Reversibility Bull's-Eye: A New Polar Bull's-Eye Map to Quantify Reversibility of Stress-Induced SPECT Thallium-201 Myocardial Perfusion Defects
Myocardial ischemia is currently interpreted from SPECT thallium-201 (201Tl) tomograms by the subjective visual finding of stress-induced perfusion defects which "normalize" or "reverse" by 4 hr. Thus, we have developed a computer method to quantify and display the three-dimensio...
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| Veröffentlicht in: | The Journal of nuclear medicine (1978) 1990-07, Vol.31 (7), p.1240-1246 |
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| container_title | The Journal of nuclear medicine (1978) |
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| creator | Klein, J. Larry Garcia, Ernest V DePuey, E. Gordon Campbell, Joan Taylor, Andrew T Pettigrew, Roderic I D'Amato, Paul Folks, Russell Alazraki, Naomi |
| description | Myocardial ischemia is currently interpreted from SPECT thallium-201 (201Tl) tomograms by the subjective visual finding of stress-induced perfusion defects which "normalize" or "reverse" by 4 hr. Thus, we have developed a computer method to quantify and display the three-dimensional distribution of reversible segments. Circumferential profiles generated from the short axis slices are normalized to the reference area in the stress study. The stress is subtracted from the normalized delayed data, and then displayed as a polar bull's-eye plot so that positive values show areas that have "reversed" or "improved." Patient profiles are compared to means and standard deviations of reversibility for all pixels determined from the Emory normal male files. Criteria for reversibility were developed from studies of 42 male patients found to have 48 defects, as determined by the consensus of five blinded expert observers. There was computer agreement with the experts on 25 of 31 relatively fixed and 14 of 17 reversible defects. Our preliminary results indicate that this new method promises to aid observers to more consistently identify and quantify the reversibility of SPECT 201Tl myocardial perfusion defects. |
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Larry ; Garcia, Ernest V ; DePuey, E. Gordon ; Campbell, Joan ; Taylor, Andrew T ; Pettigrew, Roderic I ; D'Amato, Paul ; Folks, Russell ; Alazraki, Naomi</creator><creatorcontrib>Klein, J. Larry ; Garcia, Ernest V ; DePuey, E. Gordon ; Campbell, Joan ; Taylor, Andrew T ; Pettigrew, Roderic I ; D'Amato, Paul ; Folks, Russell ; Alazraki, Naomi</creatorcontrib><description>Myocardial ischemia is currently interpreted from SPECT thallium-201 (201Tl) tomograms by the subjective visual finding of stress-induced perfusion defects which "normalize" or "reverse" by 4 hr. Thus, we have developed a computer method to quantify and display the three-dimensional distribution of reversible segments. Circumferential profiles generated from the short axis slices are normalized to the reference area in the stress study. The stress is subtracted from the normalized delayed data, and then displayed as a polar bull's-eye plot so that positive values show areas that have "reversed" or "improved." Patient profiles are compared to means and standard deviations of reversibility for all pixels determined from the Emory normal male files. Criteria for reversibility were developed from studies of 42 male patients found to have 48 defects, as determined by the consensus of five blinded expert observers. There was computer agreement with the experts on 25 of 31 relatively fixed and 14 of 17 reversible defects. Our preliminary results indicate that this new method promises to aid observers to more consistently identify and quantify the reversibility of SPECT 201Tl myocardial perfusion defects.