Tissue tolerance of normal and surgically manipulated canine liver to intraoperative radiation therapy (IORT)
Purpose : The purpose of the study is to obtain dose guidelines for the delivery of intraoperative radiotherapy to the liver of patients with colorectal liver metastases. Following partial resection of the liver, a single high dose of 10, 20, 25, and 30 Gy intraoperative radiotherapy was applied to...
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| Veröffentlicht in: | International journal of radiation oncology, biology, physics biology, physics, 1993-12, Vol.27 (5), p.1141-1146 |
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| container_title | International journal of radiation oncology, biology, physics |
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| creator | Cromheecke, Michel Vermeij, Johannes Joris K. Grond, A. Konings, Antonius W.T. Oldhoff, Jan Hoekstra, Harald J. |
| description | Purpose
: The purpose of the study is to obtain dose guidelines for the delivery of intraoperative radiotherapy to the liver of patients with colorectal liver metastases. Following partial resection of the liver, a single high dose of 10, 20, 25, and 30 Gy intraoperative radiotherapy was applied to both the resection plane as well as a nonsurgically manipulated part of the liver of 25 beagles. The temporal sequence of histological and ultrastructural changes of these irradiated parts of the liver tissue was investigated.
Methods and Materials
: The feasibility of delivering single large dose of intraoperative electron beam radiotherapy to the normal and partially hepatectomized liver was experimentally investigated in a canine study.
Results
: There were no postoperative complications, no morbidity or mortality with a minimal follow-up of 1 year. Autopsy performed 3 months following irradiation showed only mild histopathological changes. One year following intraoperative radiotherapy more distinct histopathological changes consisting of capsular thickening, diffuse parenchymal fibrosis and subcapsular hepatocellular atrophy were found. The liver function remained intact.
Conclusion
: This study demonstrated that intraoperative radiotherapy to part of the liver in the canine model can be safely applied and doses up to 30 Gy are well tolerated. |
| doi_str_mv | 10.1016/0360-3016(93)90535-4 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_osti_</sourceid><recordid>TN_cdi_osti_scitechconnect_6568813</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>0360301693905354</els_id><sourcerecordid>76115149</sourcerecordid><originalsourceid>FETCH-LOGICAL-c444t-3d0f8aaeea41485b379c416b9479a5e4d7caf0ccc59d65485dad06aa84be417c3</originalsourceid><addsrcrecordid>eNqFkUuLFDEQgIMo67j6DxSCiOweWpPNo5OLIIuPhYUFGcFbyCTVbqQ7aZP0wvx7084wRz2lqPqqqMqH0EtK3lFC5XvCJOlYiy40u9REMNHxR2hDVa87JsSPx2hzQp6iZ6X8IoRQ2vMzdKau5JVieoOmbShlAVzTCNlGBzgNOKY82RHb6HFZ8s_g7Dju8WRjmJfRVvDYtTgCHsMD5NaLQ6zZprmNqC2Fs_WhRSniet9y8x5f3Nx9214-R08GOxZ4cXzP0ffPn7bXX7vbuy831x9vO8c5rx3zZFDWAlhOuRI71mvHqdxp3msrgPve2YE454T2UjTCW0-ktYrvgNPesXP0-jA3lRpMcaGCu3cpRnDVSCGVoqxBbw_QnNPvBUo1UygOxtFGSEsxvaRUUK7_C1KpuBBKNJAfQJdTKRkGM-cw2bw3lJjVmVmFmFWI0cz8dWZ4a3t1nL_sJvCnpqOkVn9zrNvSVAyrp1BOGFOcUqIa9uGAQfvZhwB5PRyaUh_yerdP4d97_AFK9bN8</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>16845585</pqid></control><display><type>article</type><title>Tissue tolerance of normal and surgically manipulated canine liver to intraoperative radiation therapy (IORT)</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Cromheecke, Michel ; Vermeij, Johannes ; Joris K. Grond, A. ; Konings, Antonius W.T. ; Oldhoff, Jan ; Hoekstra, Harald J.</creator><creatorcontrib>Cromheecke, Michel ; Vermeij, Johannes ; Joris K. Grond, A. ; Konings, Antonius W.T. ; Oldhoff, Jan ; Hoekstra, Harald J.</creatorcontrib><description>Purpose
: The purpose of the study is to obtain dose guidelines for the delivery of intraoperative radiotherapy to the liver of patients with colorectal liver metastases. Following partial resection of the liver, a single high dose of 10, 20, 25, and 30 Gy intraoperative radiotherapy was applied to both the resection plane as well as a nonsurgically manipulated part of the liver of 25 beagles. The temporal sequence of histological and ultrastructural changes of these irradiated parts of the liver tissue was investigated.
Methods and Materials
: The feasibility of delivering single large dose of intraoperative electron beam radiotherapy to the normal and partially hepatectomized liver was experimentally investigated in a canine study.
