Influence of alkyl chain length on the stability of n-alkyl-modified reversed phases. 2. Model dissolution study
A direct, in situ study of the hydrolysis and dissolution of various n-alkyl modified phases was performed with {sup 29}Si magic angle spinning NMR spectrometry as a model for stationary phase aging in laboratory practice. With this study, the substantial effect of the ligand length on the dissoluti...
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| Veröffentlicht in: | Analytical chemistry (Washington) 1990-11, Vol.62 (21), p.2296-2300 |
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| container_title | Analytical chemistry (Washington) |
| container_volume | 62 |
| creator | Hetem, Martin J. J De Haan, Jan W Claessens, Henk A Van de Ven, Leo J. M Cramers, Carel A Wijnen, Peter W. J. G Kinkel, Joachim N |
| description | A direct, in situ study of the hydrolysis and dissolution of various n-alkyl modified phases was performed with {sup 29}Si magic angle spinning NMR spectrometry as a model for stationary phase aging in laboratory practice. With this study, the substantial effect of the ligand length on the dissolution reaction of the alkyl modified phases under aggressive eluent conditions is confirmed. As expected, longer n-alkyl ligands gradually show better substrate shielding properties. Above a certain critical ligand length, shielding by longer ligands inhibit the dissolution rate drastically by affecting the hydrolysis and dissolution processes. The type of solvent system used, in liquid chromatography practice or for dissolution studies as reported here, mainly affects the proportions of dissolved silicates in the eluent. On the basis of this in situ dissolution study a model for ligand and substrate hydrolysis and dissolution with the involved reactions is presented. |
| doi_str_mv | 10.1021/ac00220a008 |
| format | Article |
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Model dissolution study</title><source>American Chemical Society Journals</source><creator>Hetem, Martin J. J ; De Haan, Jan W ; Claessens, Henk A ; Van de Ven, Leo J. M ; Cramers, Carel A ; Wijnen, Peter W. J. G ; Kinkel, Joachim N</creator><creatorcontrib>Hetem, Martin J. J ; De Haan, Jan W ; Claessens, Henk A ; Van de Ven, Leo J. M ; Cramers, Carel A ; Wijnen, Peter W. J. G ; Kinkel, Joachim N</creatorcontrib><description>A direct, in situ study of the hydrolysis and dissolution of various n-alkyl modified phases was performed with {sup 29}Si magic angle spinning NMR spectrometry as a model for stationary phase aging in laboratory practice. With this study, the substantial effect of the ligand length on the dissolution reaction of the alkyl modified phases under aggressive eluent conditions is confirmed. As expected, longer n-alkyl ligands gradually show better substrate shielding properties. Above a certain critical ligand length, shielding by longer ligands inhibit the dissolution rate drastically by affecting the hydrolysis and dissolution processes. The type of solvent system used, in liquid chromatography practice or for dissolution studies as reported here, mainly affects the proportions of dissolved silicates in the eluent. On the basis of this in situ dissolution study a model for ligand and substrate hydrolysis and dissolution with the involved reactions is presented.</description><identifier>ISSN: 0003-2700</identifier><identifier>EISSN: 1520-6882</identifier><identifier>DOI: 10.1021/ac00220a008</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><subject>400102 - Chemical & Spectral Procedures ; CALCULATION METHODS ; CHROMATOGRAPHY ; COLUMN PACKING ; EVEN-ODD NUCLEI ; EXTRACTION APPARATUSES ; EXTRACTION COLUMNS ; INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY ; ISOTOPES ; LIGHT NUCLEI ; LIQUID COLUMN CHROMATOGRAPHY ; MAGNETIC RESONANCE ; NUCLEAR MAGNETIC RESONANCE ; NUCLEI ; PACKINGS ; RESONANCE ; SEPARATION EQUIPMENT ; SEPARATION PROCESSES ; SILICON 29 ; SILICON ISOTOPES ; STABILITY ; STABLE ISOTOPES</subject><ispartof>Analytical chemistry (Washington), 1990-11, Vol.62 (21), p.2296-2300</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a3168-dcf898f4ab68014918634480757dab5d97717d837a039fc9444fd5fac0b696013</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/ac00220a008$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/ac00220a008$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>230,314,780,784,885,2765,27076,27924,27925,56738,56788</link.rule.ids><backlink>$$Uhttps://www.osti.gov/biblio/6105423$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Hetem, Martin J. 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As expected, longer n-alkyl ligands gradually show better substrate shielding properties. Above a certain critical ligand length, shielding by longer ligands inhibit the dissolution rate drastically by affecting the hydrolysis and dissolution processes. The type of solvent system used, in liquid chromatography practice or for dissolution studies as reported here, mainly affects the proportions of dissolved silicates in the eluent. On the basis of this in situ dissolution study a model for ligand and substrate hydrolysis and dissolution with the involved reactions is presented.