Identification of the Hepatocyte Growth Factor Receptor as the c-met Proto-Oncogene Product

Hepatocyte growth factor (HGF) is a plasminogen-like protein thought to be a humoral mediator of liver regeneration. A 145-kilodalton tyrosyl phosphoprotein observed in rapid response to HGF treatment of intact target cells was identified by immunoblot analysis as the β subunit of the c-met proto-on...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1991-02, Vol.251 (4995), p.802-804
Hauptverfasser:	Bottaro, Donald P., Rubin, Jeffrey S., Faletto, Donna L., Andrew M.-L. Chan, Kmiecik, Thomas E., George F. Vande Woude, Aaronson, Stuart A.
Format:	Artikel
Sprache:	eng
Schlagworte:	550201 - Biochemistry- Tracer Techniques Amino acids ANIMAL CELLS Antibodies BASIC BIOLOGICAL SCIENCES BETA DECAY RADIOISOTOPES BIOASSAY Biological and medical sciences BIOLOGICAL RECOVERY BIOLOGICAL REGENERATION c-met Cell Line Cell lines Cell receptors Cell structures and functions Cellular immunity CHEMICAL REACTIONS CROSS-LINKING Cross-Linking Reagents DAYS LIVING RADIOISOTOPES ELECTRON CAPTURE RADIOISOTOPES Fundamental and applied biological sciences. Psychology GENES Growth factor receptors GROWTH FACTORS Growth Substances - metabolism Growth Substances - physiology Hepatocyte Growth Factor Hepatocytes Hormone receptors. Growth factor receptors. Cytokine receptors. Prostaglandin receptors Humans IMMUNOASSAY Immunoprecipitation INTERMEDIATE MASS NUCLEI INTERNAL CONVERSION RADIOISOTOPES IODINE 125 IODINE ISOTOPES ISOTOPE APPLICATIONS ISOTOPES LIGANDS LIVER CELLS MEMBRANE PROTEINS Met protein MITOGENS Molecular and cellular biology Molecular Weight NUCLEI ODD-EVEN NUCLEI ONCOGENES ORGANIC COMPOUNDS Phosphorylation POLYMERIZATION Precipitin Tests protein-tyrosine kinase Protein-Tyrosine Kinases - metabolism PROTEINS Proto oncogenes Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-met RADIOISOTOPES RECEPTORS Receptors, Cell Surface - metabolism RECOVERY SOMATIC CELLS TRACER TECHNIQUES
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