Responses of the L5178Y mouse lymphoma cell forward mutation assay. V: 27 coded chemicals
Twenty‐seven chemicals were tested for their mutagenic potential in the L5178Y tk+/tk− mouse lymphoma cell forward mutation assay using procedures based upon those described by McGregor et al. (McGregor DB, Martin R, Cattanach P, Edwards I, McBride D, Caspary WJ (1987): Environ Mol Mutagen 9:143–160...
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| Veröffentlicht in: | Environmental and molecular mutagenesis 1991, Vol.17 (3), p.196-219 |
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| creator | McGregor, Douglas B. Brown, Alison G. Howgate, Susan McBride, Douglas Riach, Colin Caspary, William J. Carver, J. H. |
| description | Twenty‐seven chemicals were tested for their mutagenic potential in the L5178Y tk+/tk− mouse lymphoma cell forward mutation assay using procedures based upon those described by McGregor et al. (McGregor DB, Martin R, Cattanach P, Edwards I, McBride D, Caspary WJ (1987): Environ Mol Mutagen 9:143–160). Cultures were exposed to the chemicals for 4 hr, then cultured for 2 days before plating in soft agar with or without trifluorothymidine (TFT), 3 μg/ml. The chemicals were tested at least twice. Statistically significant responses were obtained with acid orange 10, aniline, benzaldehyde, o‐chloroaniline, chlorodibromomethane, cytembena, 1,2‐dibromo‐4‐(1,2‐dibromomethyl) cyclohexane, dieldrin, lithocholic acid, oxytetracycline, phenazopyridine HCl, 1‐phenyl‐3‐methyl‐5‐pyrazolone, sodium diethyldithiocarbamate, solvent yellow 14, tetraethylthiuram disulfide (disulfiram), 2,4‐toluene diisocyanate, and 2,6‐toluene diisocyanate. Apart from phenazopyridine HCl, acid orange 10, and solvent yellow 14, rat liver S9 mix was not a requirement for the mutagenic activity of these compounds. Chemicals not identified as mutagens were N‐4‐acetylaminofluorene, chlorpheniramine maleate, chlorpropamide, 1,4‐dioxane, endrin, ethylene glycol, iron dextran, methapyrilene, sodium(2‐ethylhexyl)alcohol sulfate, and 2,3,7,8‐tetra‐chlorodibenzo‐p‐dioxin. |
| doi_str_mv | 10.1002/em.2850170309 |
| format | Article |
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V: 27 coded chemicals</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>McGregor, Douglas B. ; Brown, Alison G. ; Howgate, Susan ; McBride, Douglas ; Riach, Colin ; Caspary, William J. ; Carver, J. H.</creator><creatorcontrib>McGregor, Douglas B. ; Brown, Alison G. ; Howgate, Susan ; McBride, Douglas ; Riach, Colin ; Caspary, William J. ; Carver, J. H.</creatorcontrib><description>Twenty‐seven chemicals were tested for their mutagenic potential in the L5178Y tk+/tk− mouse lymphoma cell forward mutation assay using procedures based upon those described by McGregor et al. (McGregor DB, Martin R, Cattanach P, Edwards I, McBride D, Caspary WJ (1987): Environ Mol Mutagen 9:143–160). Cultures were exposed to the chemicals for 4 hr, then cultured for 2 days before plating in soft agar with or without trifluorothymidine (TFT), 3 μg/ml. The chemicals were tested at least twice. Statistically significant responses were obtained with acid orange 10, aniline, benzaldehyde, o‐chloroaniline, chlorodibromomethane, cytembena, 1,2‐dibromo‐4‐(1,2‐dibromomethyl) cyclohexane, dieldrin, lithocholic