Regional cardiac adrenergic function using I-123 meta-iodobenzylguanidine tomographic imaging after acute myocardial infarction
The effect of acute myocardial infarction (AMI) on regional cardiac adrenergic function was studied in 27 patients mean ± standard deviation 10 ± 4 days after AMI. Regional adrenergk function was evaluated noninvasively with I-123 meta-iodobenzylguanidine (MIBG) using a dedicated 3-detector tomograp...
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| Veröffentlicht in: | The American journal of cardiology 1991-02, Vol.67 (4), p.236-242 |
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| creator | McGhie, A.Iain Corbett, James R. Akers, Marvin S. Kulkarni, Padmakur Sills, Michael N. Kremers, Mark Buja, L.Maximilian Durant-Reville, Marc Parkey, Robert W. Willerson, James T. |
| description | The effect of acute myocardial infarction (AMI) on regional cardiac adrenergic function was studied in 27 patients mean ± standard deviation 10 ± 4 days after AMI. Regional adrenergk function was evaluated noninvasively with I-123 meta-iodobenzylguanidine (MIBG) using a dedicated 3-detector tomograph. Four hours after its administration, there was reduced MIBG uptake in the region of infarction, 0.38 ± 0.31 counts/pixel/mCi × 103 compared with 0.60 ± 0.30 counts/pixel/mCi × 103 and 0.92 ± 0.35 counts/pixel/mCi × 103 in the zones bordering and distant from the infarct area, respectively, p < 0.001. In all patients, the area of reduced MIBG uptake after 4 hours was more extensive than the associated thallium-201 perfusion defect with defect scores of 52 ± 22 and 23 ± 18%, respectively, p < 0.001. After anterior wall AMI, the 4-hour MIBG defect score was 70 ± 13% and the degree of mismatch between myocardial perfusion and MIBG uptake was 30 ± 9% compared with 39 ± 17 and 21 ± 17% after inferior AMI, p < 0.001 and p = 0.016, respectively. The 4-hour MIBG defect score correlated inversely with the predischarge left ventricular ejection fraction, r = −0.73, p < 0.001. Patients with ventricular arrhythmia of ≥1 ventricular premature complexes per hour, paired ventricular premature complexes or ventricular tachycardia detected during the late hospital phase had higher 4-hour MIBG defect scores, 62.5 ± 15.0%, than patients with no detectable complex ventricular ectopic activity and a ventricular premature complex frequency of |
| doi_str_mv | 10.1016/0002-9149(91)90552-V |
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| fullrecord | <record><control><sourceid>proquest_osti_</sourceid><recordid>TN_cdi_osti_scitechconnect_5893962</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>000291499190552V</els_id><sourcerecordid>80433943</sourcerecordid><originalsourceid>FETCH-LOGICAL-c329t-28bfe88eb70b973d20c04210a892d43dba936d6142dedae57d3cbaf50c2926e73</originalsourceid><addsrcrecordid>eNp9kUuLFTEQhYMo452r_0ChERx00ZpHv7IRZPAxMCCIzjZUJ9U9ke7kmqSF68a_bnr6oq5cJCHUd05Spwh5wugrRlnzmlLKS8kq-UKyl5LWNS9v7pEd61pZMsnEfbL7gzwk5zF-y1fG6uaMnDEpadvVO_LrM47WO5gKDcFY0AWYgA7DaHUxLE6nXC2WaN1YXJWMi2LGBKX1xvfofh6ncQFnjXVYJD_7McDhNivtDOMqgSFhKEAvCYv56Lc3psK6AcKd9SPyYIAp4uPTuSdf37_7cvmxvP704ery7XWpBZep5F0_YNdh39JetsJwqmnFGYVOclMJ04MUjWlYxQ0awLo1Qvcw1FRzyRtsxZ4823x9TFZFbRPqW-2dQ51U3UkhG56hiw06BP99wZjUbKPGaQKHfomqo5UQMq89qTZQBx9jwEEdQm45HBWjah2OWpNXa_J5U3fDUTdZ9vTkv_Qzmr-ibRq5_vxUh6hhGgI4beM_WMNExZvMvdk4zIn9sBjWhtBpNDas_Rhv__-R31b8rUw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>80433943</pqid></control><display><type>article</type><title>Regional cardiac adrenergic function using I-123 meta-iodobenzylguanidine tomographic imaging after acute myocardial infarction</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>McGhie, A.Iain ; Corbett, James R. ; Akers, Marvin S. ; Kulkarni, Padmakur ; Sills, Michael N. ; Kremers, Mark ; Buja, L.Maximilian ; Durant-Reville, Marc ; Parkey, Robert W. ; Willerson, James T.