Measurement of retinoid effects on epidermal renewal
Retinoids have become important therapeutic tools. They are used to treat a wide array of skin diseases such as acne, ichthyosis, and photoaging. Changes in epidermal turnover always accompany the therapeutic use of retinoids, irrespective of the pathogenesis of the disease being treated or the bioc...
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| Veröffentlicht in: | Methods in Enzymology 1990, Vol.190, p.76-81 |
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| description | Retinoids have become important therapeutic tools. They are used to treat a wide array of skin diseases such as acne, ichthyosis, and photoaging. Changes in epidermal turnover always accompany the therapeutic use of retinoids, irrespective of the pathogenesis of the disease being treated or the biochemical mechanism(s) by which the retinoids produce their therapeutic effect. This chapter describes methods for measuring epidermal turnover. Epidermal turnover is continuous and spatially oriented. Renewal or turnover occurs to replace the most highly differenced keratinocytes (squames) that separate (desquamate) from the outermost layer of the epidermis (stratum corneum). The general principles of renewal as well as the measurements made to quantitate renewal are equally applicable to human epidermis, the epidermis of commonly used experimental animals, and cultivated human keratinocytes. Three parameters are most often measured to assess epidermal renewal: proliferation, transit time, and horn production or desquamation. |
| doi_str_mv | 10.1016/0076-6879(90)90011-O |
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They are used to treat a wide array of skin diseases such as acne, ichthyosis, and photoaging. Changes in epidermal turnover always accompany the therapeutic use of retinoids, irrespective of the pathogenesis of the disease being treated or the biochemical mechanism(s) by which the retinoids produce their therapeutic effect. This chapter describes methods for measuring epidermal turnover. Epidermal turnover is continuous and spatially oriented. Renewal or turnover occurs to replace the most highly differenced keratinocytes (squames) that separate (desquamate) from the outermost layer of the epidermis (stratum corneum). The general principles of renewal as well as the measurements made to quantitate renewal are equally applicable to human epidermis, the epidermis of commonly used experimental animals, and cultivated human keratinocytes. Three parameters are most often measured to assess epidermal renewal: proliferation, transit time, and horn production or desquamation.</description><identifier>ISSN: 0076-6879</identifier><identifier>ISBN: 0121820912</identifier><identifier>ISBN: 9780121820916</identifier><identifier>EISSN: 1557-7988</identifier><identifier>DOI: 10.1016/0076-6879(90)90011-O</identifier><identifier>PMID: 2087197</identifier><identifier>CODEN: MENZAU</identifier><language>eng</language><publisher>San Diego, CA: Elsevier Science & Technology</publisher><subject>550201 - Biochemistry- Tracer Techniques ; AMINO ACIDS ; ANIMAL TISSUES ; ANIMALS ; AZINES ; BASIC BIOLOGICAL SCIENCES ; Biological and medical sciences ; BIOLOGICAL EFFECTS ; BODY ; CARBOXYLIC ACID ESTERS ; CARBOXYLIC ACIDS ; Cell cycle, cell proliferation ; CELL DIVISION ; Cell Division - drug effects ; Cell Movement - drug effects ; Cell physiology ; Cells, Cultured ; DNA REPLICATION ; DNA Replication - drug effects ; Epidermal Cells ; EPIDERMIS ; Epidermis - drug effects ; Epidermis - physiology ; Epithelial Cells ; EPITHELIUM ; Epithelium - drug effects ; Epithelium - physiology ; ESTERS ; Fundamental and applied biological sciences. Psychology ; GLYCINE ; Glycine - metabolism ; HETEROCYCLIC COMPOUNDS ; Humans ; HYDROGEN COMPOUNDS ; ISOTOPE APPLICATIONS ; ISOTOPE DILUTION ; Keratinocytes - cytology ; MAMMALS ; MAN ; Molecular and cellular biology ; NUCLEIC ACID REPLICATION ; NUCLEOSIDES ; NUCLEOTIDES ; ORGANIC ACIDS ; ORGANIC COMPOUNDS ; ORGANIC NITROGEN COMPOUNDS ; ORGANS ; PRIMATES ; PYRIMIDINES ; Radioisotope Dilution Technique ; RETINOIC ACID ; Retinoids - pharmacology ; RIBOSIDES ; SKIN ; THYMIDINE ; Thymidine - metabolism ; TISSUES ; TRACER TECHNIQUES ; Tretinoin - pharmacology ; Tritium ; TRITIUM COMPOUNDS ; VERTEBRATES</subject><ispartof>Methods in Enzymology, 1990, Vol.190, p.76-81</ispartof><rights>1990</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0076-6879(90)90011-O$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,315,780,781,785,794,886,3460,3551,4025,11292,27927,27928,27929,45814,45999</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19575252$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2087197$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/5736759$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Milstone, Leonard M.</creatorcontrib><title>Measurement of retinoid effects on epidermal renewal</title><title>Methods in Enzymology</title><addtitle>Methods Enzymol</addtitle><description>Retinoids have become important therapeutic tools. They are used to treat a wide array of skin diseases such as acne, ichthyosis, and photoaging. Changes in epidermal turnover always accompany the therapeutic use of retinoids, irrespective of the pathogenesis of the disease being treated or the biochemical mechanism(s) by which the retinoids produce their therapeutic effect. This chapter describes methods for measuring epidermal turnover. Epidermal turnover is continuous and spatially oriented. Renewal or turnover occurs to replace the most highly differenced keratinocytes (squames) that separate (desquamate) from the outermost layer of the epidermis (stratum corneum). The general principles of renewal as well as the measurements made to quantitate renewal are equally applicable to human epidermis, the epidermis of commonly used experimental animals, and cultivated human keratinocytes. Three parameters are most often measured to assess epidermal renewal: proliferation, transit time, and horn production or desquamation.</description><subject>550201 - Biochemistry- Tracer Techniques</subject><subject>AMINO ACIDS</subject><subject>ANIMAL TISSUES</subject><subject>ANIMALS</subject><subject>AZINES</subject><subject>BASIC BIOLOGICAL SCIENCES</subject><subject>Biological and medical sciences</subject><subject>BIOLOGICAL EFFECTS</subject><subject>BODY</subject><subject>CARBOXYLIC ACID ESTERS</subject><subject>CARBOXYLIC ACIDS</subject><subject>Cell cycle, cell proliferation</subject><subject>CELL DIVISION</subject><subject>Cell Division - drug effects</subject><subject>Cell Movement - drug effects</subject><subject>Cell physiology</subject><subject>Cells, Cultured</subject><subject>DNA REPLICATION</subject><subject>DNA Replication - drug effects</subject><subject>Epidermal Cells</subject><subject>EPIDERMIS</subject><subject>Epidermis - drug effects</subject><subject>Epidermis - physiology</subject><subject>Epithelial Cells</subject><subject>EPITHELIUM</subject><subject>Epithelium - drug effects</subject><subject>Epithelium - physiology</subject><subject>ESTERS</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>GLYCINE</subject><subject>Glycine - metabolism</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>Humans</subject><subject>HYDROGEN