Enumeration of 6-thioguanine-resistant T-lymphocytes in the peripheral blood of nonhuman primates (cynomolgus monkeys)

We have investigated the use of cynomolgus monkeys (Macaca fascicularis) as a model of somatic cell mutagenesis in non‐human primates. Using techniques described by Albertini (Mutation Research 150:411–422, 1985) for similar studies in humans, the frequency of TG‐resistant T‐lymphocytes in the perip...

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Veröffentlicht in:	Environmental and molecular mutagenesis 1991, Vol.18 (3), p.161-167
Hauptverfasser:	Zimmer, D. M., Aaron, C. S., O'Neill, J. P., Albertini, R. J., Carver, J. H., Hoffman, G. R.
Format:	Artikel
Sprache:	eng
Schlagworte:	560300 - Chemicals Metabolism & Toxicology ANIMAL CELLS ANIMALS Biological and medical sciences BIOLOGICAL EFFECTS BIOLOGICAL MATERIALS BLOOD BLOOD CELLS BODY FLUIDS Cell Division - drug effects Cell Line Chemical mutagenesis Clone Cells CONNECTIVE TISSUE CELLS Drug Resistance - immunology ENU Ethylnitrosourea - pharmacology Female GENETIC EFFECTS HPRT mutation LEUKOCYTES LYMPHOCYTES Macaca fascicularis Male MAMMALS MATERIALS Medical sciences Models, Genetic MONKEYS MUTAGENESIS MUTATION FREQUENCY MUTATIONS NITROSO COMPOUNDS NITROSOUREAS ORGANIC COMPOUNDS ORGANIC NITROGEN COMPOUNDS Phenotype PRIMATES RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT SOMATIC CELLS SOMATIC MUTATIONS T-lymphocyte T-Lymphocytes - drug effects T-Lymphocytes - immunology Thioguanine - pharmacology thioguanine resistant Toxicology VERTEBRATES
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