</description><identifier>ISSN: 0161-5505</identifier><identifier>EISSN: 1535-5667</identifier><identifier>PMID: 2362205</identifier><language>eng</language><publisher>Reston, VA: Soc Nuclear Med</publisher><subject>Adult ; ALGORITHMS ; ANIMALS ; ARTERIES ; BETA DECAY RADIOISOTOPES ; Biological and medical sciences ; BLOOD VESSELS ; BODY ; CARDIOVASCULAR DISEASES ; CARDIOVASCULAR SYSTEM ; COMPUTERIZED TOMOGRAPHY ; CORONARIES ; Coronary Circulation ; Coronary Disease - diagnostic imaging ; Coronary Disease - physiopathology ; COUNTING TECHNIQUES ; DAYS LIVING RADIOISOTOPES ; DIAGNOSIS ; Diagnosis, Differential ; DIAGNOSTIC TECHNIQUES ; DISEASES ; ELECTRON CAPTURE RADIOISOTOPES ; EMISSION COMPUTED TOMOGRAPHY ; EXERCISE ; Exercise Test ; HEART ; Heart - diagnostic imaging ; Heart - physiopathology ; HEAVY NUCLEI ; Humans ; Image Processing, Computer-Assisted ; Investigative techniques, diagnostic techniques (general aspects) ; ISCHEMIA ; ISOMERIC TRANSITION ISOTOPES ; ISOTOPES ; Male ; MAMMALS ; MAN ; MATHEMATICAL LOGIC ; Medical sciences ; NUCLEI ; ODD-EVEN NUCLEI ; ORGANS ; PATIENTS ; Pilot Projects ; PRIMATES ; RADIOISOTOPE SCANNING ; RADIOISOTOPES ; RADIOLOGY AND NUCLEAR MEDICINE ; Radionuclide investigations ; Reproducibility of Results ; SCINTISCANNING ; SECONDS LIVING RADIOISOTOPES ; SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY ; THALLIUM 201 ; THALLIUM ISOTOPES ; Thallium Radioisotopes ; TOMOGRAPHY ; Tomography, Emission-Computed, Single-Photon ; VASCULAR DISEASES ; VERTEBRATES 550601 -- Medicine-- Unsealed Radionuclides in Diagnostics</subject><ispartof>The Journal of nuclear medicine (1978), 1990-07, Vol.31 (7), p.1240-1246</ispartof><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19390728$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2362205$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/6609514$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Klein, J. Larry</creatorcontrib><creatorcontrib>Garcia, Ernest V</creatorcontrib><creatorcontrib>DePuey, E. Gordon</creatorcontrib><creatorcontrib>Campbell, Joan</creatorcontrib><creatorcontrib>Taylor, Andrew T</creatorcontrib><creatorcontrib>Pettigrew, Roderic I</creatorcontrib><creatorcontrib>D'Amato, Paul</creatorcontrib><creatorcontrib>Folks, Russell</creatorcontrib><creatorcontrib>Alazraki, Naomi</creatorcontrib><title>Reversibility Bull's-Eye: A New Polar Bull's-Eye Map to Quantify Reversibility of Stress-Induced SPECT Thallium-201 Myocardial Perfusion Defects</title><title>The Journal of nuclear medicine (1978)</title><addtitle>J Nucl Med</addtitle><description>Myocardial ischemia is currently interpreted from SPECT thallium-201 (201Tl) tomograms by the subjective visual finding of stress-induced perfusion defects which "normalize" or "reverse" by 4 hr. Thus, we have developed a computer method to quantify and display the three-dimensional distribution of reversible segments. Circumferential profiles generated from the short axis slices are normalized to the reference area in the stress study. The stress is subtracted from the normalized delayed data, and then displayed as a polar bull's-eye plot so that positive values show areas that have "reversed" or "improved." Patient profiles are compared to means and standard deviations of reversibility for all pixels determined from the Emory normal male files. Criteria for reversibility were developed from studies of 42 male patients found to have 48 defects, as determined by the consensus of five blinded expert observers. There was computer agreement with the experts on 25 of 31 relatively fixed and 14 of 17 reversible defects. Our preliminary results indicate that this new method promises to aid observers to more consistently identify and quantify the reversibility of SPECT 201Tl myocardial perfusion defects.