Comparison of thallium redistribution with rest “reinjection” imaging for the detection of viable myocardium
To determine the incidence of incomplete redistribution on conventional delayed thallium images, 41 patients with persistent perfusion defects on myocardial images recorded 3 to 4 hours after thallium injection during exercise were studied. At the conclusion of their delayed images the patients were...
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| Veröffentlicht in: | The American journal of cardiology 1990-07, Vol.66 (2), p.158-163 |
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| container_title | The American journal of cardiology |
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| creator | Rocco, Thomas P. Dilsizian, Vasken McKusick, Kenneth A. Fischman, Alan J. Boucher, Charles A. Strauss, H.William |
| description | To determine the incidence of incomplete redistribution on conventional delayed thallium images, 41 patients with persistent perfusion defects on myocardial images recorded 3 to 4 hours after thallium injection during exercise were studied. At the conclusion of their delayed images the patients were reinjected at rest with approximately 1 mCi of thallium-201 and a third set of images was recorded. The images were presented at random in pairs (initial:delayed, initial:reinjection) to 2 experienced observers for qualitative scoring of 9 segments/patient. Of the 360 segments analyzed, concordance between the delayed and reinjected images occurred in 307 (85%). Of 141 segments that demonstrated a persistent perfusion abnormality on 3- to 4-hour delayed images, 44 (31%) were reassigned to a redistribution score after reinjection. In 9 patients, reinjection images provided the only evidence of ischemia from the scintigraphic data. In 13 of 14 vascular territories that demonstrated redistribution after reinjection, intact perfusion (either anterograde or via collaterals) was detected at coronary angiography. These data suggest that rest reinjection imaging may provide a means of detecting viable myocardium in segments that demonstrate a fixed perfusion abnormality on conventional 3- to 4-hour delayed thallium images. |
| doi_str_mv | 10.1016/0002-9149(90)90580-T |
| format | Article |
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At the conclusion of their delayed images the patients were reinjected at rest with approximately 1 mCi of thallium-201 and a third set of images was recorded. The images were presented at random in pairs (initial:delayed, initial:reinjection) to 2 experienced observers for qualitative scoring of 9 segments/patient. Of the 360 segments analyzed, concordance between the delayed and reinjected images occurred in 307 (85%). Of 141 segments that demonstrated a persistent perfusion abnormality on 3- to 4-hour delayed images, 44 (31%) were reassigned to a redistribution score after reinjection. In 9 patients, reinjection images provided the only evidence of ischemia from the scintigraphic data. In 13 of 14 vascular territories that demonstrated redistribution after reinjection, intact perfusion (either anterograde or via collaterals) was detected at coronary angiography. These data suggest that rest reinjection imaging may provide a means of detecting viable myocardium in segments that demonstrate a fixed perfusion abnormality on conventional 3- to 4-hour delayed thallium images.</description><identifier>ISSN: 0002-9149</identifier><identifier>EISSN: 1879-1913</identifier><identifier>DOI: 10.1016/0002-9149(90)90580-T</identifier><identifier>PMID: 2371946</identifier><identifier>CODEN: AJCDAG</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Aged ; ANIMALS ; BETA DECAY RADIOISOTOPES ; Biological and medical sciences ; BODY ; Cardiology. Vascular system ; CARDIOVASCULAR DISEASES ; CARDIOVASCULAR SYSTEM ; COMPARATIVE EVALUATIONS ; Coronary Disease - diagnostic imaging ; Coronary Disease - pathology ; Coronary heart disease ; COUNTING TECHNIQUES ; DAYS LIVING RADIOISOTOPES ; DIAGNOSIS ; DIAGNOSTIC TECHNIQUES ; DISEASES ; DISTRIBUTION ; ELECTRON CAPTURE RADIOISOTOPES ; Female ; HEART ; Heart - diagnostic imaging ; HEAVY NUCLEI ; Humans ; Injections, Intravenous ; ISOMERIC TRANSITION ISOTOPES ; ISOTOPES ; Male ; MAMMALS ; MAN ; Medical sciences ; Middle Aged ; MUSCLES ; MYOCARDIAL INFARCTION ; Myocardial Infarction - pathology ; MYOCARDIUM ; Myocardium - pathology ; NUCLEI ; ODD-EVEN NUCLEI ; ORGANS ; PATIENTS ; PERFUSED ORGANS ; PRIMATES ; RADIOISOTOPE SCANNING ; RADIOISOTOPES ; RADIOLOGY AND NUCLEAR MEDICINE ; Radionuclide Imaging ; SCINTISCANNING ; SECONDS LIVING RADIOISOTOPES ; THALLIUM 201 ; THALLIUM ISOTOPES ; Thallium Radioisotopes - administration & dosage ; Thallium Radioisotopes - pharmacokinetics ; TISSUE DISTRIBUTION ; VERTEBRATES 550601 -- Medicine-- Unsealed Radionuclides in Diagnostics</subject><ispartof>The American journal of cardiology, 1990-07, Vol.66 (2), p.158-163</ispartof><rights>1990</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c414t-a7a6a3310821fc6fff4a4c61cc06a0640afb2ecc3a9d65ccb0c6436c20ca05be3</citedby><cites>FETCH-LOGICAL-c414t-a7a6a3310821fc6fff4a4c61cc06a0640afb2ecc3a9d65ccb0c6436c20ca05be3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/000291499090580T$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19547933$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2371946$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/6642636$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Rocco, Thomas P.</creatorcontrib><creatorcontrib>Dilsizian, Vasken</creatorcontrib><creatorcontrib>McKusick, Kenneth A.</creatorcontrib><creatorcontrib>Fischman, Alan J.</creatorcontrib><creatorcontrib>Boucher, Charles A.</creatorcontrib><creatorcontrib>Strauss, H.William</creatorcontrib><title>Comparison of thallium redistribution with rest “reinjection” imaging for the detection of viable myocardium</title><title>The American journal of cardiology</title><addtitle>Am J Cardiol</addtitle><description>To determine the incidence of incomplete redistribution on conventional delayed thallium images, 41 patients with persistent perfusion defects on myocardial images recorded 3 to 4 hours after thallium injection during exercise were studied. At the conclusion of their delayed images the patients were reinjected at rest with approximately 1 mCi of thallium-201 and a third set of images was recorded. The images were presented at random in pairs (initial:delayed, initial:reinjection) to 2 experienced observers for qualitative scoring of 9 segments/patient. Of the 360 segments analyzed, concordance between the delayed and reinjected images occurred in 307 (85%). Of 141 segments that demonstrated a persistent perfusion abnormality on 3- to 4-hour delayed images, 44 (31%) were reassigned to a redistribution score after reinjection. In 9 patients, reinjection images provided the only evidence of ischemia from the scintigraphic data. In 13 of 14 vascular territories that demonstrated redistribution after reinjection, intact perfusion (either anterograde or via collaterals) was detected at coronary angiography. These data suggest that rest reinjection imaging may provide a means of detecting viable myocardium in segments that demonstrate a fixed perfusion abnormality on conventional 3- to 4-hour delayed thallium images.</description><subject>Adult</subject><subject>Aged</subject><subject>ANIMALS</subject><subject>BETA DECAY RADIOISOTOPES</subject><subject>Biological and medical sciences</subject><subject>BODY</subject><subject>Cardiology. Vascular system</subject><subject>CARDIOVASCULAR DISEASES</subject><subject>CARDIOVASCULAR SYSTEM</subject><subject>COMPARATIVE EVALUATIONS</subject><subject>Coronary Disease - diagnostic imaging</subject><subject>Coronary Disease - pathology</subject><subject>Coronary heart disease</subject><subject>COUNTING TECHNIQUES</subject><subject>DAYS LIVING RADIOISOTOPES</subject><subject>DIAGNOSIS</subject><subject>DIAGNOSTIC TECHNIQUES</subject><subject>DISEASES</subject><subject>DISTRIBUTION</subject><subject>ELECTRON CAPTURE RADIOISOTOPES</subject><subject>Female</subject><subject>HEART</subject><subject>Heart - diagnostic imaging</subject><subject>HEAVY NUCLEI</subject><subject>Humans</subject><subject>Injections, Intravenous</subject><subject>ISOMERIC TRANSITION