acid, oxytetracycline, phenazopyridine HCl, 1‐phenyl‐3‐methyl‐5‐pyrazolone, sodium diethyldithiocarbamate, solvent yellow 14, tetraethylthiuram disulfide (disulfiram), 2,4‐toluene diisocyanate, and 2,6‐toluene diisocyanate. Apart from phenazopyridine HCl, acid orange 10, and solvent yellow 14, rat liver S9 mix was not a requirement for the mutagenic activity of these compounds. Chemicals not identified as mutagens were N‐4‐acetylaminofluorene, chlorpheniramine maleate, chlorpropamide, 1,4‐dioxane, endrin, ethylene glycol, iron dextran, methapyrilene, sodium(2‐ethylhexyl)alcohol sulfate, and 2,3,7,8‐tetra‐chlorodibenzo‐p‐dioxin.</description><identifier>ISSN: 0893-6692</identifier><identifier>EISSN: 1098-2280</identifier><identifier>DOI: 10.1002/em.2850170309</identifier><identifier>PMID: 1902415</identifier><identifier>CODEN: EMMUEG</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>3-METHYLCHOLANTHRENE ; 560300 - Chemicals Metabolism & Toxicology ; ACETYLAMINOFLUORENES ; ALDEHYDES ; AMINES ; ANILINE ; ANIMAL CELLS ; Animals ; AROMATICS ; BENZALDEHYDE ; Biological and medical sciences ; CONDENSED AROMATICS ; Data Interpretation, Statistical ; DIELDRIN ; DISEASES ; DOSE-RESPONSE RELATIONSHIPS ; Environmental pollutants toxicology ; Evaluation Studies as Topic ; GENE MUTATIONS ; HYDROCARBONS ; IMMUNE SYSTEM DISEASES ; INSECTICIDES ; LYMPHOMAS ; Male ; Medical sciences ; Mice ; Molecular Structure ; MUTAGEN SCREENING ; mutagenic compounds ; Mutagenicity Tests ; MUTAGENS ; Mutagens - toxicity ; MUTATIONS ; NEOPLASMS ; nonmutagenic compounds ; ORGANIC COMPOUNDS ; PESTICIDES ; POLYCYCLIC AROMATIC HYDROCARBONS ; Quality Control ; RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT ; Rats ; Rats, Inbred F344 ; SCREENING ; Thymidine Kinase - genetics ; Toxicology ; trifluorothymidine ; Trifluridine ; TUMOR CELLS ; Tumor Cells, Cultured</subject><ispartof>Environmental and molecular mutagenesis, 1991, Vol.17 (3), p.196-219</ispartof><rights>Copyright © 1991 Wiley‐Liss, Inc., A Wiley Company</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4729-5a31344b40c1b463f8e2d3a500f926992fc10146cb6fbf8be263ea981b0a66c3</citedby><cites>FETCH-LOGICAL-c4729-5a31344b40c1b463f8e2d3a500f926992fc10146cb6fbf8be263ea981b0a66c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fem.2850170309$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fem.2850170309$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,4010,27900,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19808388$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1902415$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/5929872$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>McGregor, Douglas B.</creatorcontrib><creatorcontrib>Brown, Alison G.</creatorcontrib><creatorcontrib>Howgate, Susan</creatorcontrib><creatorcontrib>McBride, Douglas</creatorcontrib><creatorcontrib>Riach, Colin</creatorcontrib><creatorcontrib>Caspary, William J.</creatorcontrib><creatorcontrib>Carver, J. H.