</description><subject>400102 - Chemical & Spectral Procedures</subject><subject>CALCULATION METHODS</subject><subject>CHROMATOGRAPHY</subject><subject>COLUMN PACKING</subject><subject>EVEN-ODD NUCLEI</subject><subject>EXTRACTION APPARATUSES</subject><subject>EXTRACTION COLUMNS</subject><subject>INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY</subject><subject>ISOTOPES</subject><subject>LIGHT NUCLEI</subject><subject>LIQUID COLUMN CHROMATOGRAPHY</subject><subject>MAGNETIC RESONANCE</subject><subject>NUCLEAR MAGNETIC RESONANCE</subject><subject>NUCLEI</subject><subject>PACKINGS</subject><subject>RESONANCE</subject><subject>SEPARATION EQUIPMENT</subject><subject>SEPARATION PROCESSES</subject><subject>SILICON 29</subject><subject>SILICON ISOTOPES</subject><subject>STABILITY</subject><subject>STABLE ISOTOPES</subject><issn>0003-2700</issn><issn>1520-6882</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><recordid>eNpt0EtLAzEUBeAgCtbHyj8Q3LiQqTfzSDJLqdYW6gPUjZuQ5uFEp0mZpGL_vVMr4sLVvYuPA-cgdEJgSCAnF1IB5DlIAL6DBqTKIaOc57toAABFljOAfXQQ4xsAIUDoAC2n3rYr45XBwWLZvq9brBrpPG6Nf00NDh6nxuCY5Ny1Lq03zGffMFsE7awzGnfmw3Sxf5aNjCYOcT7Et0GbFmsXY2hXyfU5Ma30-gjtWdlGc_xzD9Hz-PppNMlm9zfT0eUskwWhPNPK8prbUs4pB1LWhNOiLDmwimk5r3TNGGGaF0xCUVtVl2VpdWX7Aea0pkCKQ3S6zQ0xORGVS0Y1KnhvVBKUQFXmRY_Ot0h1IcbOWLHs3EJ2a0FAbBYVfxbtdbbVLibz-Utl9y4oK1glnh4exdXsZcwm9E5UvT_beqmieAurzveF_03-AofIg4w</recordid><startdate>19901101</startdate><enddate>19901101</enddate><creator>Hetem, Martin J. 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J</creatorcontrib><creatorcontrib>De Haan, Jan W</creatorcontrib><creatorcontrib>Claessens, Henk A</creatorcontrib><creatorcontrib>Van de Ven, Leo J. M</creatorcontrib><creatorcontrib>Cramers, Carel A</creatorcontrib><creatorcontrib>Wijnen, Peter W. J. G</creatorcontrib><creatorcontrib>Kinkel, Joachim N</creatorcontrib><collection>Istex</collection><collection>CrossRef</collection><collection>OSTI.GOV</collection><jtitle>Analytical chemistry (Washington)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hetem, Martin J. J</au><au>De Haan, Jan W</au><au>Claessens, Henk A</au><au>Van de Ven, Leo J. M</au><au>Cramers, Carel A</au><au>Wijnen, Peter W. J. G</au><au>Kinkel, Joachim N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of alkyl chain length on the stability of n-alkyl-modified reversed phases. 2. Model dissolution study</atitle><jtitle>Analytical chemistry (Washington)</jtitle><addtitle>Anal. Chem</addtitle><date>1990-11-01</date><risdate>1990</risdate><volume>62</volume><issue>21</issue><spage>2296</spage><epage>2300</epage><pages>2296-2300</pages><issn>0003-2700</issn><eissn>1520-6882</eissn><abstract>A direct, in situ study of the hydrolysis and dissolution of various n-alkyl modified phases was performed with {sup 29}Si magic angle spinning NMR spectrometry as a model for stationary phase aging in laboratory practice. With this study, the substantial effect of the ligand length on the dissolution reaction of the alkyl modified phases under aggressive eluent conditions is confirmed. As expected, longer n-alkyl ligands gradually show better substrate shielding properties. Above a certain critical ligand length, shielding by longer ligands inhibit the dissolution rate drastically by affecting the hydrolysis and dissolution processes. The type of solvent system used, in liquid chromatography practice or for dissolution studies as reported here, mainly affects the proportions of dissolved silicates in the eluent. On the basis of this in situ dissolution study a model for ligand and substrate hydrolysis and dissolution with the involved reactions is presented.</abstract><cop>United States</cop><pub>American Chemical Society</pub><doi>10.1021/ac00220a008</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0003-2700 |
| ispartof | Analytical chemistry (Washington), 1990-11, Vol.62 (21), p.2296-2300 |
| issn | 0003-2700 1520-6882 |
| language | eng |
| recordid | cdi_osti_scitechconnect_6105423 |
| source | American Chemical Society Journals |
| subjects | 400102 - Chemical & Spectral Procedures CALCULATION METHODS CHROMATOGRAPHY COLUMN PACKING EVEN-ODD NUCLEI EXTRACTION APPARATUSES EXTRACTION COLUMNS INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY ISOTOPES LIGHT NUCLEI LIQUID COLUMN CHROMATOGRAPHY MAGNETIC RESONANCE NUCLEAR MAGNETIC RESONANCE NUCLEI PACKINGS RESONANCE SEPARATION EQUIPMENT SEPARATION PROCESSES SILICON 29 SILICON ISOTOPES STABILITY STABLE ISOTOPES |
| title | Influence of alkyl chain length on the stability of n-alkyl-modified reversed phases. 2. Model dissolution study |
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