Results
: There were no postoperative complications, no morbidity or mortality with a minimal follow-up of 1 year. Autopsy performed 3 months following irradiation showed only mild histopathological changes. One year following intraoperative radiotherapy more distinct histopathological changes consisting of capsular thickening, diffuse parenchymal fibrosis and subcapsular hepatocellular atrophy were found. The liver function remained intact.
Conclusion
: This study demonstrated that intraoperative radiotherapy to part of the liver in the canine model can be safely applied and doses up to 30 Gy are well tolerated.</description><identifier>ISSN: 0360-3016</identifier><identifier>EISSN: 1879-355X</identifier><identifier>DOI: 10.1016/0360-3016(93)90535-4</identifier><identifier>PMID: 8262839</identifier><identifier>CODEN: IOBPD3</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>560152 - Radiation Effects on Animals- Animals ; Animals ; Atrophy ; Bile Ducts - pathology ; Bile Ducts - radiation effects ; Biological and medical sciences ; BIOLOGICAL EFFECTS ; BIOLOGICAL MODELS ; BIOLOGICAL RADIATION EFFECTS ; BODY ; Cell Division ; Colorectal Neoplasms - radiotherapy ; DIGESTIVE SYSTEM ; Disease Models, Animal ; Diseases of the digestive system ; Dogs ; GLANDS ; Humans ; Inflammation ; Intraoperative Period ; Intraoperative radiotherapy ; LIVER ; Liver - pathology ; Liver - radiation effects ; Liver - ultrastructure ; Liver Cirrhosis, Experimental - etiology ; Liver Cirrhosis, Experimental - pathology ; Liver Neoplasms - radiotherapy ; Liver Neoplasms - secondary ; Liver Neoplasms - surgery ; Medical sciences ; MEDICINE ; Microscopy, Electron ; Microscopy, Electron, Scanning ; NUCLEAR MEDICINE ; ORGANS ; RADIATION EFFECTS ; RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT ; RADIOLOGY ; RADIOTHERAPY ; Radiotherapy - methods ; Radiotherapy Dosage ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) ; SIDE EFFECTS ; SURGERY ; THERAPY ; Time Factors ; Tissue tolerance</subject><ispartof>International journal of radiation oncology, biology, physics, 1993-12, Vol.27 (5), p.1141-1146</ispartof><rights>1993</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c444t-3d0f8aaeea41485b379c416b9479a5e4d7caf0ccc59d65485dad06aa84be417c3</citedby><cites>FETCH-LOGICAL-c444t-3d0f8aaeea41485b379c416b9479a5e4d7caf0ccc59d65485dad06aa84be417c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0360-3016(93)90535-4$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3841108$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8262839$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/6568813$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Cromheecke, Michel</creatorcontrib><creatorcontrib>Vermeij, Johannes</creatorcontrib><creatorcontrib>Joris K. Grond, A.</creatorcontrib><creatorcontrib>Konings, Antonius W.T.</creatorcontrib><creatorcontrib>Oldhoff, Jan</creatorcontrib><creatorcontrib>Hoekstra, Harald J.</creatorcontrib><title>Tissue tolerance of normal and surgically manipulated canine liver to intraoperative radiation therapy (IORT)</title><title>International journal of radiation oncology, biology, physics</title><addtitle>Int J Radiat Oncol Biol Phys</addtitle><description>Purpose
: The purpose of the study is to obtain dose guidelines for the delivery of intraoperative radiotherapy to the liver of patients with colorectal liver metastases. Following partial resection of the liver, a single high dose of 10, 20, 25, and 30 Gy intraoperative radiotherapy was applied to both the resection plane as well as a nonsurgically manipulated part of the liver of 25 beagles. The temporal sequence of histological and ultrastructural changes of these irradiated parts of the liver tissue was investigated.
Methods and Materials
: The feasibility of delivering single large dose of intraoperative electron beam radiotherapy to the normal and partially hepatectomized liver was experimentally investigated in a canine study.
Results
: There were no postoperative complications, no morbidity or mortality with a minimal follow-up of 1 year. Autopsy performed 3 months following irradiation showed only mild histopathological changes. One year following intraoperative radiotherapy more distinct histopathological changes consisting of capsular thickening, diffuse parenchymal fibrosis and subcapsular hepatocellular atrophy were found. The liver function remained intact.