</creatorcontrib><title>Responses of the L5178Y mouse lymphoma cell forward mutation assay. V: 27 coded chemicals</title><title>Environmental and molecular mutagenesis</title><addtitle>Environ. Mol. Mutagen</addtitle><description>Twenty‐seven chemicals were tested for their mutagenic potential in the L5178Y tk+/tk− mouse lymphoma cell forward mutation assay using procedures based upon those described by McGregor et al. (McGregor DB, Martin R, Cattanach P, Edwards I, McBride D, Caspary WJ (1987): Environ Mol Mutagen 9:143–160). Cultures were exposed to the chemicals for 4 hr, then cultured for 2 days before plating in soft agar with or without trifluorothymidine (TFT), 3 μg/ml. The chemicals were tested at least twice. Statistically significant responses were obtained with acid orange 10, aniline, benzaldehyde, o‐chloroaniline, chlorodibromomethane, cytembena, 1,2‐dibromo‐4‐(1,2‐dibromomethyl) cyclohexane, dieldrin, lithocholic acid, oxytetracycline, phenazopyridine HCl, 1‐phenyl‐3‐methyl‐5‐pyrazolone, sodium diethyldithiocarbamate, solvent yellow 14, tetraethylthiuram disulfide (disulfiram), 2,4‐toluene diisocyanate, and 2,6‐toluene diisocyanate. Apart from phenazopyridine HCl, acid orange 10, and solvent yellow 14, rat liver S9 mix was not a requirement for the mutagenic activity of these compounds. Chemicals not identified as mutagens were N‐4‐acetylaminofluorene, chlorpheniramine maleate, chlorpropamide, 1,4‐dioxane, endrin, ethylene glycol, iron dextran, methapyrilene, sodium(2‐ethylhexyl)alcohol sulfate, and 2,3,7,8‐tetra‐chlorodibenzo‐p‐dioxin.</description><subject>3-METHYLCHOLANTHRENE</subject><subject>560300 - Chemicals Metabolism & Toxicology</subject><subject>ACETYLAMINOFLUORENES</subject><subject>ALDEHYDES</subject><subject>AMINES</subject><subject>ANILINE</subject><subject>ANIMAL CELLS</subject><subject>Animals</subject><subject>AROMATICS</subject><subject>BENZALDEHYDE</subject><subject>Biological and medical sciences</subject><subject>CONDENSED AROMATICS</subject><subject>Data Interpretation, Statistical</subject><subject>DIELDRIN</subject><subject>DISEASES</subject><subject>DOSE-RESPONSE RELATIONSHIPS</subject><subject>Environmental pollutants toxicology</subject><subject>Evaluation Studies as Topic</subject><subject>GENE MUTATIONS</subject><subject>HYDROCARBONS</subject><subject>IMMUNE SYSTEM DISEASES</subject><subject>INSECTICIDES</subject><subject>LYMPHOMAS</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Molecular Structure</subject><subject>MUTAGEN SCREENING</subject><subject>mutagenic compounds</subject><subject>Mutagenicity Tests</subject><subject>MUTAGENS</subject><subject>Mutagens - toxicity</subject><subject>MUTATIONS</subject><subject>NEOPLASMS</subject><subject>nonmutagenic compounds</subject><subject>ORGANIC COMPOUNDS</subject><subject>PESTICIDES</subject><subject>POLYCYCLIC AROMATIC HYDROCARBONS</subject><subject>Quality Control</subject><subject>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</subject><subject>Rats</subject><subject>Rats, Inbred F344</subject><subject>SCREENING</subject><subject>Thymidine Kinase - genetics</subject><subject>Toxicology</subject><subject>trifluorothymidine</subject><subject>Trifluridine</subject><subject>TUMOR CELLS</subject><subject>Tumor Cells, Cultured</subject><issn>0893-6692</issn><issn>1098-2280</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEFv1DAQhS0EKtvCkSOShQS3LGM7cWxupWoL0rZIUFH1ZDnOWBuI48XOqt1_T1ZZUbhweof3zZuZR8grBksGwN9jWHJVAatBgH5CFgy0KjhX8JQsQGlRSKn5c3Kc8w8AxkrNj8gR08BLVi3I3VfMmzhkzDR6Oq6RripWqzsa4jYj7Xdhs47BUod9T31M9za1NGxHO3ZxoDZnu1vS7x8or6mLLbbUrTF0zvb5BXnmJ8GXBz0hNxfnN2efitWXy89np6vClTXXRWUFE2XZlOBYU0rhFfJW2ArAay615t4xYKV0jfSNVw1yKdBqxRqwUjpxQt7MsTGPncmuG9GtXRwGdKOpNNeq5hP0boY2Kf7aYh5N6PL-JTvg9KdhEyikVBNYzKBLMeeE3mxSF2zaGQZmX7fBYB7rnvjXh-BtE7B9pOd-J__twbd5KsUnO7gu_4UpUELt99Yzd9_1uPv_UnN-9c8Fh4u7POLDn0mbfhpZi7oyt9eXRl19-8gublfmWvwGAFCkOA</recordid><startdate>1991</startdate><enddate>1991</enddate><creator>McGregor, Douglas B.