Recognition of foldback DNA by the human DNA (cytosine-5-) methyltransferase

In order to specify the recognition requirements of the human DNA (cytosine-5-)-methyltransferase, two isomeric 48mers were synthesized so as to link a long block of DNA with a shorter complementary block of DNA through a tether consisting of five thymidine residues. These isomeric foldback molecule...

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Veröffentlicht in:	Biochemistry (Easton) 1992-01, Vol.31 (3), p.850-854
Hauptverfasser:	Smith, Steven S, Lingeman, Robert G, Kaplan, Bruce E
Format:	Artikel
Sprache:	eng
Schlagworte:	550201 - Biochemistry- Tracer Techniques AMINES Analytical, structural and metabolic biochemistry AUTORADIOGRAPHY AZINES Base Sequence BASIC BIOLOGICAL SCIENCES Biological and medical sciences BIOSYNTHESIS CARBON-GROUP TRANSFERASES CYTOSINE DNA DNA (Cytosine-5-)-Methyltransferases - metabolism DNA - chemistry DNA - metabolism ENZYMES Enzymes and enzyme inhibitors Female Fundamental and applied biological sciences. Psychology HETEROCYCLIC COMPOUNDS Humans ISOMERS Kinetics MATHEMATICAL MODELS METHYL TRANSFERASES Methylation Models, Molecular MOLECULAR MODELS Molecular Sequence Data Nucleic Acid Conformation NUCLEIC ACIDS ORGANIC COMPOUNDS ORGANIC NITROGEN COMPOUNDS ORGANIC OXYGEN COMPOUNDS Placenta - enzymology Pregnancy PROTEINS PYRIMIDINES Substrate Specificity SYNTHESIS TRANSFERASES
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