</description><subject>Adult</subject><subject>ALGORITHMS</subject><subject>ANIMALS</subject><subject>ARTERIES</subject><subject>BETA DECAY RADIOISOTOPES</subject><subject>Biological and medical sciences</subject><subject>BLOOD VESSELS</subject><subject>BODY</subject><subject>CARDIOVASCULAR DISEASES</subject><subject>CARDIOVASCULAR SYSTEM</subject><subject>COMPUTERIZED TOMOGRAPHY</subject><subject>CORONARIES</subject><subject>Coronary Circulation</subject><subject>Coronary Disease - diagnostic imaging</subject><subject>Coronary Disease - physiopathology</subject><subject>COUNTING TECHNIQUES</subject><subject>DAYS LIVING RADIOISOTOPES</subject><subject>DIAGNOSIS</subject><subject>Diagnosis, Differential</subject><subject>DIAGNOSTIC TECHNIQUES</subject><subject>DISEASES</subject><subject>ELECTRON CAPTURE RADIOISOTOPES</subject><subject>EMISSION COMPUTED TOMOGRAPHY</subject><subject>EXERCISE</subject><subject>Exercise Test</subject><subject>HEART</subject><subject>Heart - diagnostic imaging</subject><subject>Heart - physiopathology</subject><subject>HEAVY NUCLEI</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>ISCHEMIA</subject><subject>ISOMERIC TRANSITION ISOTOPES</subject><subject>ISOTOPES</subject><subject>Male</subject><subject>MAMMALS</subject><subject>MAN</subject><subject>MATHEMATICAL LOGIC</subject><subject>Medical sciences</subject><subject>NUCLEI</subject><subject>ODD-EVEN NUCLEI</subject><subject>ORGANS</subject><subject>PATIENTS</subject><subject>Pilot Projects</subject><subject>PRIMATES</subject><subject>RADIOISOTOPE SCANNING</subject><subject>RADIOISOTOPES</subject><subject>RADIOLOGY AND NUCLEAR MEDICINE</subject><subject>Radionuclide investigations</subject><subject>Reproducibility of Results</subject><subject>SCINTISCANNING</subject><subject>SECONDS LIVING RADIOISOTOPES</subject><subject>SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY</subject><subject>THALLIUM 201</subject><subject>THALLIUM ISOTOPES</subject><subject>Thallium Radioisotopes</subject><subject>TOMOGRAPHY</subject><subject>Tomography, Emission-Computed, Single-Photon</subject><subject>VASCULAR DISEASES</subject><subject>VERTEBRATES 550601 -- Medicine-- Unsealed Radionuclides in Diagnostics</subject><issn>0161-5505</issn><issn>1535-5667</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpV0F1rFDEUBuBBlLpWf4IQBO3VQD42mYx3dV210Opq1-uQyZw4KZnJNh-W-Rf-ZEd2Eb06cM7Dy-F9VK0IZ7zmQjSPqxUmgtScY_60epbSHcZYSCnPqjPKBKWYr6pf3-AnxOQ6512e0bvi_UWqtzO8RZfoMzygXfA6_rNHN_qAckBfi56yszP6PyBYdJsjpFRfTX0x0KPb3XazR_tBe-_KWFNM0M0cjI690x7tINqSXJjQe7BgcnpePbHaJ3hxmufV9w_b_eZTff3l49Xm8roeKMG5Zp21VErGgEsj7boT0lgpBbSsMW0viBCihzXGsuuBUwuixaYVfYcBuG4ZO69eHXNDyk4l4zKYwYRpWp5QQuCWk_WC3hzRIYb7Aimr0SUD3usJQkmqaSWXS8cLfHmCpRuhV4foRh1ndep5ub8-3XUy2tuoJ-PSX0Za1uKGysVdHN3gfgwPLoKaivGg45_Qu2lkRDWK0DVmvwFY5JSM</recordid><startdate>199007</startdate><enddate>199007</enddate><creator>Klein, J. Larry</creator><creator>Garcia, Ernest V</creator><creator>DePuey, E. Gordon</creator><creator>Campbell, Joan</creator><creator>Taylor, Andrew T</creator><creator>Pettigrew, Roderic I</creator><creator>D'Amato, Paul</creator><creator>Folks, Russell</creator><creator>Alazraki, Naomi</creator><general>Soc Nuclear Med</general><general>Society of Nuclear Medicine</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>199007</creationdate><title>Reversibility Bull's-Eye: A New Polar Bull's-Eye Map to Quantify Reversibility of Stress-Induced SPECT Thallium-201 Myocardial Perfusion Defects</title><author>Klein, J. Larry ; Garcia, Ernest V ; DePuey, E. 