a high steroid dose showed no uptake. Two patients studied twice showed intense uptake in abscesses when not on steroid therapy or on a low dose, whereas no uptake was seen when they received high or medium doses. Weak or moderate 111In uptake was observed in nine tumors. Microscopically assessed degree of tumor granulocyte infiltration, vessel proliferation, and hemorrhage did not correlate with the outcome of 111In GS. Our results suggest that intense focal cerebral 111In uptake favors the abscess diagnosis. Abscesses may go undetected, however, in patients on high- or medium-dose steroid therapy.</abstract><cop>Reston, VA</cop><pub>Soc Nuclear Med</pub><pmid>2362190</pmid><tpages>7</tpages></addata></record> |
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| ispartof | The Journal of nuclear medicine (1978), 1990-07, Vol.31 (7), p.1121-1127 |
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| subjects | ABSCESSES Adolescent Adrenal Cortex Hormones - therapeutic use Adult Aged Aged, 80 and over ANIMALS BETA DECAY RADIOISOTOPES Biological and medical sciences BODY BRAIN Brain Abscess - diagnostic imaging Brain Abscess - drug therapy Brain Neoplasms - diagnostic imaging CENTRAL NERVOUS SYSTEM COUNTING TECHNIQUES DAYS LIVING RADIOISOTOPES DIAGNOSIS Diagnosis, Differential DIAGNOSTIC TECHNIQUES DISEASES ELECTRON CAPTURE RADIOISOTOPES Female Granulocytes Humans INDIUM 111 INDIUM ISOTOPES Indium Radioisotopes INTERMEDIATE MASS NUCLEI Investigative techniques, diagnostic techniques (general aspects) ISOMERIC TRANSITION ISOTOPES ISOTOPES Male MAMMALS MAN Medical sciences Middle Aged MINUTES LIVING RADIOISOTOPES NEOPLASMS NERVOUS SYSTEM NUCLEI ODD-EVEN NUCLEI ORGANS PATHOLOGICAL CHANGES PATIENTS PRIMATES RADIOISOTOPE SCANNING RADIOISOTOPES RADIOLOGY AND NUCLEAR MEDICINE Radionuclide Imaging Radionuclide investigations Retrospective Studies SCINTISCANNING VERTEBRATES 550601 -- Medicine-- Unsealed Radionuclides in Diagnostics |
| title | Indium-111-Granulocyte Scintigraphy in Brain Abscess Diagnosis: Limitations and Pitfalls |
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