Evidence that nitric oxide modulates food intake in mice
Nitric oxide (NO) may be an intercellular modulator within the central nervous system. L-arginine, which results in NO synthesis, increased food intake in mice while the inhibitor of NO synthesis, L-N G -nitro arginine (L-NO Arg) inhibited food intake in food deprived mice. L-arginine, but not D-arg...
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| Veröffentlicht in: | Life sciences (1973) 1991, Vol.49 (10), p.707-711 |
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| container_title | Life sciences (1973) |
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| creator | Morley, John E. Flood, James F. |
| description | Nitric oxide (NO) may be an intercellular modulator within the central nervous system. L-arginine, which results in NO synthesis, increased food intake in mice while the inhibitor of NO synthesis, L-N
G -nitro arginine (L-NO Arg) inhibited food intake in food deprived mice. L-arginine, but not D-arginine, partially reversed the inhibitory effect of L-NO Arg on food intake. These findings suggest the possibility that NO may be a physiological modulator of food intake and that the possibility of exploring the utility of L-NO arg in the treatment of obesity should be explored. |
| doi_str_mv | 10.1016/0024-3205(91)90102-H |
| format | Article |
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G -nitro arginine (L-NO Arg) inhibited food intake in food deprived mice. L-arginine, but not D-arginine, partially reversed the inhibitory effect of L-NO Arg on food intake. These findings suggest the possibility that NO may be a physiological modulator of food intake and that the possibility of exploring the utility of L-NO arg in the treatment of obesity should be explored.</description><identifier>ISSN: 0024-3205</identifier><identifier>EISSN: 1879-0631</identifier><identifier>DOI: 10.1016/0024-3205(91)90102-H</identifier><identifier>PMID: 1875780</identifier><identifier>CODEN: LIFSAK</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>560300 - Chemicals Metabolism & Toxicology ; ADIPOSE TISSUE ; ANIMAL TISSUES ; ANIMALS ; APETITO ; APPETIT ; ARGININA ; ARGININE ; Arginine - physiology ; Biological and medical sciences ; BIOLOGICAL EFFECTS ; BODY ; CHALCOGENIDES ; CONNECTIVE TISSUE ; Feeding Behavior - drug effects ; Feeding. Feeding behavior ; FOOD ; Fundamental and applied biological sciences. Psychology ; INGESTION DE ALIMENTOS ; INTAKE ; Male ; MAMMALS ; METABOLISM ; MICE ; NITRIC OXIDE ; Nitric Oxide - metabolism ; NITROGEN COMPOUNDS ; NITROGEN OXIDES ; OXIDES ; OXIDOS DE NITROGENO ; OXYDE D'AZOTE ; OXYGEN COMPOUNDS ; PRISE ALIMENTAIRE ; RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT ; RATON ; RODENTS ; SISTEMA NERVIOSO CENTRAL ; SOURIS ; Stereoisomerism ; SYSTEME NERVEUX CENTRAL ; TISSUES ; VERTEBRATES ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>Life sciences (1973), 1991, Vol.49 (10), p.707-711</ispartof><rights>1991</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c463t-98cc4cd9e37acc209cc0e76b6060f9a41624e56fa51fd169267a6e0af9d68f323</citedby><cites>FETCH-LOGICAL-c463t-98cc4cd9e37acc209cc0e76b6060f9a41624e56fa51fd169267a6e0af9d68f323</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0024-3205(91)90102-H$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,777,781,882,3537,4010,27904,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4961335$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1875780$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/5695435$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Morley, John E.</creatorcontrib><creatorcontrib>Flood, James F.</creatorcontrib><title>Evidence that nitric oxide modulates food intake in mice</title><title>Life sciences (1973)</title><addtitle>Life Sci</addtitle><description>Nitric oxide (NO) may be an intercellular modulator within the central nervous system. L-arginine, which results in NO synthesis, increased food intake in mice while the inhibitor of NO synthesis, L-N
G -nitro arginine (L-NO Arg) inhibited food intake in food deprived mice. L-arginine, but not D-arginine, partially reversed the inhibitory effect of L-NO Arg on food intake. These findings suggest the possibility that NO may be a physiological modulator of food intake and that the possibility of exploring the utility of L-NO arg in the treatment of obesity should be explored.