Effect of desipramine on dopamine receptor binding in vivo

Effect of desipramine (given i.p. 30 min prior to the tracer injection) on the in vivo binding of 3H-SCH23390 and 3H-N-methylspiperone ( 3H-NMSP) in mouse striatum was studied. The ratio of radioactivity in the striatum to that in the cerebellum at 15 min after i.v. injection of 3H-SCH23390 or 45 mi...

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Veröffentlicht in:	Life sciences (1973) 1990, Vol.47 (23), p.2119-2126
Hauptverfasser:	Suhara, Tetsuya, Inoue, Osamu, Kobayashi, Kaoru
Format:	Artikel
Sprache:	eng
Schlagworte:	550201 - Biochemistry- Tracer Techniques AFFINITY AMINES ANIMALS ANTIDEPRESSANTS Antidepressive Agents, Tricyclic - pharmacology AROMATICS AUTONOMIC NERVOUS SYSTEM AGENTS BASIC BIOLOGICAL SCIENCES Benzazepines - metabolism BIOCHEMICAL REACTION KINETICS Biological and medical sciences BIOLOGICAL EFFECTS BODY BRAIN CARDIOTONICS CARDIOVASCULAR AGENTS CENTRAL NERVOUS SYSTEM CENTRAL NERVOUS SYSTEM AGENTS Cerebellum - drug effects Corpus Striatum - drug effects desipramine Desipramine - pharmacology DOPAMINE Dose-Response Relationship, Drug DOSE-RESPONSE RELATIONSHIPS DRUGS HYDROGEN COMPOUNDS HYDROXY COMPOUNDS In Vitro Techniques ISOTOPE APPLICATIONS Ketanserin - pharmacology KINETICS Male MAMMALS Medical sciences MEMBRANE PROTEINS MICE neostriatum NERVOUS SYSTEM Neuropharmacology NEUROREGULATORS ORGANIC COMPOUNDS ORGANS Pharmacology. Drug treatments PHENOLS POLYPHENOLS PROTEINS Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology PSYCHOTROPIC DRUGS REACTION KINETICS RECEPTORS Receptors, Dopamine - metabolism RODENTS Spiperone - analogs & derivatives Spiperone - metabolism SYMPATHOMIMETICS TRACER TECHNIQUES TRITIUM COMPOUNDS VERTEBRATES
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