Reductions in Calcium Uptake Induced in Rat Brain Synaptosomes by Ionizing Radiation

Gamma irradiation (60 Co) reduced KCl-stimulated voltage-dependent 45 Ca2+ uptake in whole-brain, cortical, and striatal synaptosomes. The time course (3, 10, 30, and 60 s) of calcium uptake by irradiated (3 Gy) and nonirradiated synaptosomes, as well as the effect of KCl (15-65 mM), was measured in...

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Veröffentlicht in:	Radiation research 1991-02, Vol.125 (2), p.158-162
Hauptverfasser:	Kandasamy, Sathasiva B., Howerton, Thomas C., Hunt, Walter A.
Format:	Artikel
Sprache:	eng
Schlagworte:	560152 - Radiation Effects on Animals- Animals ALKALINE EARTH ISOTOPES ALKALINE EARTH METAL COMPOUNDS ANIMAL CELLS ANIMALS BETA DECAY RADIOISOTOPES BETA-MINUS DECAY RADIOISOTOPES Biological and medical sciences BIOLOGICAL EFFECTS BIOLOGICAL RADIATION EFFECTS BODY BRAIN Brain - cytology Calcium Calcium - pharmacokinetics CALCIUM 45 Calcium channels CALCIUM COMPOUNDS CALCIUM ISOTOPES CENTRAL NERVOUS SYSTEM Cerebral Cortex - cytology COBALT 60 COBALT ISOTOPES Cobalt Radioisotopes Corpus Striatum - cytology DAYS LIVING RADIOISOTOPES Dihydropyridines Dosimetry ELECTROMAGNETIC RADIATION EVEN-ODD NUCLEI GAMMA RADIATION In Vitro Techniques INTERMEDIATE MASS NUCLEI INTERNAL CONVERSION RADIOISOTOPES Ionizing radiation IONIZING RADIATIONS Irradiation ISOMERIC TRANSITION ISOTOPES ISOTOPES Male MAMMALS Medical sciences MINUTES LIVING RADIOISOTOPES NERVE CELLS NERVOUS SYSTEM NUCLEI ODD-ODD NUCLEI ORGANS Potassium Chloride - pharmacology Radiation dosage RADIATION EFFECTS RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RADIATIONS RADIOISOTOPES Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) RATS Rats, Inbred Strains Receptors RODENTS SOMATIC CELLS Space life sciences Stimulation, Chemical Synaptosomes Synaptosomes - drug effects Synaptosomes - metabolism Synaptosomes - radiation effects Time Factors UPTAKE VERTEBRATES YEARS LIVING RADIOISOT
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