Recognition of Distinctive Patterns of Gallium-67 Distribution in Sarcoidosis
Assessment of gallium-67 (67Ga) uptake in the salivary and lacrimal glands and intrathoracic lymph nodes was made in 605 consecutive patients including 65 with sarcoidosis. A distinctive intrathoracic lymph node 67Ga uptake pattern, resembling the Greek letter lambda, was observed only in sarcoidosi...
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| Veröffentlicht in: | The Journal of nuclear medicine (1978) 1990-12, Vol.31 (12), p.1909-1914 |
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| container_issue | 12 |
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| container_title | The Journal of nuclear medicine (1978) |
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| creator | Sulavik, Stephen B Spencer, Richard P Weed, David A Shapiro, Howard R Shiue, Shyi-Tang Castriotta, Richard J |
| description | Assessment of gallium-67 (67Ga) uptake in the salivary and lacrimal glands and intrathoracic lymph nodes was made in 605 consecutive patients including 65 with sarcoidosis. A distinctive intrathoracic lymph node 67Ga uptake pattern, resembling the Greek letter lambda, was observed only in sarcoidosis (72%). Symmetrical lacrimal gland and parotid gland 67Ga uptake (panda appearance) was noted in 79% of sarcoidosis patients. A simultaneous lambda and panda pattern (62%) or a panda appearance with radiographic bilateral, symmetrical, hilar lymphadenopathy (6%) was present only in sarcoidosis patients. The presence of either of these patterns was particularly prevalent in roentgen Stages I (80%) or II (74%). We conclude that simultaneous (a) lambda and panda images, or (b) a panda image with bilateral symmetrical hilar lymphadenopathy on chest X-ray represent distinctive patterns which are highly specific for sarcoidosis, and may obviate the need for invasive diagnostic procedures. |
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A distinctive intrathoracic lymph node 67Ga uptake pattern, resembling the Greek letter lambda, was observed only in sarcoidosis (72%). Symmetrical lacrimal gland and parotid gland 67Ga uptake (panda appearance) was noted in 79% of sarcoidosis patients. A simultaneous lambda and panda pattern (62%) or a panda appearance with radiographic bilateral, symmetrical, hilar lymphadenopathy (6%) was present only in sarcoidosis patients. The presence of either of these patterns was particularly prevalent in roentgen Stages I (80%) or II (74%). We conclude that simultaneous (a) lambda and panda images, or (b) a panda image with bilateral symmetrical hilar lymphadenopathy on chest X-ray represent distinctive patterns which are highly specific for sarcoidosis, and may obviate the need for invasive diagnostic procedures.</description><identifier>ISSN: 0161-5505</identifier><identifier>EISSN: 1535-5667</identifier><identifier>PMID: 2266386</identifier><language>eng</language><publisher>Reston, VA: Soc Nuclear Med</publisher><subject>560161 - Radionuclide Effects, Kinetics, & Toxicology- Man ; BETA DECAY RADIOISOTOPES ; Biological and medical sciences ; BODY ; DAYS LIVING RADIOISOTOPES ; DISEASES ; ELECTRON CAPTURE RADIOISOTOPES ; GALLIUM 67 ; GALLIUM ISOTOPES ; Gallium Radioisotopes - pharmacokinetics ; GLANDS ; Humans ; INTERMEDIATE MASS NUCLEI ; Investigative techniques, diagnostic techniques (general aspects) ; ISOTOPES ; Lacrimal Apparatus - metabolism ; Lung ; LYMPH NODES ; Lymph Nodes - metabolism ; LYMPHATIC SYSTEM ; Mediastinum ; Medical sciences ; NERVOUS SYSTEM DISEASES ; NUCLEI ; ODD-EVEN NUCLEI ; ORGANS ; PATIENTS ; RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. 