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Larry</creatorcontrib><creatorcontrib>Garcia, Ernest V</creatorcontrib><creatorcontrib>DePuey, E. Gordon</creatorcontrib><creatorcontrib>Campbell, Joan</creatorcontrib><creatorcontrib>Taylor, Andrew T</creatorcontrib><creatorcontrib>Pettigrew, Roderic I</creatorcontrib><creatorcontrib>D'Amato, Paul</creatorcontrib><creatorcontrib>Folks, Russell</creatorcontrib><creatorcontrib>Alazraki, Naomi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>The Journal of nuclear medicine (1978)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Klein, J. Larry</au><au>Garcia, Ernest V</au><au>DePuey, E. Gordon</au><au>Campbell, Joan</au><au>Taylor, Andrew T</au><au>Pettigrew, Roderic I</au><au>D'Amato, Paul</au><au>Folks, Russell</au><au>Alazraki, Naomi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reversibility Bull's-Eye: A New Polar Bull's-Eye Map to Quantify Reversibility of Stress-Induced SPECT Thallium-201 Myocardial Perfusion Defects</atitle><jtitle>The Journal of nuclear medicine (1978)</jtitle><addtitle>J Nucl Med</addtitle><date>1990-07</date><risdate>1990</risdate><volume>31</volume><issue>7</issue><spage>1240</spage><epage>1246</epage><pages>1240-1246</pages><issn>0161-5505</issn><eissn>1535-5667</eissn><abstract>Myocardial ischemia is currently interpreted from SPECT thallium-201 (201Tl) tomograms by the subjective visual finding of stress-induced perfusion defects which "normalize" or "reverse" by 4 hr. Thus, we have developed a computer method to quantify and display the three-dimensional distribution of reversible segments. Circumferential profiles generated from the short axis slices are normalized to the reference area in the stress study. The stress is subtracted from the normalized delayed data, and then displayed as a polar bull's-eye plot so that positive values show areas that have "reversed" or "improved." Patient profiles are compared to means and standard deviations of reversibility for all pixels determined from the Emory normal male files. Criteria for reversibility were developed from studies of 42 male patients found to have 48 defects, as determined by the consensus of five blinded expert observers. There was computer agreement with the experts on 25 of 31 relatively fixed and 14 of 17 reversible defects. Our preliminary results indicate that this new method promises to aid observers to more consistently identify and quantify the reversibility of SPECT 201Tl myocardial perfusion defects.</abstract><cop>Reston, VA</cop><pub>Soc Nuclear Med</pub><pmid>2362205</pmid><tpages>7</tpages></addata></record> |
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| ispartof | The Journal of nuclear medicine (1978), 1990-07, Vol.31 (7), p.1240-1246 |
| issn | 0161-5505 1535-5667 |
| language | eng |
| recordid | cdi_osti_scitechconnect_6609514 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adult ALGORITHMS ANIMALS ARTERIES BETA DECAY RADIOISOTOPES Biological and medical sciences BLOOD VESSELS BODY CARDIOVASCULAR DISEASES CARDIOVASCULAR SYSTEM COMPUTERIZED TOMOGRAPHY CORONARIES Coronary Circulation Coronary Disease - diagnostic imaging Coronary Disease - physiopathology COUNTING TECHNIQUES DAYS LIVING RADIOISOTOPES DIAGNOSIS Diagnosis, Differential DIAGNOSTIC TECHNIQUES DISEASES ELECTRON CAPTURE RADIOISOTOPES EMISSION COMPUTED TOMOGRAPHY EXERCISE Exercise Test HEART Heart - diagnostic imaging Heart - physiopathology HEAVY NUCLEI Humans Image Processing, Computer-Assisted Investigative techniques, diagnostic techniques (general aspects) ISCHEMIA ISOMERIC TRANSITION ISOTOPES ISOTOPES Male MAMMALS MAN MATHEMATICAL LOGIC Medical sciences NUCLEI ODD-EVEN NUCLEI ORGANS PATIENTS Pilot Projects PRIMATES RADIOISOTOPE SCANNING RADIOISOTOPES RADIOLOGY AND NUCLEAR MEDICINE Radionuclide investigations Reproducibility of Results SCINTISCANNING SECONDS LIVING RADIOISOTOPES SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY THALLIUM 201 THALLIUM ISOTOPES Thallium Radioisotopes TOMOGRAPHY Tomography, Emission-Computed, Single-Photon VASCULAR DISEASES VERTEBRATES 550601 -- Medicine-- Unsealed Radionuclides in Diagnostics |
| title | Reversibility Bull's-Eye: A New Polar Bull's-Eye Map to Quantify Reversibility of Stress-Induced SPECT Thallium-201 Myocardial Perfusion Defects |
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