A more sensitive and specific radioenzymatic assay for catecholamines

This modification of the catechol-O-methyltransferase (COMT) based radioenzymatic assay for norepinephrine (NE) and epinephrine (E) improves sensitivity, selectivity and eliminates many inhibitors of COMT. Prior to assay, samples are extracted into heptane with diphenylborate, then into dilute aceti...

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Bibliographische Detailangaben
Veröffentlicht in:	Life sciences (1973) 1990, Vol.47 (23), p.2143-2153
Hauptverfasser:	Kennedy, Brian, Ziegler, Michael G.
Format:	Artikel
Sprache:	eng
Schlagworte:	550201 - Biochemistry- Tracer Techniques ADRENAL HORMONES ADRENALINE AMINES Animals AROMATICS AUTONOMIC NERVOUS SYSTEM AGENTS BASIC BIOLOGICAL SCIENCES Borates - chemistry CARDIOTONICS CARDIOVASCULAR AGENTS Catechol O-Methyltransferase - chemistry CATECHOLAMINES Catecholamines - analysis DRUGS ENZYMES Epinephrine - analysis EXTRACTION Humans HYDROXY COMPOUNDS METHYL TRANSFERASES NEUROREGULATORS NORADRENALINE Norepinephrine - analysis ORGANIC COMPOUNDS PHENOLS POLYPHENOLS RADIOENZYMATIC ASSAY Rats Reproducibility of Results Scintillation Counting - methods SENSITIVITY ANALYSIS Sensitivity and Specificity SEPARATION PROCESSES SOLVENT EXTRACTION SYMPATHOMIMETICS TRANSFERASES
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