</creator><creatorcontrib>McGhie, A.Iain ; Corbett, James R. ; Akers, Marvin S. ; Kulkarni, Padmakur ; Sills, Michael N. ; Kremers, Mark ; Buja, L.Maximilian ; Durant-Reville, Marc ; Parkey, Robert W. ; Willerson, James T.</creatorcontrib><description>The effect of acute myocardial infarction (AMI) on regional cardiac adrenergic function was studied in 27 patients mean ± standard deviation 10 ± 4 days after AMI. Regional adrenergk function was evaluated noninvasively with I-123 meta-iodobenzylguanidine (MIBG) using a dedicated 3-detector tomograph. Four hours after its administration, there was reduced MIBG uptake in the region of infarction, 0.38 ± 0.31 counts/pixel/mCi × 103 compared with 0.60 ± 0.30 counts/pixel/mCi × 103 and 0.92 ± 0.35 counts/pixel/mCi × 103 in the zones bordering and distant from the infarct area, respectively, p < 0.001. In all patients, the area of reduced MIBG uptake after 4 hours was more extensive than the associated thallium-201 perfusion defect with defect scores of 52 ± 22 and 23 ± 18%, respectively, p < 0.001. After anterior wall AMI, the 4-hour MIBG defect score was 70 ± 13% and the degree of mismatch between myocardial perfusion and MIBG uptake was 30 ± 9% compared with 39 ± 17 and 21 ± 17% after inferior AMI, p < 0.001 and p = 0.016, respectively. The 4-hour MIBG defect score correlated inversely with the predischarge left ventricular ejection fraction, r = −0.73, p < 0.001. Patients with ventricular arrhythmia of ≥1 ventricular premature complexes per hour, paired ventricular premature complexes or ventricular tachycardia detected during the late hospital phase had higher 4-hour MIBG defect scores, 62.5 ± 15.0%, than patients with no detectable complex ventricular ectopic activity and a ventricular premature complex frequency of <1 per hour, 44.6 ± 23.4%, p = 0.036. These data suggest that after acute AMI in humans (1) the abnormality in adrenergic function is more extensive than the associated abnormality in myocardial perfusion; (2) anterior wall AMI is associated with greater disruption of cardiac adrenergic function than other infarcts; (3) the severity of cardiac adrenergic dysfunction correlates with the degree of left ventricular dysfunction; and (4) the abnormality in regional adrenergic function may be associated with the presence of ventricular ectopic activity after AMI.</description><identifier>ISSN: 0002-9149</identifier><identifier>EISSN: 1879-1913</identifier><identifier>DOI: 10.1016/0002-9149(91)90552-V</identifier><identifier>PMID: 1990785</identifier><identifier>CODEN: AJCDAG</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>3-Iodobenzylguanidine ; 550601 - Medicine- Unsealed Radionuclides in Diagnostics ; Adult ; Aged ; Arrhythmias, Cardiac - complications ; BETA DECAY RADIOISOTOPES ; Biological and medical sciences ; BIOMEDICAL RADIOGRAPHY ; BODY ; Cardiology. Vascular system ; CARDIOVASCULAR DISEASES ; CARDIOVASCULAR SYSTEM ; Catecholamines - blood ; COMPUTERIZED TOMOGRAPHY ; Contrast Media ; Coronary heart disease ; DIAGNOSIS ; DIAGNOSTIC TECHNIQUES ; DISEASES ; ELECTRON CAPTURE RADIOISOTOPES ; EMISSION COMPUTED TOMOGRAPHY ; Female ; HEART ; HOURS LIVING RADIOISOTOPES ; Humans ; IMAGE PROCESSING ; INTERMEDIATE MASS NUCLEI ; IODINE 123 ; IODINE ISOTOPES ; Iodine Radioisotopes ; Iodobenzenes ; ISOTOPES ; Male ; Medical sciences ; MEDICINE ; Middle Aged ; MYOCARDIAL