The efficacy of chlorhexidine gel in reduction of Streptococcus mutans and Lactobacillus species in patients treated with radiation therapy
Xerostomia may develop in patients with cancer who receive radiotherapy that includes the salivary glands in the field. These patients are at high risk of rampant dental caries. Streptococcus mutans and Lactobacillus species have been associated with dental caries. Quantitative counts of these organ...
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| Veröffentlicht in: | Oral surgery, oral medicine, oral pathology oral medicine, oral pathology, 1991-02, Vol.71 (2), p.172-178 |
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| container_title | Oral surgery, oral medicine, oral pathology |
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| creator | Epstein, Joel B. McBride, Barry C. Stevenson-Moore, Peter Merilees, Heather Spinelli, John |
| description | Xerostomia may develop in patients with cancer who receive radiotherapy that includes the salivary glands in the field. These patients are at high risk of rampant dental caries.
Streptococcus mutans and
Lactobacillus species have been associated with dental caries. Quantitative counts of these organisms demonstrated high caries risk due to streptococci in 66% and due to lactobacilli in 100% of patients studied. Use of chlorhexidine rinse was shown to reduce
S. mutans counts 1.1 logs and lactobacilli 1.1 logs. The use of chlorhexidine gel resulted in a reduction of
S. mutans 1.2 logs and lactobacilli 2.2 logs. In the subjects using the rinse, caries risk due to streptococci was reduced to low levels in 44% and due to lactobacilli in only one subject, with reduction to moderate risk in one third and no change in risk in the remaining patients. The use of chlorhexidine gel was found to reduce the caries risk associated with streptococci to low levels in all patients, and the risk associated with lactobacilli to low and moderate risk in two thirds of patients. |
| doi_str_mv | 10.1016/0030-4220(91)90461-K |
| format | Article |
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Streptococcus mutans and
Lactobacillus species have been associated with dental caries. Quantitative counts of these organisms demonstrated high caries risk due to streptococci in 66% and due to lactobacilli in 100% of patients studied. Use of chlorhexidine rinse was shown to reduce
S. mutans counts 1.1 logs and lactobacilli 1.1 logs. The use of chlorhexidine gel resulted in a reduction of
S. mutans 1.2 logs and lactobacilli 2.2 logs. In the subjects using the rinse, caries risk due to streptococci was reduced to low levels in 44% and due to lactobacilli in only one subject, with reduction to moderate risk in one third and no change in risk in the remaining patients. The use of chlorhexidine gel was found to reduce the caries risk associated with streptococci to low levels in all patients, and the risk associated with lactobacilli to low and moderate risk in two thirds of patients.</description><identifier>ISSN: 0030-4220</identifier><identifier>EISSN: 1878-2175</identifier><identifier>DOI: 10.1016/0030-4220(91)90461-K</identifier><identifier>PMID: 1900602</identifier><identifier>CODEN: OSOMAE</identifier><language>eng</language><publisher>Saint Louis, MO: Elsevier Inc</publisher><subject>560151 - Radiation Effects on Animals- Man ; Adult ; Aged ; ANTI-INFECTIVE AGENTS ; ANTIBIOTICS ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antiseptics ; BACTERIAL DISEASES ; Biological and medical sciences ; BIOLOGICAL EFFECTS ; CARIES ; Chlorhexidine - analogs & derivatives ; Chlorhexidine - pharmacology ; Chlorhexidine - therapeutic use ; Colony Count, Microbial ; Dental Caries - microbiology ; Dental Caries - prevention & control ; DENTISTRY ; DISEASES ; DRUGS ; Female ; Head and Neck Neoplasms - radiotherapy ; Humans ; INFECTIOUS DISEASES ; Lactobacillus - drug effects ; Male ; Medical sciences ; MEDICINE ; Middle Aged ; NUCLEAR MEDICINE ; PATHOLOGICAL CHANGES ; PATIENTS ; Pharmacology. Drug treatments ; RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT ; RADIOINDUCTION ; RADIOLOGY ; RADIOTHERAPY ; Radiotherapy, High-Energy - adverse effects ; RISK ASSESSMENT ; Saliva - microbiology ; Salivation - radiation effects ; SIDE EFFECTS ; SKIN DISEASES ; Streptococcus mutans - drug effects ; THERAPY ; Xerostomia - etiology</subject><ispartof>Oral surgery, oral medicine, oral pathology, 1991-02, Vol.71 (2), p.172-178</ispartof><rights>1991 Mosby-Year Book, Inc. All rights reserved</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4977468$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1900602$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/5924811$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Epstein, Joel B.</creatorcontrib><creatorcontrib>McBride, Barry C.</creatorcontrib><creatorcontrib>Stevenson-Moore, Peter</creatorcontrib><creatorcontrib>Merilees, Heather</creatorcontrib><creatorcontrib>Spinelli, John</creatorcontrib><title>The efficacy of chlorhexidine gel in reduction of Streptococcus mutans and Lactobacillus species in patients treated with radiation therapy</title><title>Oral surgery, oral medicine, oral pathology</title><addtitle>Oral Surg Oral Med Oral Pathol</addtitle><description>Xerostomia may develop in patients with cancer who receive radiotherapy that includes the salivary glands in the field. These patients are at high risk of rampant dental caries.
Streptococcus mutans and
Lactobacillus species have been associated with dental caries. Quantitative counts of these organisms demonstrated high caries risk due to streptococci in 66% and due to lactobacilli in 100% of patients studied. Use of chlorhexidine rinse was shown to reduce
S. mutans counts 1.1 logs and lactobacilli 1.1 logs. The use of chlorhexidine gel resulted in a reduction of
S. mutans 1.2 logs and lactobacilli 2.2 logs. In the subjects using the rinse, caries risk due to streptococci was reduced to low levels in 44% and due to lactobacilli in only one subject, with reduction to moderate risk in one third and no change in risk in the remaining patients. The use of chlorhexidine gel was found to reduce the caries risk associated with streptococci to low levels in all patients, and the risk associated with lactobacilli to low and moderate risk in two thirds of patients.</description><subject>560151 - Radiation Effects on Animals- Man</subject><subject>Adult</subject><subject>Aged</subject><subject>ANTI-INFECTIVE AGENTS</subject><subject>ANTIBIOTICS</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antiseptics</subject><subject>BACTERIAL DISEASES</subject><subject>Biological and medical sciences</subject><subject>BIOLOGICAL EFFECTS</subject><subject>CARIES</subject><subject>Chlorhexidine - analogs & derivatives</subject><subject>Chlorhexidine - pharmacology</subject><subject>Chlorhexidine - therapeutic use</subject><subject>Colony Count, Microbial</subject><subject>Dental Caries - microbiology</subject><subject>Dental Caries - prevention & control</subject><subject>DENTISTRY</subject><subject>DISEASES</subject><subject>DRUGS</subject><subject>Female</subject><subject>Head and Neck Neoplasms - radiotherapy</subject><subject>Humans</subject><subject>INFECTIOUS DISEASES</subject><subject>Lactobacillus - drug effects</subject><subject>Male</subject><subject>Medical sciences</subject><subject>MEDICINE</subject><subject>Middle