Tumor Cell Growth Arrest Caused by Subchromosomal Transferable DNA Fragments from Chromosome 11

A fundamental problem in the identification and isolation of tumor suppressor and other growth-inhibiting genes is the loss of power of genetic complementation at the subchromosomal level. A direct genetic strategy was developed to isolate subchromosomal transferable fragments (STFs) from any chromo...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1993-04, Vol.260 (5106), p.361-364
Hauptverfasser:	Koi, Minoru, Johnson, Laura A., Kalikin, Linda M., Peter F. R. Little, Nakamura, Yusuke, Feinberg, Andrew P.
Format:	Artikel
Sprache:	eng
Schlagworte:	550400 - Genetics ANIMAL CELLS Animals Base Sequence BASIC BIOLOGICAL SCIENCES Biological and medical sciences Cell Division Cell fusion Cell growth Cell Line Cell lines cell proliferation CHO Cells CHROMOSOMAL ABERRATIONS chromosome 1 CHROMOSOMES Chromosomes, Human, Pair 11 CLONING Cricetinae DISEASES Diseases of striated muscles. Neuromuscular diseases DNA DNA - genetics DNA HYBRIDIZATION DNA-CLONING gene transfer GENES Genes, Tumor Suppressor Genetic Markers Genetic Techniques Globins - genetics GROWTH HUMAN CHROMOSOMES Humans Hybridity HYBRIDIZATION INHIBITION Insulin - genetics man MAPPING Medical sciences Mice Molecular Sequence Data MUTATIONS NEOPLASMS Neurology Polymerase chain reaction Rhabdomyosarcoma - pathology Transfection Tumor Cells, Cultured Tumor suppressor genes Tumors tumours
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