</description><subject>560300 - Chemicals Metabolism & Toxicology</subject><subject>ADIPOSE TISSUE</subject><subject>ANIMAL TISSUES</subject><subject>ANIMALS</subject><subject>APETITO</subject><subject>APPETIT</subject><subject>ARGININA</subject><subject>ARGININE</subject><subject>Arginine - physiology</subject><subject>Biological and medical sciences</subject><subject>BIOLOGICAL EFFECTS</subject><subject>BODY</subject><subject>CHALCOGENIDES</subject><subject>CONNECTIVE TISSUE</subject><subject>Feeding Behavior - drug effects</subject><subject>Feeding. Feeding behavior</subject><subject>FOOD</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>INGESTION DE ALIMENTOS</subject><subject>INTAKE</subject><subject>Male</subject><subject>MAMMALS</subject><subject>METABOLISM</subject><subject>MICE</subject><subject>NITRIC OXIDE</subject><subject>Nitric Oxide - metabolism</subject><subject>NITROGEN COMPOUNDS</subject><subject>NITROGEN OXIDES</subject><subject>OXIDES</subject><subject>OXIDOS DE NITROGENO</subject><subject>OXYDE D'AZOTE</subject><subject>OXYGEN COMPOUNDS</subject><subject>PRISE ALIMENTAIRE</subject><subject>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</subject><subject>RATON</subject><subject>RODENTS</subject><subject>SISTEMA NERVIOSO CENTRAL</subject><subject>SOURIS</subject><subject>Stereoisomerism</subject><subject>SYSTEME NERVEUX CENTRAL</subject><subject>TISSUES</subject><subject>VERTEBRATES</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0024-3205</issn><issn>1879-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFrFTEQx4Mo9Vn9AqKwiIgeVifJJru5CFKqTyh40J5DOjux0X2bNskr-u3Ndh_1pqeB_H8zzPzC2DMObzlw_Q5AdK0UoF4b_sYAB9Fu77ENH3rTgpb8PtvcIQ_Zo5x_AIBSvTxiRxVS_QAbNpzehJFmpKZcutLMoaSATfxVH5tdHPeTK5QbH-PYhLm4n1RLswtIj9kD76ZMTw71mJ1_PP12sm3Pvnz6fPLhrMVOy9KaAbHD0ZDsHaIAgwjU6wsNGrxxHdeiI6W9U9yPXBuhe6cJnDejHrwU8pi9WOfGXILNGArhJcZ5JixWaaM6qSr0aoWuUrzeUy52FzLSNLmZ4j7bXkA3SDH8F-S6Lmb6voLdCmKKOSfy9iqFnUu_LQe76LeLW7u4tYbbW_12W9ueH-bvL3Y0_m1afdf85SF3Gd3kk5sx5DusM5rL23uerph30brvqSLnXw1XWkhTw_drSFX7TaC0WFm-cAxpkTLG8O8l_wBYo6a4</recordid><startdate>1991</startdate><enddate>1991</enddate><creator>Morley, John E.</creator><creator>Flood, James F.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>1991</creationdate><title>Evidence that nitric oxide modulates food intake in mice</title><author>Morley, John E. ; Flood, James F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c463t-98cc4cd9e37acc209cc0e76b6060f9a41624e56fa51fd169267a6e0af9d68f323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>560300 - Chemicals Metabolism & Toxicology</topic><topic>ADIPOSE TISSUE</topic><topic>ANIMAL TISSUES</topic><topic>ANIMALS</topic><topic>APETITO</topic><topic>APPETIT</topic><topic>ARGININA</topic><topic>ARGININE</topic><topic>Arginine - physiology</topic><topic>Biological and medical sciences</topic><topic>BIOLOGICAL EFFECTS</topic><topic>BODY</topic><topic>CHALCOGENIDES</topic><topic>CONNECTIVE TISSUE</topic><topic>Feeding Behavior - drug effects</topic><topic>Feeding. Feeding behavior</topic><topic>FOOD</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>INGESTION DE ALIMENTOS</topic><topic>INTAKE</topic><topic>Male</topic><topic>MAMMALS</topic><topic>METABOLISM</topic><topic>MICE</topic><topic>NITRIC OXIDE</topic><topic>Nitric Oxide - metabolism</topic><topic>NITROGEN COMPOUNDS</topic><topic>NITROGEN OXIDES</topic><topic>OXIDES</topic><topic>OXIDOS DE NITROGENO</topic><topic>OXYDE D'AZOTE</topic><topic>OXYGEN COMPOUNDS</topic><topic>PRISE ALIMENTAIRE</topic><topic>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. 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L-arginine, which results in NO synthesis, increased food intake in mice while the inhibitor of NO synthesis, L-N
G -nitro arginine (L-NO Arg) inhibited food intake in food deprived mice. L-arginine, but not D-arginine, partially reversed the inhibitory effect of L-NO Arg on food intake. These findings suggest the possibility that NO may be a physiological modulator of food intake and that the possibility of exploring the utility of L-NO arg in the treatment of obesity should be explored.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>1875780</pmid><doi>10.1016/0024-3205(91)90102-H</doi><tpages>5</tpages></addata></record> |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | 560300 - Chemicals Metabolism & Toxicology ADIPOSE TISSUE ANIMAL TISSUES ANIMALS APETITO APPETIT ARGININA ARGININE Arginine - physiology Biological and medical sciences BIOLOGICAL EFFECTS BODY CHALCOGENIDES CONNECTIVE TISSUE Feeding Behavior - drug effects Feeding. Feeding behavior FOOD Fundamental and applied biological sciences. Psychology INGESTION DE ALIMENTOS INTAKE Male MAMMALS METABOLISM MICE NITRIC OXIDE Nitric Oxide - metabolism NITROGEN COMPOUNDS NITROGEN OXIDES OXIDES OXIDOS DE NITROGENO OXYDE D'AZOTE OXYGEN COMPOUNDS PRISE ALIMENTAIRE RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RATON RODENTS SISTEMA NERVIOSO CENTRAL SOURIS Stereoisomerism SYSTEME NERVEUX CENTRAL TISSUES VERTEBRATES Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Evidence that nitric oxide modulates food intake in mice |
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