INFARCTION ; Myocardial Infarction - complications ; Myocardial Infarction - diagnostic imaging ; Myocardial Infarction - physiopathology ; NUCLEAR MEDICINE ; NUCLEI ; ODD-EVEN NUCLEI ; ORGANS ; PATIENTS ; PROCESSING ; RADIOISOTOPES ; RADIOLOGY ; RADIOLOGY AND NUCLEAR MEDICINE ; Sympathetic Nervous System - physiopathology ; Thallium Radioisotopes ; TOMOGRAPHY ; Tomography, Emission-Computed ; Ventricular Function, Left</subject><ispartof>The American journal of cardiology, 1991-02, Vol.67 (4), p.236-242</ispartof><rights>1991</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c329t-28bfe88eb70b973d20c04210a892d43dba936d6142dedae57d3cbaf50c2926e73</citedby><cites>FETCH-LOGICAL-c329t-28bfe88eb70b973d20c04210a892d43dba936d6142dedae57d3cbaf50c2926e73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/000291499190552V$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19613426$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1990785$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/5893962$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>McGhie, A.Iain</creatorcontrib><creatorcontrib>Corbett, James R.</creatorcontrib><creatorcontrib>Akers, Marvin S.</creatorcontrib><creatorcontrib>Kulkarni, Padmakur</creatorcontrib><creatorcontrib>Sills, Michael N.</creatorcontrib><creatorcontrib>Kremers, Mark</creatorcontrib><creatorcontrib>Buja, L.Maximilian</creatorcontrib><creatorcontrib>Durant-Reville, Marc</creatorcontrib><creatorcontrib>Parkey, Robert W.</creatorcontrib><creatorcontrib>Willerson, James T.</creatorcontrib><title>Regional cardiac adrenergic function using I-123 meta-iodobenzylguanidine tomographic imaging after acute myocardial infarction</title><title>The American journal of cardiology</title><addtitle>Am J Cardiol</addtitle><description>The effect of acute myocardial infarction (AMI) on regional cardiac adrenergic function was studied in 27 patients mean ± standard deviation 10 ± 4 days after AMI. Regional adrenergk function was evaluated noninvasively with I-123 meta-iodobenzylguanidine (MIBG) using a dedicated 3-detector tomograph. Four hours after its administration, there was reduced MIBG uptake in the region of infarction, 0.38 ± 0.31 counts/pixel/mCi × 103 compared with 0.60 ± 0.30 counts/pixel/mCi × 103 and 0.92 ± 0.35 counts/pixel/mCi × 103 in the zones bordering and distant from the infarct area, respectively, p < 0.001. In all patients, the area of reduced MIBG uptake after 4 hours was more extensive than the associated thallium-201 perfusion defect with defect scores of 52 ± 22 and 23 ± 18%, respectively, p < 0.001. After anterior wall AMI, the 4-hour MIBG defect score was 70 ± 13% and the degree of mismatch between myocardial perfusion and MIBG uptake was 30 ± 9% compared with 39 ± 17 and 21 ± 17% after inferior AMI, p < 0.001 and p = 0.016, respectively. The 4-hour MIBG defect score correlated inversely with the predischarge left ventricular ejection fraction, r = −0.73, p < 0.001. Patients with ventricular arrhythmia of ≥1 ventricular premature complexes per hour, paired ventricular premature complexes or ventricular tachycardia detected during the late hospital phase had higher 4-hour MIBG defect scores, 62.5 ± 15.0%, than patients with no detectable complex ventricular ectopic activity and a ventricular premature complex frequency of <1 per hour, 44.6 ± 23.4%, p = 0.036. These data suggest that after acute AMI in humans (1) the abnormality in adrenergic function is more extensive than the associated abnormality in myocardial perfusion; (2) anterior wall AMI is associated with greater disruption of cardiac adrenergic function than other infarcts; (3) the severity of cardiac adrenergic dysfunction correlates with the degree of left ventricular dysfunction; and (4) the abnormality in regional adrenergic function may be associated with the presence of ventricular ectopic activity after AMI.