ISOTOPES</subject><subject>ISOTOPES</subject><subject>Male</subject><subject>MAMMALS</subject><subject>MAN</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>MUSCLES</subject><subject>MYOCARDIAL INFARCTION</subject><subject>Myocardial Infarction - pathology</subject><subject>MYOCARDIUM</subject><subject>Myocardium - pathology</subject><subject>NUCLEI</subject><subject>ODD-EVEN NUCLEI</subject><subject>ORGANS</subject><subject>PATIENTS</subject><subject>PERFUSED ORGANS</subject><subject>PRIMATES</subject><subject>RADIOISOTOPE SCANNING</subject><subject>RADIOISOTOPES</subject><subject>RADIOLOGY AND NUCLEAR MEDICINE</subject><subject>Radionuclide Imaging</subject><subject>SCINTISCANNING</subject><subject>SECONDS LIVING RADIOISOTOPES</subject><subject>THALLIUM 201</subject><subject>THALLIUM ISOTOPES</subject><subject>Thallium Radioisotopes - administration & dosage</subject><subject>Thallium Radioisotopes - pharmacokinetics</subject><subject>TISSUE DISTRIBUTION</subject><subject>VERTEBRATES 550601 -- Medicine-- Unsealed Radionuclides in Diagnostics</subject><issn>0002-9149</issn><issn>1879-1913</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcFq3DAURUVoSaZp_yABU0hpF24lS5atTaAMSVsIdDNdi-dnKaNgWxPJTsguH9L-XL6kcj0ku66MfM-7vHsfISeMfmaUyS-U0iJXTKiPin5StKxpvjkgK1ZXKmeK8Vdk9YwckTcx3qQnY6U8JIcFr5gSckV2a9_vILjoh8zbbNxC17mpz4JpXRyDa6bRJenejdv0L47Z0-PvYNxwY3AWnh7_ZK6HazdcZ9aHNG-y1oyLOBveOWg6k_UPHiG0yfkteW2hi-bd_ntMfl1ebNbf86uf336sv17lKJgYc6hAAueM1gWzKK21AgRKhkglUCko2KYwiBxUK0vEhqIUXGJBEWjZGH5M3i--Po5OR3RpqS36YUi7aSlFIblM0IcF2gV_O6V4uncRTdfBYPwUdaXquhaMJVAsIAYfYzBW70LKHR40o3q-hp6r1nPVWlH97xp6k8ZO9_5T05v2eWhff9LP9jpEhM4GGNDFF29VikpxnrjzhTOpsTtnwhzIDJiOFOY8rXf_X-QvU36qiQ</recordid><startdate>19900715</startdate><enddate>19900715</enddate><creator>Rocco, Thomas P.</creator><creator>Dilsizian, Vasken</creator><creator>McKusick, Kenneth A.</creator><creator>Fischman, Alan J.</creator><creator>Boucher, Charles A.</creator><creator>Strauss, H.William</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>19900715</creationdate><title>Comparison of thallium redistribution with rest “reinjection” imaging for the detection of viable myocardium</title><author>Rocco, Thomas P. ; Dilsizian, Vasken ; McKusick, Kenneth A. ; Fischman, Alan J. ; Boucher, Charles A. ; Strauss, H.William</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c414t-a7a6a3310821fc6fff4a4c61cc06a0640afb2ecc3a9d65ccb0c6436c20ca05be3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Adult</topic><topic>Aged</topic><topic>ANIMALS</topic><topic>BETA DECAY RADIOISOTOPES</topic><topic>Biological and medical sciences</topic><topic>BODY</topic><topic>Cardiology. Vascular system</topic><topic>CARDIOVASCULAR DISEASES</topic><topic>CARDIOVASCULAR SYSTEM</topic><topic>COMPARATIVE EVALUATIONS</topic><topic>Coronary Disease - diagnostic imaging</topic><topic>Coronary Disease - pathology</topic><topic>Coronary heart disease</topic><topic>COUNTING TECHNIQUES</topic><topic>DAYS LIVING RADIOISOTOPES</topic><topic>DIAGNOSIS</topic><topic>DIAGNOSTIC TECHNIQUES</topic><topic>DISEASES</topic><topic>DISTRIBUTION</topic><topic>ELECTRON CAPTURE RADIOISOTOPES</topic><topic>Female</topic><topic>HEART</topic><topic>Heart - diagnostic imaging</topic><topic>HEAVY NUCLEI</topic><topic>Humans</topic><topic>Injections, Intravenous</topic><topic>ISOMERIC TRANSITION ISOTOPES</topic><topic>ISOTOPES</topic><topic>Male</topic><topic>MAMMALS</topic><topic>MAN</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>MUSCLES</topic><topic>MYOCARDIAL INFARCTION</topic><topic>Myocardial Infarction - pathology</topic><topic>MYOCARDIUM</topic><topic>Myocardium - pathology</topic><topic>NUCLEI</topic><topic>ODD-EVEN NUCLEI</topic><topic>ORGANS</topic><topic>PATIENTS</topic><topic>PERFUSED ORGANS</topic><topic>PRIMATES</topic><topic>RADIOISOTOPE SCANNING</topic><topic>RADIOISOTOPES</topic><topic>RADIOLOGY AND NUCLEAR MEDICINE</topic><topic>Radionuclide Imaging</topic><topic>SCINTISCANNING</topic><topic>SECONDS LIVING RADIOISOTOPES</topic><topic>THALLIUM 201</topic><topic>THALLIUM ISOTOPES</topic><topic>Thallium Radioisotopes - administration & dosage</topic><topic>Thallium Radioisotopes - pharmacokinetics</topic><topic>TISSUE DISTRIBUTION</topic><topic>VERTEBRATES 550601 -- Medicine-- Unsealed Radionuclides in Diagnostics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rocco, Thomas P.