Cysteine-rich intestinal protein binds zinc during transmucosal zinc transport

The mechanism of zinc absorption has not been delineated, but kinetic studies show that both passive and carrier-mediated processes are involved. We have identified a low molecular mass zinc-binding protein in the soluble fraction of rat intestinal mucosa that could function as an intracellular zinc...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1991-11, Vol.88 (21), p.9671-9674
Hauptverfasser:	Hempe, J.M. (University of Florida, Gainesville, FL), Cousins, R.J
Format:	Artikel
Sprache:	eng
Schlagworte:	550201 - Biochemistry- Tracer Techniques ABSORCION DIGESTIVA ABSORPTION ABSORPTION DIGESTIVE AMINO ACID SEQUENCE AMINO ACIDS ANIMALS BASIC BIOLOGICAL SCIENCES BEBES BETA DECAY RADIOISOTOPES BETA-PLUS DECAY RADIOISOTOPES BLOOD VESSELS Blotting, Western BODY CARBOXYLIC ACIDS CARDIOVASCULAR SYSTEM CARENCE EN OLIGOELEMENT Carrier Proteins - chemistry Carrier Proteins - immunology Carrier Proteins - metabolism CINC CISTEINA CYSTEINE cysteine-rich intestinal protein Cytosol DAYS LIVING RADIOISOTOPES DEFICIENCIA DE OLIGOELEMENTOS DIET DIGESTIVE SYSTEM ELECTRON CAPTURE RADIOISOTOPES ELECTROPHORESIS ENDOCRINE GLANDS ENFANT EN BAS AGE EVEN-ODD NUCLEI FISIOLOGIA VEGETAL GASTROINTESTINAL TRACT Gene expression regulation GLANDS INTERMEDIATE MASS NUCLEI INTESTINAL ABSORPTION Intestinal mucosa Intestinal Mucosa - metabolism INTESTINES INVESTIGACION ISOTOPES LIM Domain Proteins LIVER MAMMALS MEMBRANE TRANSPORT MEMBRANES Messenger RNA METALLOPROTEINS Metalloproteins - chemistry Metalloproteins - immunology Metalloproteins - metabolism METALLOTHIONEIN Molecular Sequence Data MOLECULAR STRUCTURE MUCOUS MEMBRANES NUCLEI NUTRICION HUMANA NUTRITION HUMAINE ORGANIC ACIDS ORGANIC COMPOUNDS ORGANIC SULFUR COMPOUNDS ORGANS PANCREAS PHYSIOLOGIE VEGETALE PORTAL SYSTEM PROTEINAS PROTEINE PROTEINS RADIOISOTOPES RAT RATA RATS Rats, Inbred Strains RECHERCHE RODENTS Sequence Alignment Small intestine THIOLS UPTAKE VEINS VERTEBRATES ZINC Zinc - metabolism ZINC 65 ZINC ISOTOPES
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