Relationship of oxygen dose to angiogenesis induction in irradiated tissue
This study was accomplished in an irradiated rabbit model to assess the angiogenic properties of normobaric oxygen and hyperbaric oxygen as compared with air-breathing controls. Results indicated that normobaric oxygen had no angiogenic properties above normal revascularization of irradiated tissue...
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| Veröffentlicht in: | The American journal of surgery 1990-11, Vol.160 (5), p.519-524 |
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| container_end_page | 524 |
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| container_issue | 5 |
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| container_title | The American journal of surgery |
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| creator | Marx, Robert E. Ehler, William J. Tayapongsak, Pairot Pierce, Leonard W. |
| description | This study was accomplished in an irradiated rabbit model to assess the angiogenic properties of normobaric oxygen and hyperbaric oxygen as compared with air-breathing controls. Results indicated that normobaric oxygen had no angiogenic properties above normal revascularization of irradiated tissue than did air-breathing controls (p=0.89). Hyperbaric oxygen demonstrated an eight- to ninefold increased vascular density over both normobaric oxygen and air-breathing controls (p=0.001). Irradiated tissue develops a hypovacular-hypocellular-hypoxic tissue that does not revascularize spontaneously. Results failed to demonstrate an angiogenic effect of normobaric oxygen. It is suggested that oxygen in this sense is a drug requiring hyperbaric pressures to generate therapeutic effects on chronically hypovascular irradiated tissue. |
| doi_str_mv | 10.1016/S0002-9610(05)81019-0 |
| format | Article |
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Results indicated that normobaric oxygen had no angiogenic properties above normal revascularization of irradiated tissue than did air-breathing controls (p=0.89). Hyperbaric oxygen demonstrated an eight- to ninefold increased vascular density over both normobaric oxygen and air-breathing controls (p=0.001). Irradiated tissue develops a hypovacular-hypocellular-hypoxic tissue that does not revascularize spontaneously. Results failed to demonstrate an angiogenic effect of normobaric oxygen. It is suggested that oxygen in this sense is a drug requiring hyperbaric pressures to generate therapeutic effects on chronically hypovascular irradiated tissue.</description><identifier>ISSN: 0002-9610</identifier><identifier>EISSN: 1879-1883</identifier><identifier>DOI: 10.1016/S0002-9610(05)81019-0</identifier><identifier>PMID: 2240387</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>560152 - Radiation Effects on Animals- Animals ; Air ; ANIMALS ; Atmospheric Pressure ; BIOLOGICAL EFFECTS ; BIOLOGICAL RADIATION EFFECTS ; Collateral Circulation - drug effects ; DOSE-RESPONSE RELATIONSHIPS ; ELEMENTS ; Hyperbaric Oxygenation ; INJURIES ; Male ; MAMMALS ; NONMETALS ; OXYGEN ; Oxygen - administration & dosage ; Oxygen - pharmacology ; RABBITS ; RADIATION EFFECTS ; RADIATION INJURIES ; Radiation Injuries, Experimental - drug therapy ; Radiation Injuries, Experimental - physiopathology ; RADIATION, THERMAL, AND OTHER ENVIRON. 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Results indicated that normobaric oxygen had no angiogenic properties above normal revascularization of irradiated tissue than did air-breathing controls (p=0.89). Hyperbaric oxygen demonstrated an eight- to ninefold increased vascular density over both normobaric oxygen and air-breathing controls (p=0.001). Irradiated tissue develops a hypovacular-hypocellular-hypoxic tissue that does not revascularize spontaneously. Results failed to demonstrate an angiogenic effect of normobaric oxygen. It is suggested that oxygen in this sense is a drug requiring hyperbaric pressures to generate therapeutic effects on chronically hypovascular irradiated tissue.</description><subject>560152 - Radiation Effects on Animals- Animals</subject><subject>Air</subject><subject>ANIMALS</subject><subject>Atmospheric Pressure</subject><subject>BIOLOGICAL EFFECTS</subject><subject>BIOLOGICAL RADIATION EFFECTS</subject><subject>Collateral Circulation - drug effects</subject><subject>DOSE-RESPONSE RELATIONSHIPS</subject><subject>ELEMENTS</subject><subject>Hyperbaric Oxygenation</subject><subject>INJURIES</subject><subject>Male</subject><subject>MAMMALS</subject><subject>NONMETALS</subject><subject>OXYGEN</subject><subject>Oxygen - administration & dosage</subject><subject>Oxygen - pharmacology</subject><subject>RABBITS</subject><subject>RADIATION EFFECTS</subject><subject>RADIATION INJURIES</subject><subject>Radiation Injuries, Experimental - drug therapy</subject><subject>Radiation Injuries, Experimental - physiopathology</subject><subject>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. 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POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. 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Results indicated that normobaric oxygen had no angiogenic properties above normal revascularization of irradiated tissue than did air-breathing controls (p=0.89). Hyperbaric oxygen demonstrated an eight- to ninefold increased vascular density over both normobaric oxygen and air-breathing controls (p=0.001). Irradiated tissue develops a hypovacular-hypocellular-hypoxic tissue that does not revascularize spontaneously. Results failed to demonstrate an angiogenic effect of normobaric oxygen. It is suggested that oxygen in this sense is a drug requiring hyperbaric pressures to generate therapeutic effects on chronically hypovascular irradiated tissue.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>2240387</pmid><doi>10.1016/S0002-9610(05)81019-0</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-9610 |
| ispartof | The American journal of surgery, 1990-11, Vol.160 (5), p.519-524 |
| issn | 0002-9610 1879-1883 |
| language | eng |
| recordid | cdi_osti_scitechconnect_6270679 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | 560152 - Radiation Effects on Animals- Animals Air ANIMALS Atmospheric Pressure BIOLOGICAL EFFECTS BIOLOGICAL RADIATION EFFECTS Collateral Circulation - drug effects DOSE-RESPONSE RELATIONSHIPS ELEMENTS Hyperbaric Oxygenation INJURIES Male MAMMALS NONMETALS OXYGEN Oxygen - administration & dosage Oxygen - pharmacology RABBITS RADIATION EFFECTS RADIATION INJURIES Radiation Injuries, Experimental - drug therapy Radiation Injuries, Experimental - physiopathology RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RADIOSENSITIVITY EFFECTS VERTEBRATES |
| title | Relationship of oxygen dose to angiogenesis induction in irradiated tissue |
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