</creator><creator>Brown, Alison G.</creator><creator>Howgate, Susan</creator><creator>McBride, Douglas</creator><creator>Riach, Colin</creator><creator>Caspary, William J.</creator><creator>Carver, J. H.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>OTOTI</scope></search><sort><creationdate>1991</creationdate><title>Responses of the L5178Y mouse lymphoma cell forward mutation assay. V: 27 coded chemicals</title><author>McGregor, Douglas B. ; Brown, Alison G. ; Howgate, Susan ; McBride, Douglas ; Riach, Colin ; Caspary, William J. ; Carver, J. H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4729-5a31344b40c1b463f8e2d3a500f926992fc10146cb6fbf8be263ea981b0a66c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>3-METHYLCHOLANTHRENE</topic><topic>560300 - Chemicals Metabolism & Toxicology</topic><topic>ACETYLAMINOFLUORENES</topic><topic>ALDEHYDES</topic><topic>AMINES</topic><topic>ANILINE</topic><topic>ANIMAL CELLS</topic><topic>Animals</topic><topic>AROMATICS</topic><topic>BENZALDEHYDE</topic><topic>Biological and medical sciences</topic><topic>CONDENSED AROMATICS</topic><topic>Data Interpretation, Statistical</topic><topic>DIELDRIN</topic><topic>DISEASES</topic><topic>DOSE-RESPONSE RELATIONSHIPS</topic><topic>Environmental pollutants toxicology</topic><topic>Evaluation Studies as Topic</topic><topic>GENE MUTATIONS</topic><topic>HYDROCARBONS</topic><topic>IMMUNE SYSTEM DISEASES</topic><topic>INSECTICIDES</topic><topic>LYMPHOMAS</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Molecular Structure</topic><topic>MUTAGEN SCREENING</topic><topic>mutagenic compounds</topic><topic>Mutagenicity Tests</topic><topic>MUTAGENS</topic><topic>Mutagens - toxicity</topic><topic>MUTATIONS</topic><topic>NEOPLASMS</topic><topic>nonmutagenic compounds</topic><topic>ORGANIC COMPOUNDS</topic><topic>PESTICIDES</topic><topic>POLYCYCLIC AROMATIC HYDROCARBONS</topic><topic>Quality Control</topic><topic>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</topic><topic>Rats</topic><topic>Rats, Inbred F344</topic><topic>SCREENING</topic><topic>Thymidine Kinase - genetics</topic><topic>Toxicology</topic><topic>trifluorothymidine</topic><topic>Trifluridine</topic><topic>TUMOR CELLS</topic><topic>Tumor Cells, Cultured</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>McGregor, Douglas B.</creatorcontrib><creatorcontrib>Brown, Alison G.</creatorcontrib><creatorcontrib>Howgate, Susan</creatorcontrib><creatorcontrib>McBride, Douglas</creatorcontrib><creatorcontrib>Riach, Colin</creatorcontrib><creatorcontrib>Caspary, William J.</creatorcontrib><creatorcontrib>Carver, J. H.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>OSTI.GOV</collection><jtitle>Environmental and molecular mutagenesis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>McGregor, Douglas B.</au><au>Brown, Alison G.</au><au>Howgate, Susan</au><au>McBride, Douglas</au><au>Riach, Colin</au><au>Caspary, William J.