Human R1 Subunit of Ribonucleotide Reductase (RRM1): 5′ Flanking Region of the Gene

Ribonucleotide reductase is essential, in dividing cells, for the production of deoxyribonucleotides prior to DNA synthesis in S phase. Neither of its two subunits (R1 and R2) are detectable in quiescent cells. In cycling cells, RRM1 mRNA and R1 protein are present throughout the cell cycle. A fragm...

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