Conclusion
: This study demonstrated that intraoperative radiotherapy to part of the liver in the canine model can be safely applied and doses up to 30 Gy are well tolerated.</description><subject>560152 - Radiation Effects on Animals- Animals</subject><subject>Animals</subject><subject>Atrophy</subject><subject>Bile Ducts - pathology</subject><subject>Bile Ducts - radiation effects</subject><subject>Biological and medical sciences</subject><subject>BIOLOGICAL EFFECTS</subject><subject>BIOLOGICAL MODELS</subject><subject>BIOLOGICAL RADIATION EFFECTS</subject><subject>BODY</subject><subject>Cell Division</subject><subject>Colorectal Neoplasms - radiotherapy</subject><subject>DIGESTIVE SYSTEM</subject><subject>Disease Models, Animal</subject><subject>Diseases of the digestive system</subject><subject>Dogs</subject><subject>GLANDS</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Intraoperative Period</subject><subject>Intraoperative radiotherapy</subject><subject>LIVER</subject><subject>Liver - pathology</subject><subject>Liver - radiation effects</subject><subject>Liver - ultrastructure</subject><subject>Liver Cirrhosis, Experimental - etiology</subject><subject>Liver Cirrhosis, Experimental - pathology</subject><subject>Liver Neoplasms - radiotherapy</subject><subject>Liver Neoplasms - secondary</subject><subject>Liver Neoplasms - surgery</subject><subject>Medical sciences</subject><subject>MEDICINE</subject><subject>Microscopy, Electron</subject><subject>Microscopy, Electron, Scanning</subject><subject>NUCLEAR MEDICINE</subject><subject>ORGANS</subject><subject>RADIATION EFFECTS</subject><subject>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</subject><subject>RADIOLOGY</subject><subject>RADIOTHERAPY</subject><subject>Radiotherapy - methods</subject><subject>Radiotherapy Dosage</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</subject><subject>SIDE EFFECTS</subject><subject>SURGERY</subject><subject>THERAPY</subject><subject>Time Factors</subject><subject>Tissue tolerance</subject><issn>0360-3016</issn><issn>1879-355X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUuLFDEQgIMo67j6DxSCiOweWpPNo5OLIIuPhYUFGcFbyCTVbqQ7aZP0wvx7084wRz2lqPqqqMqH0EtK3lFC5XvCJOlYiy40u9REMNHxR2hDVa87JsSPx2hzQp6iZ6X8IoRQ2vMzdKau5JVieoOmbShlAVzTCNlGBzgNOKY82RHb6HFZ8s_g7Dju8WRjmJfRVvDYtTgCHsMD5NaLQ6zZprmNqC2Fs_WhRSniet9y8x5f3Nx9214-R08GOxZ4cXzP0ffPn7bXX7vbuy831x9vO8c5rx3zZFDWAlhOuRI71mvHqdxp3msrgPve2YE454T2UjTCW0-ktYrvgNPesXP0-jA3lRpMcaGCu3cpRnDVSCGVoqxBbw_QnNPvBUo1UygOxtFGSEsxvaRUUK7_C1KpuBBKNJAfQJdTKRkGM-cw2bw3lJjVmVmFmFWI0cz8dWZ4a3t1nL_sJvCnpqOkVn9zrNvSVAyrp1BOGFOcUqIa9uGAQfvZhwB5PRyaUh_yerdP4d97_AFK9bN8</recordid><startdate>19931201</startdate><enddate>19931201</enddate><creator>Cromheecke, Michel</creator><creator>Vermeij, Johannes</creator><creator>Joris K. Grond, A.</creator><creator>Konings, Antonius W.T.</creator><creator>Oldhoff, Jan</creator><creator>Hoekstra, Harald J.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>19931201</creationdate><title>Tissue tolerance of normal and surgically manipulated canine liver to intraoperative radiation therapy (IORT)</title><author>Cromheecke, Michel ; Vermeij, Johannes ; Joris K. Grond, A. ; Konings, Antonius W.T. ; Oldhoff, Jan ; Hoekstra, Harald J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c444t-3d0f8aaeea41485b379c416b9479a5e4d7caf0ccc59d65485dad06aa84be417c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>560152 - Radiation Effects on Animals- Animals</topic><topic>Animals</topic><topic>Atrophy</topic><topic>Bile Ducts - pathology</topic><topic>Bile Ducts - radiation effects</topic><topic>Biological and medical sciences</topic><topic>BIOLOGICAL EFFECTS</topic><topic>BIOLOGICAL MODELS</topic><topic>BIOLOGICAL RADIATION EFFECTS</topic><topic>BODY</topic><topic>Cell Division</topic><topic>Colorectal Neoplasms - radiotherapy</topic><topic>DIGESTIVE SYSTEM</topic><topic>Disease Models, Animal</topic><topic>Diseases of the digestive system</topic><topic>Dogs</topic><topic>GLANDS</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Intraoperative Period</topic><topic>Intraoperative radiotherapy</topic><topic>LIVER</topic><topic>Liver - pathology</topic><topic>Liver - radiation effects</topic><topic>Liver - ultrastructure</topic><topic>Liver Cirrhosis, Experimental - etiology</topic><topic>Liver Cirrhosis, Experimental - pathology</topic><topic>Liver Neoplasms - radiotherapy</topic><topic>Liver Neoplasms - secondary</topic><topic>Liver Neoplasms - surgery</topic><topic>Medical sciences</topic><topic>MEDICINE</topic><topic>Microscopy, Electron</topic><topic>Microscopy, Electron, Scanning</topic><topic>NUCLEAR MEDICINE</topic><topic>ORGANS</topic><topic>RADIATION EFFECTS</topic><topic>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</topic><topic>RADIOLOGY</topic><topic>RADIOTHERAPY</topic><topic>Radiotherapy - methods</topic><topic>Radiotherapy Dosage</topic><topic>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</topic><topic>SIDE EFFECTS</topic><topic>SURGERY</topic><topic>THERAPY</topic><topic>Time Factors</topic><topic>Tissue tolerance</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cromheecke, Michel</creatorcontrib><creatorcontrib>Vermeij, Johannes</creatorcontrib><creatorcontrib>Joris K. Grond, A.