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A distinctive intrathoracic lymph node 67Ga uptake pattern, resembling the Greek letter lambda, was observed only in sarcoidosis (72%). Symmetrical lacrimal gland and parotid gland 67Ga uptake (panda appearance) was noted in 79% of sarcoidosis patients. A simultaneous lambda and panda pattern (62%) or a panda appearance with radiographic bilateral, symmetrical, hilar lymphadenopathy (6%) was present only in sarcoidosis patients. The presence of either of these patterns was particularly prevalent in roentgen Stages I (80%) or II (74%). We conclude that simultaneous (a) lambda and panda images, or (b) a panda image with bilateral symmetrical hilar lymphadenopathy on chest X-ray represent distinctive patterns which are highly specific for sarcoidosis, and may obviate the need for invasive diagnostic procedures.</description><subject>560161 - Radionuclide Effects, Kinetics, & Toxicology- Man</subject><subject>BETA DECAY RADIOISOTOPES</subject><subject>Biological and medical sciences</subject><subject>BODY</subject><subject>DAYS LIVING RADIOISOTOPES</subject><subject>DISEASES</subject><subject>ELECTRON CAPTURE RADIOISOTOPES</subject><subject>GALLIUM 67</subject><subject>GALLIUM ISOTOPES</subject><subject>Gallium Radioisotopes - pharmacokinetics</subject><subject>GLANDS</subject><subject>Humans</subject><subject>INTERMEDIATE MASS NUCLEI</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>ISOTOPES</subject><subject>Lacrimal Apparatus - metabolism</subject><subject>Lung</subject><subject>LYMPH NODES</subject><subject>Lymph Nodes - metabolism</subject><subject>LYMPHATIC SYSTEM</subject><subject>Mediastinum</subject><subject>Medical sciences</subject><subject>NERVOUS SYSTEM DISEASES</subject><subject>NUCLEI</subject><subject>ODD-EVEN NUCLEI</subject><subject>ORGANS</subject><subject>PATIENTS</subject><subject>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</subject><subject>RADIOISOTOPES</subject><subject>Radionuclide Imaging</subject><subject>RADIONUCLIDE KINETICS</subject><subject>SALIVARY GLANDS</subject><subject>Salivary Glands - metabolism</subject><subject>Sarcoidosis - diagnostic imaging</subject><subject>Sarcoidosis - metabolism</subject><subject>UPTAKE</subject><issn>0161-5505</issn><issn>1535-5667</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo90NtKAzEQBuBFlFqrjyAsIuLNQs6HS6lahYri4TqkabZN2U1qklV8e7d28Wpg5pufYQ6KMaSYVpQxfliMAWSwohTQ4-IkpQ0AgAkhRsUIIcawYOPi6dWasPIuu-DLUJe3LmXnTXZftnzROdvo064_003jurZi_I9Et-j-Vpwv33Q0wS1Dcum0OKp1k-zZUCfFx_3d-_Shmj_PHqc382qNIMgVxJJDSaSEVgDMl4JzAgiVRi40psjUGNUWCsIg4QBZvNAIAAEgJ1gDUUM8KS72uaG_ViXjsjVrE7y3JiuGgGCC9Ohqj7YxfHY2ZdW6ZGzTaG9Dl1QfKAlntIfnA-wWrV2qbXStjj9qeFI_vxzmOhnd1FF749I_owRCLGTPrvds7Vbrbxet8p1prI67zI1vMVQQKSiBxL8cX3vg</recordid><startdate>199012</startdate><enddate>199012</enddate><creator>Sulavik, Stephen B</creator><creator>Spencer, Richard P</creator><creator>Weed, David A</creator><creator>Shapiro, Howard R</creator><creator>Shiue, Shyi-Tang</creator><creator>Castriotta, Richard J</creator><general>Soc Nuclear Med</general><general>Society of Nuclear Medicine</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>199012</creationdate><title>Recognition of Distinctive Patterns of Gallium-67 Distribution in Sarcoidosis</title><author>Sulavik, Stephen B ; Spencer, Richard P ; Weed, David A ; Shapiro, Howard R ; Shiue, Shyi-Tang ; Castriotta, Richard J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h210t-1397194991e8037d87740459c9ba352cf32fe184614702e3ba200801743a08f13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>560161 - Radionuclide Effects, Kinetics, & Toxicology- Man</topic><topic>BETA DECAY RADIOISOTOPES</topic><topic>Biological and medical sciences</topic><topic>BODY</topic><topic>DAYS LIVING RADIOISOTOPES</topic><topic>DISEASES</topic><topic>ELECTRON CAPTURE RADIOISOTOPES</topic><topic>GALLIUM 67</topic><topic>GALLIUM ISOTOPES</topic><topic>Gallium Radioisotopes - pharmacokinetics</topic><topic>GLANDS</topic><topic>Humans</topic><topic>INTERMEDIATE MASS