</description><subject>3-Iodobenzylguanidine</subject><subject>550601 - Medicine- Unsealed Radionuclides in Diagnostics</subject><subject>Adult</subject><subject>Aged</subject><subject>Arrhythmias, Cardiac - complications</subject><subject>BETA DECAY RADIOISOTOPES</subject><subject>Biological and medical sciences</subject><subject>BIOMEDICAL RADIOGRAPHY</subject><subject>BODY</subject><subject>Cardiology. Vascular system</subject><subject>CARDIOVASCULAR DISEASES</subject><subject>CARDIOVASCULAR SYSTEM</subject><subject>Catecholamines - blood</subject><subject>COMPUTERIZED TOMOGRAPHY</subject><subject>Contrast Media</subject><subject>Coronary heart disease</subject><subject>DIAGNOSIS</subject><subject>DIAGNOSTIC TECHNIQUES</subject><subject>DISEASES</subject><subject>ELECTRON CAPTURE RADIOISOTOPES</subject><subject>EMISSION COMPUTED TOMOGRAPHY</subject><subject>Female</subject><subject>HEART</subject><subject>HOURS LIVING RADIOISOTOPES</subject><subject>Humans</subject><subject>IMAGE PROCESSING</subject><subject>INTERMEDIATE MASS NUCLEI</subject><subject>IODINE 123</subject><subject>IODINE ISOTOPES</subject><subject>Iodine Radioisotopes</subject><subject>Iodobenzenes</subject><subject>ISOTOPES</subject><subject>Male</subject><subject>Medical sciences</subject><subject>MEDICINE</subject><subject>Middle Aged</subject><subject>MYOCARDIAL INFARCTION</subject><subject>Myocardial Infarction - complications</subject><subject>Myocardial Infarction - diagnostic imaging</subject><subject>Myocardial Infarction - physiopathology</subject><subject>NUCLEAR MEDICINE</subject><subject>NUCLEI</subject><subject>ODD-EVEN NUCLEI</subject><subject>ORGANS</subject><subject>PATIENTS</subject><subject>PROCESSING</subject><subject>RADIOISOTOPES</subject><subject>RADIOLOGY</subject><subject>RADIOLOGY AND NUCLEAR MEDICINE</subject><subject>Sympathetic Nervous System - physiopathology</subject><subject>Thallium Radioisotopes</subject><subject>TOMOGRAPHY</subject><subject>Tomography, Emission-Computed</subject><subject>Ventricular Function, Left</subject><issn>0002-9149</issn><issn>1879-1913</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUuLFTEQhYMo452r_0ChERx00ZpHv7IRZPAxMCCIzjZUJ9U9ke7kmqSF68a_bnr6oq5cJCHUd05Spwh5wugrRlnzmlLKS8kq-UKyl5LWNS9v7pEd61pZMsnEfbL7gzwk5zF-y1fG6uaMnDEpadvVO_LrM47WO5gKDcFY0AWYgA7DaHUxLE6nXC2WaN1YXJWMi2LGBKX1xvfofh6ncQFnjXVYJD_7McDhNivtDOMqgSFhKEAvCYv56Lc3psK6AcKd9SPyYIAp4uPTuSdf37_7cvmxvP704ery7XWpBZep5F0_YNdh39JetsJwqmnFGYVOclMJ04MUjWlYxQ0awLo1Qvcw1FRzyRtsxZ4823x9TFZFbRPqW-2dQ51U3UkhG56hiw06BP99wZjUbKPGaQKHfomqo5UQMq89qTZQBx9jwEEdQm45HBWjah2OWpNXa_J5U3fDUTdZ9vTkv_Qzmr-ibRq5_vxUh6hhGgI4beM_WMNExZvMvdk4zIn9sBjWhtBpNDas_Rhv__-R31b8rUw</recordid><startdate>19910201</startdate><enddate>19910201</enddate><creator>McGhie, A.Iain</creator><creator>Corbett, James R.</creator><creator>Akers, Marvin S.</creator><creator>Kulkarni, Padmakur</creator><creator>Sills, Michael N.</creator><creator>Kremers, Mark</creator><creator>Buja, L.Maximilian</creator><creator>Durant-Reville, Marc</creator><creator>Parkey, Robert W.</creator><creator>Willerson, James T.