Cellular regulation of poly ADP-ribosylation of proteins: II. Augmentation of poly(ADP-ribose) polymerase in SV40 3T3 cells following methotrexate-induced G1/S inhibition of cell cycle progression

SV40-3T3 cells were exposed in monolayer cultures to 5 × 10 −7 M methotrexate (MTX), that inhibited thymidylate synthetase, arrested cell growth without cell killing in 24 h and did not induce single- (ss) or double-strand (ds) breaks in DNA. Following 24, up to 72 h, the poly(ADP-ribose) polymerase...

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Veröffentlicht in:	Experimental cell research 1987-05, Vol.170 (1), p.93-102
Hauptverfasser:	Soóki-Tóth, Agnes, Asghari, Fariba, Kirsten, Eva, Kun, Ernest
Format:	Artikel
Sprache:	eng
Schlagworte:	550201 - Biochemistry- Tracer Techniques 550301 - Cytology- Tracer Techniques 550600 - Medicine 560300 - Chemicals Metabolism & Toxicology AMINO ACIDS ANIMAL CELLS Animals ANTIMETABOLITES BASIC BIOLOGICAL SCIENCES BETA DECAY RADIOISOTOPES BETA-MINUS DECAY RADIOISOTOPES Biological and medical sciences BIOLOGICAL EFFECTS BIOLOGICAL FUNCTIONS CARBOXYLIC ACIDS CELL CYCLE Cell metabolism, cell oxidation Cell physiology Cell Transformation, Viral Cells, Cultured CONNECTIVE TISSUE CELLS DAYS LIVING RADIOISOTOPES DRUGS ELECTROPHORESIS ENZYME INDUCTION ENZYME INHIBITORS ENZYMES EVEN-ODD NUCLEI FIBROBLASTS FUNCTIONS Fundamental and applied biological sciences. Psychology GENE REGULATION HYDROGEN COMPOUNDS Interphase - drug effects ISOTOPE APPLICATIONS ISOTOPES Kinetics LIGHT NUCLEI LIPOTROPIC FACTORS METHIONINE METHOTREXATE Methotrexate - pharmacology Mice Molecular and cellular biology MOLECULAR BIOLOGY NUCLEI NUCLEOTIDYLTRANSFERASES ORGANIC ACIDS ORGANIC COMPOUNDS ORGANIC SULFUR COMPOUNDS PHOSPHORUS-GROUP TRANSFERASES Poly(ADP-ribose) Polymerases - metabolism POLYMERASES POST-TRANSLATION MODIFICATION Proteins - metabolism RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RADIOISOTOPES RADIOLOGY AND NUCLEAR MEDICINE RNA POLYMERASES Simian virus 40 - genetics SOMATIC CELLS STRAND BREAKS SULFUR 35 SULFUR ISOTOPES TRACER TECHNIQUES TRANSFERASES TRITIUM COMPOUNDS
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