NUCLEI</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>ISOTOPES</topic><topic>Lacrimal Apparatus - metabolism</topic><topic>Lung</topic><topic>LYMPH NODES</topic><topic>Lymph Nodes - metabolism</topic><topic>LYMPHATIC SYSTEM</topic><topic>Mediastinum</topic><topic>Medical sciences</topic><topic>NERVOUS SYSTEM DISEASES</topic><topic>NUCLEI</topic><topic>ODD-EVEN NUCLEI</topic><topic>ORGANS</topic><topic>PATIENTS</topic><topic>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</topic><topic>RADIOISOTOPES</topic><topic>Radionuclide Imaging</topic><topic>RADIONUCLIDE KINETICS</topic><topic>SALIVARY GLANDS</topic><topic>Salivary Glands - metabolism</topic><topic>Sarcoidosis - diagnostic imaging</topic><topic>Sarcoidosis - metabolism</topic><topic>UPTAKE</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sulavik, Stephen B</creatorcontrib><creatorcontrib>Spencer, Richard P</creatorcontrib><creatorcontrib>Weed, David A</creatorcontrib><creatorcontrib>Shapiro, Howard R</creatorcontrib><creatorcontrib>Shiue, Shyi-Tang</creatorcontrib><creatorcontrib>Castriotta, Richard J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>The Journal of nuclear medicine (1978)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sulavik, Stephen B</au><au>Spencer, Richard P</au><au>Weed, David A</au><au>Shapiro, Howard R</au><au>Shiue, Shyi-Tang</au><au>Castriotta, Richard J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Recognition of Distinctive Patterns of Gallium-67 Distribution in Sarcoidosis</atitle><jtitle>The Journal of nuclear medicine (1978)</jtitle><addtitle>J Nucl Med</addtitle><date>1990-12</date><risdate>1990</risdate><volume>31</volume><issue>12</issue><spage>1909</spage><epage>1914</epage><pages>1909-1914</pages><issn>0161-5505</issn><eissn>1535-5667</eissn><abstract>Assessment of gallium-67 (67Ga) uptake in the salivary and lacrimal glands and intrathoracic lymph nodes was made in 605 consecutive patients including 65 with sarcoidosis. A distinctive intrathoracic lymph node 67Ga uptake pattern, resembling the Greek letter lambda, was observed only in sarcoidosis (72%). Symmetrical lacrimal gland and parotid gland 67Ga uptake (panda appearance) was noted in 79% of sarcoidosis patients. A simultaneous lambda and panda pattern (62%) or a panda appearance with radiographic bilateral, symmetrical, hilar lymphadenopathy (6%) was present only in sarcoidosis patients. The presence of either of these patterns was particularly prevalent in roentgen Stages I (80%) or II (74%). We conclude that simultaneous (a) lambda and panda images, or (b) a panda image with bilateral symmetrical hilar lymphadenopathy on chest X-ray represent distinctive patterns which are highly specific for sarcoidosis, and may obviate the need for invasive diagnostic procedures.</abstract><cop>Reston, VA</cop><pub>Soc Nuclear Med</pub><pmid>2266386</pmid><tpages>6</tpages></addata></record> |
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| subjects | 560161 - Radionuclide Effects, Kinetics, & Toxicology- Man BETA DECAY RADIOISOTOPES Biological and medical sciences BODY DAYS LIVING RADIOISOTOPES DISEASES ELECTRON CAPTURE RADIOISOTOPES GALLIUM 67 GALLIUM ISOTOPES Gallium Radioisotopes - pharmacokinetics GLANDS Humans INTERMEDIATE MASS NUCLEI Investigative techniques, diagnostic techniques (general aspects) ISOTOPES Lacrimal Apparatus - metabolism Lung LYMPH NODES Lymph Nodes - metabolism LYMPHATIC SYSTEM Mediastinum Medical sciences NERVOUS SYSTEM DISEASES NUCLEI ODD-EVEN NUCLEI ORGANS PATIENTS RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RADIOISOTOPES Radionuclide Imaging RADIONUCLIDE KINETICS SALIVARY GLANDS Salivary Glands - metabolism Sarcoidosis - diagnostic imaging Sarcoidosis - metabolism UPTAKE |
| title | Recognition of Distinctive Patterns of Gallium-67 Distribution in Sarcoidosis |
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