Use of yttrium-90-labeled anti-tac antibody in primate xenograft transplantation

The high-affinity interleukin-2 receptor (IL-2R) is expressed by T cells activated in response to foreign histocompatibility antigens but not by normal resting cells. Thus, blockade of the interaction of IL-2 with its receptor could achieve selective immunosuppression. Accordingly, anti-Tac, a murin...

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Veröffentlicht in:	Transplantation 1990-11, Vol.50 (5), p.760-765
Hauptverfasser:	COOPER, M. M, ROBBINS, R. C, GOLDMAN, G. K, MIRZADER, S, BRECHBIEL, M. W, STONE, C. D, GANSOW, O. A, CLARK, R. E, WALDMAN, T. A
Format:	Artikel
Sprache:	eng
Schlagworte:	550604 - Medicine- Unsealed Radionuclides in Therapy- (1980-) ANIMALS ANTIBODIES Antibodies, Anti-Idiotypic - biosynthesis Antibodies, Monoclonal - administration & dosage BETA DECAY RADIOISOTOPES BETA-MINUS DECAY RADIOISOTOPES Biological and medical sciences BODY CARDIOVASCULAR SYSTEM DAYS LIVING RADIOISOTOPES Graft Rejection - immunology Graft Rejection - radiation effects GRAFT-HOST REACTION GROWTH FACTORS HEART Heart Transplantation - immunology HOURS LIVING RADIOISOTOPES IMMUNOLOGY Immunomodulators IMMUNOSUPPRESSION IMMUNOTHERAPY Immunotoxins INTERMEDIATE MASS NUCLEI ISOMERIC TRANSITION ISOTOPES ISOTOPES LYMPHOKINES Macaca fascicularis Macaca mulatta MAMMALS Medical sciences MEDICINE MEMBRANE PROTEINS MICE MITOGENS MONKEYS MONOCLONAL ANTIBODIES NUCLEAR MEDICINE NUCLEI ODD-ODD NUCLEI ORGANIC COMPOUNDS ORGANS Pharmacology. Drug treatments PRIMATES PROTEINS RADIOIMMUNOLOGY RADIOIMMUNOTHERAPY RADIOISOTOPES RADIOLOGY RADIOLOGY AND NUCLEAR MEDICINE RADIOTHERAPY RECEPTORS Receptors, Interleukin-2 - immunology RODENTS SURVIVAL TIME THERAPY Transplantation, Heterologous Transplantation, Heterotopic TRANSPLANTS VERTEBRATES YTTRIUM 90 YTTRIUM ISOTOPES Yttrium Radioisotopes - pharmacology
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