</creatorcontrib><creatorcontrib>Konings, Antonius W.T.</creatorcontrib><creatorcontrib>Oldhoff, Jan</creatorcontrib><creatorcontrib>Hoekstra, Harald J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>International journal of radiation oncology, biology, physics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cromheecke, Michel</au><au>Vermeij, Johannes</au><au>Joris K. Grond, A.</au><au>Konings, Antonius W.T.</au><au>Oldhoff, Jan</au><au>Hoekstra, Harald J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tissue tolerance of normal and surgically manipulated canine liver to intraoperative radiation therapy (IORT)</atitle><jtitle>International journal of radiation oncology, biology, physics</jtitle><addtitle>Int J Radiat Oncol Biol Phys</addtitle><date>1993-12-01</date><risdate>1993</risdate><volume>27</volume><issue>5</issue><spage>1141</spage><epage>1146</epage><pages>1141-1146</pages><issn>0360-3016</issn><eissn>1879-355X</eissn><coden>IOBPD3</coden><abstract>Purpose
: The purpose of the study is to obtain dose guidelines for the delivery of intraoperative radiotherapy to the liver of patients with colorectal liver metastases. Following partial resection of the liver, a single high dose of 10, 20, 25, and 30 Gy intraoperative radiotherapy was applied to both the resection plane as well as a nonsurgically manipulated part of the liver of 25 beagles. The temporal sequence of histological and ultrastructural changes of these irradiated parts of the liver tissue was investigated.
Methods and Materials
: The feasibility of delivering single large dose of intraoperative electron beam radiotherapy to the normal and partially hepatectomized liver was experimentally investigated in a canine study.
Results
: There were no postoperative complications, no morbidity or mortality with a minimal follow-up of 1 year. Autopsy performed 3 months following irradiation showed only mild histopathological changes. One year following intraoperative radiotherapy more distinct histopathological changes consisting of capsular thickening, diffuse parenchymal fibrosis and subcapsular hepatocellular atrophy were found. The liver function remained intact.
Conclusion
: This study demonstrated that intraoperative radiotherapy to part of the liver in the canine model can be safely applied and doses up to 30 Gy are well tolerated.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>8262839</pmid><doi>10.1016/0360-3016(93)90535-4</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0360-3016 |
| ispartof | International journal of radiation oncology, biology, physics, 1993-12, Vol.27 (5), p.1141-1146 |
| issn | 0360-3016 1879-355X |
| language | eng |
| recordid | cdi_osti_scitechconnect_6568813 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | 560152 - Radiation Effects on Animals- Animals Animals Atrophy Bile Ducts - pathology Bile Ducts - radiation effects Biological and medical sciences BIOLOGICAL EFFECTS BIOLOGICAL MODELS BIOLOGICAL RADIATION EFFECTS BODY Cell Division Colorectal Neoplasms - radiotherapy DIGESTIVE SYSTEM Disease Models, Animal Diseases of the digestive system Dogs GLANDS Humans Inflammation Intraoperative Period Intraoperative radiotherapy LIVER Liver - pathology Liver - radiation effects Liver - ultrastructure Liver Cirrhosis, Experimental - etiology Liver Cirrhosis, Experimental - pathology Liver Neoplasms - radiotherapy Liver Neoplasms - secondary Liver Neoplasms - surgery Medical sciences MEDICINE Microscopy, Electron Microscopy, Electron, Scanning NUCLEAR MEDICINE ORGANS RADIATION EFFECTS RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RADIOLOGY RADIOTHERAPY Radiotherapy - methods Radiotherapy Dosage Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) SIDE EFFECTS SURGERY THERAPY Time Factors Tissue tolerance |
| title | Tissue tolerance of normal and surgically manipulated canine liver to intraoperative radiation therapy (IORT) |
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