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>19910201</creationdate><title>Regional cardiac adrenergic function using I-123 meta-iodobenzylguanidine tomographic imaging after acute myocardial infarction</title><author>McGhie, A.Iain ; Corbett, James R. ; Akers, Marvin S. ; Kulkarni, Padmakur ; Sills, Michael N. ; Kremers, Mark ; Buja, L.Maximilian ; Durant-Reville, Marc ; Parkey, Robert W. ; Willerson, James T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c329t-28bfe88eb70b973d20c04210a892d43dba936d6142dedae57d3cbaf50c2926e73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>3-Iodobenzylguanidine</topic><topic>550601 - Medicine- Unsealed Radionuclides in Diagnostics</topic><topic>Adult</topic><topic>Aged</topic><topic>Arrhythmias, Cardiac - complications</topic><topic>BETA DECAY RADIOISOTOPES</topic><topic>Biological and medical sciences</topic><topic>BIOMEDICAL RADIOGRAPHY</topic><topic>BODY</topic><topic>Cardiology. Vascular system</topic><topic>CARDIOVASCULAR DISEASES</topic><topic>CARDIOVASCULAR SYSTEM</topic><topic>Catecholamines - blood</topic><topic>COMPUTERIZED TOMOGRAPHY</topic><topic>Contrast Media</topic><topic>Coronary heart disease</topic><topic>DIAGNOSIS</topic><topic>DIAGNOSTIC TECHNIQUES</topic><topic>DISEASES</topic><topic>ELECTRON CAPTURE RADIOISOTOPES</topic><topic>EMISSION COMPUTED TOMOGRAPHY</topic><topic>Female</topic><topic>HEART</topic><topic>HOURS LIVING RADIOISOTOPES</topic><topic>Humans</topic><topic>IMAGE PROCESSING</topic><topic>INTERMEDIATE MASS NUCLEI</topic><topic>IODINE 123</topic><topic>IODINE ISOTOPES</topic><topic>Iodine Radioisotopes</topic><topic>Iodobenzenes</topic><topic>ISOTOPES</topic><topic>Male</topic><topic>Medical sciences</topic><topic>MEDICINE</topic><topic>Middle Aged</topic><topic>MYOCARDIAL INFARCTION</topic><topic>Myocardial Infarction - complications</topic><topic>Myocardial Infarction - diagnostic imaging</topic><topic>Myocardial Infarction - physiopathology</topic><topic>NUCLEAR MEDICINE</topic><topic>NUCLEI</topic><topic>ODD-EVEN NUCLEI</topic><topic>ORGANS</topic><topic>PATIENTS</topic><topic>PROCESSING</topic><topic>RADIOISOTOPES</topic><topic>RADIOLOGY</topic><topic>RADIOLOGY AND NUCLEAR MEDICINE</topic><topic>Sympathetic Nervous System - physiopathology</topic><topic>Thallium Radioisotopes</topic><topic>TOMOGRAPHY</topic><topic>Tomography, Emission-Computed</topic><topic>Ventricular Function, Left</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>McGhie, A.Iain</creatorcontrib><creatorcontrib>Corbett, James R.</creatorcontrib><creatorcontrib>Akers, Marvin S.</creatorcontrib><creatorcontrib>Kulkarni, Padmakur</creatorcontrib><creatorcontrib>Sills, Michael N.</creatorcontrib><creatorcontrib>Kremers, Mark</creatorcontrib><creatorcontrib>Buja, L.Maximilian</creatorcontrib><creatorcontrib>Durant-Reville, Marc</creatorcontrib><creatorcontrib>Parkey, Robert W.</creatorcontrib><creatorcontrib>Willerson, James T.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>The American journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>McGhie, A.Iain</au><au>Corbett, James R.</au><au>Akers, Marvin S.</au><au>Kulkarni, Padmakur</au><au>Sills, Michael N.</au><au>Kremers, Mark</au><au>Buja, L.Maximilian</au><au>Durant-Reville, Marc</au><au>Parkey, Robert W.</au><au>Willerson, James T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Regional cardiac adrenergic function using I-123 meta-iodobenzylguanidine tomographic imaging after acute myocardial infarction</atitle><jtitle>The American journal of cardiology</jtitle><addtitle>Am J Cardiol</addtitle><date>1991-02-01</date><risdate>1991</risdate><volume>67</volume><issue>4</issue><spage>236</spage><epage>242</epage><pages>236-242</pages><issn>0002-9149</issn><eissn>1879-1913</eissn><coden>AJCDAG</coden><abstract>The effect of acute myocardial infarction (AMI) on regional cardiac adrenergic function was studied in 27 