Aged</subject><subject>NUCLEAR MEDICINE</subject><subject>PATHOLOGICAL CHANGES</subject><subject>PATIENTS</subject><subject>Pharmacology. Drug treatments</subject><subject>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</subject><subject>RADIOINDUCTION</subject><subject>RADIOLOGY</subject><subject>RADIOTHERAPY</subject><subject>Radiotherapy, High-Energy - adverse effects</subject><subject>RISK ASSESSMENT</subject><subject>Saliva - microbiology</subject><subject>Salivation - radiation effects</subject><subject>SIDE EFFECTS</subject><subject>SKIN DISEASES</subject><subject>Streptococcus mutans - drug effects</subject><subject>THERAPY</subject><subject>Xerostomia - etiology</subject><issn>0030-4220</issn><issn>1878-2175</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kc9uFDEMxiMEKtvCG4AUoR7gMJBk_uaChCoKqCv1QDlHHsdhgmYzoyQL3WfoSzPTXfVkWd_vs2V_jL2R4qMUsvkkRCmKSinxXssPWlSNLG6esY3s2q5Qsq2fs80T8pKdp_RnaduqKc_YmdRCNEJt2MPdQJyc8wh44JPjOIxTHOjeWx-I_6aR-8Aj2T1mP4WV-JkjzXnCCXGf-G6fISQOwfItYJ56QD-Oi5BmQk9ptc-QPYWc-OKETJb_83ngEayHx6F5oAjz4RV74WBM9PpUL9iv6693V9-L7e23H1dftgWpSueig941FfTaORK9rnXd1crpWihdO1TUQdVJiaSca6TSVMsKqNStLdFC1arygr07zp1S9iahz4QDTiEQZlNrtdoX6O0Rmvf9jqyZo99BPJjT5xb98qRDQhhdhIA-PWGVbpdXdwv2-YjRctBfT3HdRwHJ-rius5M3Upg1ULOmZda0jJbmMVBzU_4HBoiUJw</recordid><startdate>19910201</startdate><enddate>19910201</enddate><creator>Epstein, Joel B.</creator><creator>McBride, Barry C.</creator><creator>Stevenson-Moore, Peter</creator><creator>Merilees, Heather</creator><creator>Spinelli, John</creator><general>Elsevier Inc</general><general>Mosby</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>OTOTI</scope></search><sort><creationdate>19910201</creationdate><title>The efficacy of chlorhexidine gel in reduction of Streptococcus mutans and Lactobacillus species in patients treated with radiation therapy</title><author>Epstein, Joel B. ; McBride, Barry C. ; Stevenson-Moore, Peter ; Merilees, Heather ; Spinelli, John</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e249t-8abf64ab9ffe0b9595852f950295fc2e8a4811ce2ff6129e514ae397d3cda4723</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>560151 - Radiation Effects on Animals- Man</topic><topic>Adult</topic><topic>Aged</topic><topic>ANTI-INFECTIVE AGENTS</topic><topic>ANTIBIOTICS</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Antiseptics</topic><topic>BACTERIAL DISEASES</topic><topic>Biological and medical sciences</topic><topic>BIOLOGICAL EFFECTS</topic><topic>CARIES</topic><topic>Chlorhexidine - analogs & derivatives</topic><topic>Chlorhexidine - pharmacology</topic><topic>Chlorhexidine - therapeutic use</topic><topic>Colony Count, Microbial</topic><topic>Dental Caries - microbiology</topic><topic>Dental Caries - prevention & control</topic><topic>DENTISTRY</topic><topic>DISEASES</topic><topic>DRUGS</topic><topic>Female</topic><topic>Head and Neck Neoplasms - radiotherapy</topic><topic>Humans</topic><topic>INFECTIOUS DISEASES</topic><topic>Lactobacillus - drug effects</topic><topic>Male</topic><topic>Medical sciences</topic><topic>MEDICINE</topic><topic>Middle Aged</topic><topic>NUCLEAR MEDICINE</topic><topic>PATHOLOGICAL CHANGES</topic><topic>PATIENTS</topic><topic>Pharmacology. Drug treatments</topic><topic>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</topic><topic>RADIOINDUCTION</topic><topic>RADIOLOGY</topic><topic>RADIOTHERAPY</topic><topic>Radiotherapy, High-Energy - adverse effects</topic><topic>RISK ASSESSMENT</topic><topic>Saliva - microbiology</topic><topic>Salivation - radiation effects</topic><topic>SIDE EFFECTS</topic><topic>SKIN DISEASES</topic><topic>Streptococcus mutans - drug effects</topic><topic>THERAPY</topic><topic>Xerostomia - etiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Epstein, Joel B.