COMPOUNDS</subject><subject>ISOTOPE APPLICATIONS</subject><subject>ISOTOPE DILUTION</subject><subject>Keratinocytes - cytology</subject><subject>MAMMALS</subject><subject>MAN</subject><subject>Molecular and cellular biology</subject><subject>NUCLEIC ACID REPLICATION</subject><subject>NUCLEOSIDES</subject><subject>NUCLEOTIDES</subject><subject>ORGANIC ACIDS</subject><subject>ORGANIC COMPOUNDS</subject><subject>ORGANIC NITROGEN COMPOUNDS</subject><subject>ORGANS</subject><subject>PRIMATES</subject><subject>PYRIMIDINES</subject><subject>Radioisotope Dilution Technique</subject><subject>RETINOIC ACID</subject><subject>Retinoids - pharmacology</subject><subject>RIBOSIDES</subject><subject>SKIN</subject><subject>THYMIDINE</subject><subject>Thymidine - metabolism</subject><subject>TISSUES</subject><subject>TRACER TECHNIQUES</subject><subject>Tretinoin - pharmacology</subject><subject>Tritium</subject><subject>TRITIUM COMPOUNDS</subject><subject>VERTEBRATES</subject><issn>0076-6879</issn><issn>1557-7988</issn><isbn>0121820912</isbn><isbn>9780121820916</isbn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kU1r3DAQhkWbkm62-QcNmEBCenA7ki1LugRCyBds2Ut7FrI0piq2vJHslP77yNklc9HhfRDvzEPIVwrfKdDmB4BoykYKdaXgmwKgtNx-ICvKuSiFkvIjOQHKqGSgKDsiq3f-MzlN6S_k4U1TQXVMjhlIQZVYkfonmjRHHDBMxdgVEScfRu8K7Dq0UyrGUODOO4yD6XMa8J_pv5BPnekTnh7eNfl9f_fr9rHcbB-ebm82JVZUTiUyq4RhVlpshWItk9ZaoYywuVRLoUHm6hbR1gqBMUCOjnFUTBiDrnXVmpzv_x3T5HWyfkL7x44h5Gaai6oRXGXocg_t4vg8Y5r04JPFvjcBxzlpCRWDuqYZPDuAczug07voBxP_68Mtcn5xyE2ypu-iCdand4wqLjjjLHPXew7z6i8e49IMg0Xn41LMjV5T0IszvTjQiwOtQL8509vqFdVwhLk</recordid><startdate>1990</startdate><enddate>1990</enddate><creator>Milstone, Leonard M.</creator><general>Elsevier Science & Technology</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>1990</creationdate><title>Measurement of retinoid effects on epidermal renewal</title><author>Milstone, Leonard M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e318t-e2c97a2c8ceb792b28ccc79a7c879b106e2d4beec49e0220e5ed25e927aaedbd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>550201 - Biochemistry- Tracer Techniques</topic><topic>AMINO ACIDS</topic><topic>ANIMAL TISSUES</topic><topic>ANIMALS</topic><topic>AZINES</topic><topic>BASIC BIOLOGICAL SCIENCES</topic><topic>Biological and medical sciences</topic><topic>BIOLOGICAL EFFECTS</topic><topic>BODY</topic><topic>CARBOXYLIC ACID ESTERS</topic><topic>CARBOXYLIC ACIDS</topic><topic>Cell cycle, cell proliferation</topic><topic>CELL DIVISION</topic><topic>Cell Division - drug effects</topic><topic>Cell Movement - drug effects</topic><topic>Cell physiology</topic><topic>Cells, Cultured</topic><topic>DNA REPLICATION</topic><topic>DNA Replication - drug effects</topic><topic>Epidermal Cells</topic><topic>EPIDERMIS</topic><topic>Epidermis - drug effects</topic><topic>Epidermis - physiology</topic><topic>Epithelial Cells</topic><topic>EPITHELIUM</topic><topic>Epithelium - drug effects</topic><topic>Epithelium - physiology</topic><topic>ESTERS</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>GLYCINE</topic><topic>Glycine - metabolism</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>Humans</topic><topic>HYDROGEN COMPOUNDS</topic><topic>ISOTOPE APPLICATIONS</topic><topic>ISOTOPE DILUTION</topic><topic>Keratinocytes - cytology</topic><topic>MAMMALS</topic><topic>MAN</topic><topic>Molecular and cellular biology</topic><topic>NUCLEIC ACID REPLICATION</topic><topic>NUCLEOSIDES</topic><topic>NUCLEOTIDES</topic><topic>ORGANIC ACIDS</topic><topic>ORGANIC COMPOUNDS</topic><topic>ORGANIC NITROGEN COMPOUNDS</topic><topic>ORGANS</topic><topic>PRIMATES</topic><topic>PYRIMIDINES</topic><topic>Radioisotope