</au><au>Carver, J. H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Responses of the L5178Y mouse lymphoma cell forward mutation assay. V: 27 coded chemicals</atitle><jtitle>Environmental and molecular mutagenesis</jtitle><addtitle>Environ. Mol. Mutagen</addtitle><date>1991</date><risdate>1991</risdate><volume>17</volume><issue>3</issue><spage>196</spage><epage>219</epage><pages>196-219</pages><issn>0893-6692</issn><eissn>1098-2280</eissn><coden>EMMUEG</coden><abstract>Twenty‐seven chemicals were tested for their mutagenic potential in the L5178Y tk+/tk− mouse lymphoma cell forward mutation assay using procedures based upon those described by McGregor et al. (McGregor DB, Martin R, Cattanach P, Edwards I, McBride D, Caspary WJ (1987): Environ Mol Mutagen 9:143–160). Cultures were exposed to the chemicals for 4 hr, then cultured for 2 days before plating in soft agar with or without trifluorothymidine (TFT), 3 μg/ml. The chemicals were tested at least twice. Statistically significant responses were obtained with acid orange 10, aniline, benzaldehyde, o‐chloroaniline, chlorodibromomethane, cytembena, 1,2‐dibromo‐4‐(1,2‐dibromomethyl) cyclohexane, dieldrin, lithocholic acid, oxytetracycline, phenazopyridine HCl, 1‐phenyl‐3‐methyl‐5‐pyrazolone, sodium diethyldithiocarbamate, solvent yellow 14, tetraethylthiuram disulfide (disulfiram), 2,4‐toluene diisocyanate, and 2,6‐toluene diisocyanate. Apart from phenazopyridine HCl, acid orange 10, and solvent yellow 14, rat liver S9 mix was not a requirement for the mutagenic activity of these compounds. Chemicals not identified as mutagens were N‐4‐acetylaminofluorene, chlorpheniramine maleate, chlorpropamide, 1,4‐dioxane, endrin, ethylene glycol, iron dextran, methapyrilene, sodium(2‐ethylhexyl)alcohol sulfate, and 2,3,7,8‐tetra‐chlorodibenzo‐p‐dioxin.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>1902415</pmid><doi>10.1002/em.2850170309</doi><tpages>24</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0893-6692 |
| ispartof | Environmental and molecular mutagenesis, 1991, Vol.17 (3), p.196-219 |
| issn | 0893-6692 1098-2280 |
| language | eng |
| recordid | cdi_osti_scitechconnect_5929872 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | 3-METHYLCHOLANTHRENE 560300 - Chemicals Metabolism & Toxicology ACETYLAMINOFLUORENES ALDEHYDES AMINES ANILINE ANIMAL CELLS Animals AROMATICS BENZALDEHYDE Biological and medical sciences CONDENSED AROMATICS Data Interpretation, Statistical DIELDRIN DISEASES DOSE-RESPONSE RELATIONSHIPS Environmental pollutants toxicology Evaluation Studies as Topic GENE MUTATIONS HYDROCARBONS IMMUNE SYSTEM DISEASES INSECTICIDES LYMPHOMAS Male Medical sciences Mice Molecular Structure MUTAGEN SCREENING mutagenic compounds Mutagenicity Tests MUTAGENS Mutagens - toxicity MUTATIONS NEOPLASMS nonmutagenic compounds ORGANIC COMPOUNDS PESTICIDES POLYCYCLIC AROMATIC HYDROCARBONS Quality Control RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT Rats Rats, Inbred F344 SCREENING Thymidine Kinase - genetics Toxicology trifluorothymidine Trifluridine TUMOR CELLS Tumor Cells, Cultured |
| title | Responses of the L5178Y mouse lymphoma cell forward mutation assay. V: 27 coded chemicals |
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