</creatorcontrib><creatorcontrib>McBride, Barry C.</creatorcontrib><creatorcontrib>Stevenson-Moore, Peter</creatorcontrib><creatorcontrib>Merilees, Heather</creatorcontrib><creatorcontrib>Spinelli, John</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>OSTI.GOV</collection><jtitle>Oral surgery, oral medicine, oral pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Epstein, Joel B.</au><au>McBride, Barry C.</au><au>Stevenson-Moore, Peter</au><au>Merilees, Heather</au><au>Spinelli, John</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The efficacy of chlorhexidine gel in reduction of Streptococcus mutans and Lactobacillus species in patients treated with radiation therapy</atitle><jtitle>Oral surgery, oral medicine, oral pathology</jtitle><addtitle>Oral Surg Oral Med Oral Pathol</addtitle><date>1991-02-01</date><risdate>1991</risdate><volume>71</volume><issue>2</issue><spage>172</spage><epage>178</epage><pages>172-178</pages><issn>0030-4220</issn><eissn>1878-2175</eissn><coden>OSOMAE</coden><abstract>Xerostomia may develop in patients with cancer who receive radiotherapy that includes the salivary glands in the field. These patients are at high risk of rampant dental caries.
Streptococcus mutans and
Lactobacillus species have been associated with dental caries. Quantitative counts of these organisms demonstrated high caries risk due to streptococci in 66% and due to lactobacilli in 100% of patients studied. Use of chlorhexidine rinse was shown to reduce
S. mutans counts 1.1 logs and lactobacilli 1.1 logs. The use of chlorhexidine gel resulted in a reduction of
S. mutans 1.2 logs and lactobacilli 2.2 logs. In the subjects using the rinse, caries risk due to streptococci was reduced to low levels in 44% and due to lactobacilli in only one subject, with reduction to moderate risk in one third and no change in risk in the remaining patients. The use of chlorhexidine gel was found to reduce the caries risk associated with streptococci to low levels in all patients, and the risk associated with lactobacilli to low and moderate risk in two thirds of patients.</abstract><cop>Saint Louis, MO</cop><pub>Elsevier Inc</pub><pmid>1900602</pmid><doi>10.1016/0030-4220(91)90461-K</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0030-4220 |
| ispartof | Oral surgery, oral medicine, oral pathology, 1991-02, Vol.71 (2), p.172-178 |
| issn | 0030-4220 1878-2175 |
| language | eng |
| recordid | cdi_osti_scitechconnect_5924811 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | 560151 - Radiation Effects on Animals- Man Adult Aged ANTI-INFECTIVE AGENTS ANTIBIOTICS Antibiotics. Antiinfectious agents. Antiparasitic agents Antiseptics BACTERIAL DISEASES Biological and medical sciences BIOLOGICAL EFFECTS CARIES Chlorhexidine - analogs & derivatives Chlorhexidine - pharmacology Chlorhexidine - therapeutic use Colony Count, Microbial Dental Caries - microbiology Dental Caries - prevention & control DENTISTRY DISEASES DRUGS Female Head and Neck Neoplasms - radiotherapy Humans INFECTIOUS DISEASES Lactobacillus - drug effects Male Medical sciences MEDICINE Middle Aged NUCLEAR MEDICINE PATHOLOGICAL CHANGES PATIENTS Pharmacology. Drug treatments RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RADIOINDUCTION RADIOLOGY RADIOTHERAPY Radiotherapy, High-Energy - adverse effects RISK ASSESSMENT Saliva - microbiology Salivation - radiation effects SIDE EFFECTS SKIN DISEASES Streptococcus mutans - drug effects THERAPY Xerostomia - etiology |
| title | The efficacy of chlorhexidine gel in reduction of Streptococcus mutans and Lactobacillus species in patients treated with radiation therapy |
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