Dilution Technique</topic><topic>RETINOIC ACID</topic><topic>Retinoids - pharmacology</topic><topic>RIBOSIDES</topic><topic>SKIN</topic><topic>THYMIDINE</topic><topic>Thymidine - metabolism</topic><topic>TISSUES</topic><topic>TRACER TECHNIQUES</topic><topic>Tretinoin - pharmacology</topic><topic>Tritium</topic><topic>TRITIUM COMPOUNDS</topic><topic>VERTEBRATES</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Milstone, Leonard M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>Methods in Enzymology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Milstone, Leonard M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Measurement of retinoid effects on epidermal renewal</atitle><jtitle>Methods in Enzymology</jtitle><addtitle>Methods Enzymol</addtitle><date>1990</date><risdate>1990</risdate><volume>190</volume><spage>76</spage><epage>81</epage><pages>76-81</pages><issn>0076-6879</issn><eissn>1557-7988</eissn><isbn>0121820912</isbn><isbn>9780121820916</isbn><coden>MENZAU</coden><abstract>Retinoids have become important therapeutic tools. They are used to treat a wide array of skin diseases such as acne, ichthyosis, and photoaging. Changes in epidermal turnover always accompany the therapeutic use of retinoids, irrespective of the pathogenesis of the disease being treated or the biochemical mechanism(s) by which the retinoids produce their therapeutic effect. This chapter describes methods for measuring epidermal turnover. Epidermal turnover is continuous and spatially oriented. Renewal or turnover occurs to replace the most highly differenced keratinocytes (squames) that separate (desquamate) from the outermost layer of the epidermis (stratum corneum). The general principles of renewal as well as the measurements made to quantitate renewal are equally applicable to human epidermis, the epidermis of commonly used experimental animals, and cultivated human keratinocytes. Three parameters are most often measured to assess epidermal renewal: proliferation, transit time, and horn production or desquamation.</abstract><cop>San Diego, CA</cop><pub>Elsevier Science & Technology</pub><pmid>2087197</pmid><doi>10.1016/0076-6879(90)90011-O</doi><tpages>6</tpages></addata></record> |
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| ispartof | Methods in Enzymology, 1990, Vol.190, p.76-81 |
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| subjects | 550201 - Biochemistry- Tracer Techniques AMINO ACIDS ANIMAL TISSUES ANIMALS AZINES BASIC BIOLOGICAL SCIENCES Biological and medical sciences BIOLOGICAL EFFECTS BODY CARBOXYLIC ACID ESTERS CARBOXYLIC ACIDS Cell cycle, cell proliferation CELL DIVISION Cell Division - drug effects Cell Movement - drug effects Cell physiology Cells, Cultured DNA REPLICATION DNA Replication - drug effects Epidermal Cells EPIDERMIS Epidermis - drug effects Epidermis - physiology Epithelial Cells EPITHELIUM Epithelium - drug effects Epithelium - physiology ESTERS Fundamental and applied biological sciences. Psychology GLYCINE Glycine - metabolism HETEROCYCLIC COMPOUNDS Humans HYDROGEN COMPOUNDS ISOTOPE APPLICATIONS ISOTOPE DILUTION Keratinocytes - cytology MAMMALS MAN Molecular and cellular biology NUCLEIC ACID REPLICATION NUCLEOSIDES NUCLEOTIDES ORGANIC ACIDS ORGANIC COMPOUNDS ORGANIC NITROGEN COMPOUNDS ORGANS PRIMATES PYRIMIDINES Radioisotope Dilution Technique RETINOIC ACID Retinoids - pharmacology RIBOSIDES SKIN THYMIDINE Thymidine - metabolism TISSUES TRACER TECHNIQUES Tretinoin - pharmacology Tritium TRITIUM COMPOUNDS VERTEBRATES |
| title | Measurement of retinoid effects on epidermal renewal |
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