patients mean ± standard deviation 10 ± 4 days after AMI. Regional adrenergk function was evaluated noninvasively with I-123 meta-iodobenzylguanidine (MIBG) using a dedicated 3-detector tomograph. Four hours after its administration, there was reduced MIBG uptake in the region of infarction, 0.38 ± 0.31 counts/pixel/mCi × 103 compared with 0.60 ± 0.30 counts/pixel/mCi × 103 and 0.92 ± 0.35 counts/pixel/mCi × 103 in the zones bordering and distant from the infarct area, respectively, p < 0.001. In all patients, the area of reduced MIBG uptake after 4 hours was more extensive than the associated thallium-201 perfusion defect with defect scores of 52 ± 22 and 23 ± 18%, respectively, p < 0.001. After anterior wall AMI, the 4-hour MIBG defect score was 70 ± 13% and the degree of mismatch between myocardial perfusion and MIBG uptake was 30 ± 9% compared with 39 ± 17 and 21 ± 17% after inferior AMI, p < 0.001 and p = 0.016, respectively. The 4-hour MIBG defect score correlated inversely with the predischarge left ventricular ejection fraction, r = −0.73, p < 0.001. Patients with ventricular arrhythmia of ≥1 ventricular premature complexes per hour, paired ventricular premature complexes or ventricular tachycardia detected during the late hospital phase had higher 4-hour MIBG defect scores, 62.5 ± 15.0%, than patients with no detectable complex ventricular ectopic activity and a ventricular premature complex frequency of <1 per hour, 44.6 ± 23.4%, p = 0.036. These data suggest that after acute AMI in humans (1) the abnormality in adrenergic function is more extensive than the associated abnormality in myocardial perfusion; (2) anterior wall AMI is associated with greater disruption of cardiac adrenergic function than other infarcts; (3) the severity of cardiac adrenergic dysfunction correlates with the degree of left ventricular dysfunction; and (4) the abnormality in regional adrenergic function may be associated with the presence of ventricular ectopic activity after AMI.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>1990785</pmid><doi>10.1016/0002-9149(91)90552-V</doi><tpages>7</tpages></addata></record> |
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| ispartof | The American journal of cardiology, 1991-02, Vol.67 (4), p.236-242 |
| issn | 0002-9149 1879-1913 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | 3-Iodobenzylguanidine 550601 - Medicine- Unsealed Radionuclides in Diagnostics Adult Aged Arrhythmias, Cardiac - complications BETA DECAY RADIOISOTOPES Biological and medical sciences BIOMEDICAL RADIOGRAPHY BODY Cardiology. Vascular system CARDIOVASCULAR DISEASES CARDIOVASCULAR SYSTEM Catecholamines - blood COMPUTERIZED TOMOGRAPHY Contrast Media Coronary heart disease DIAGNOSIS DIAGNOSTIC TECHNIQUES DISEASES ELECTRON CAPTURE RADIOISOTOPES EMISSION COMPUTED TOMOGRAPHY Female HEART HOURS LIVING RADIOISOTOPES Humans IMAGE PROCESSING INTERMEDIATE MASS NUCLEI IODINE 123 IODINE ISOTOPES Iodine Radioisotopes Iodobenzenes ISOTOPES Male Medical sciences MEDICINE Middle Aged MYOCARDIAL INFARCTION Myocardial Infarction - complications Myocardial Infarction - diagnostic imaging Myocardial Infarction - physiopathology NUCLEAR MEDICINE NUCLEI ODD-EVEN NUCLEI ORGANS PATIENTS PROCESSING RADIOISOTOPES RADIOLOGY RADIOLOGY AND NUCLEAR MEDICINE Sympathetic Nervous System - physiopathology Thallium Radioisotopes TOMOGRAPHY Tomography, Emission-Computed Ventricular Function, Left |
| title | Regional cardiac adrenergic function using I-123 meta-iodobenzylguanidine tomographic imaging after acute myocardial infarction |
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