</creatorcontrib><creatorcontrib>Dilsizian, Vasken</creatorcontrib><creatorcontrib>McKusick, Kenneth A.</creatorcontrib><creatorcontrib>Fischman, Alan J.</creatorcontrib><creatorcontrib>Boucher, Charles A.</creatorcontrib><creatorcontrib>Strauss, H.William</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>The American journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rocco, Thomas P.</au><au>Dilsizian, Vasken</au><au>McKusick, Kenneth A.</au><au>Fischman, Alan J.</au><au>Boucher, Charles A.</au><au>Strauss, H.William</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of thallium redistribution with rest “reinjection” imaging for the detection of viable myocardium</atitle><jtitle>The American journal of cardiology</jtitle><addtitle>Am J Cardiol</addtitle><date>1990-07-15</date><risdate>1990</risdate><volume>66</volume><issue>2</issue><spage>158</spage><epage>163</epage><pages>158-163</pages><issn>0002-9149</issn><eissn>1879-1913</eissn><coden>AJCDAG</coden><abstract>To determine the incidence of incomplete redistribution on conventional delayed thallium images, 41 patients with persistent perfusion defects on myocardial images recorded 3 to 4 hours after thallium injection during exercise were studied. At the conclusion of their delayed images the patients were reinjected at rest with approximately 1 mCi of thallium-201 and a third set of images was recorded. The images were presented at random in pairs (initial:delayed, initial:reinjection) to 2 experienced observers for qualitative scoring of 9 segments/patient. Of the 360 segments analyzed, concordance between the delayed and reinjected images occurred in 307 (85%). Of 141 segments that demonstrated a persistent perfusion abnormality on 3- to 4-hour delayed images, 44 (31%) were reassigned to a redistribution score after reinjection. In 9 patients, reinjection images provided the only evidence of ischemia from the scintigraphic data. In 13 of 14 vascular territories that demonstrated redistribution after reinjection, intact perfusion (either anterograde or via collaterals) was detected at coronary angiography. These data suggest that rest reinjection imaging may provide a means of detecting viable myocardium in segments that demonstrate a fixed perfusion abnormality on conventional 3- to 4-hour delayed thallium images.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>2371946</pmid><doi>10.1016/0002-9149(90)90580-T</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-9149 |
| ispartof | The American journal of cardiology, 1990-07, Vol.66 (2), p.158-163 |
| issn | 0002-9149 1879-1913 |
| language | eng |
| recordid | cdi_osti_scitechconnect_6642636 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adult Aged ANIMALS BETA DECAY RADIOISOTOPES Biological and medical sciences BODY Cardiology. Vascular system CARDIOVASCULAR DISEASES CARDIOVASCULAR SYSTEM COMPARATIVE EVALUATIONS Coronary Disease - diagnostic imaging Coronary Disease - pathology Coronary heart disease COUNTING TECHNIQUES DAYS LIVING RADIOISOTOPES DIAGNOSIS DIAGNOSTIC TECHNIQUES DISEASES DISTRIBUTION ELECTRON CAPTURE RADIOISOTOPES Female HEART Heart - diagnostic imaging HEAVY NUCLEI Humans Injections, Intravenous ISOMERIC TRANSITION ISOTOPES ISOTOPES Male MAMMALS MAN Medical sciences Middle Aged MUSCLES MYOCARDIAL INFARCTION Myocardial Infarction - pathology MYOCARDIUM Myocardium - pathology NUCLEI ODD-EVEN NUCLEI ORGANS PATIENTS PERFUSED ORGANS PRIMATES RADIOISOTOPE SCANNING RADIOISOTOPES RADIOLOGY AND NUCLEAR MEDICINE Radionuclide Imaging SCINTISCANNING SECONDS LIVING RADIOISOTOPES THALLIUM 201 THALLIUM ISOTOPES Thallium Radioisotopes - administration & dosage Thallium Radioisotopes - pharmacokinetics TISSUE DISTRIBUTION VERTEBRATES 550601 -- Medicine-- Unsealed Radionuclides in Diagnostics |
| title | Comparison of thallium redistribution with rest “reinjection” imaging for the detection of viable myocardium |
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