Cooperative mixtures of bispecific F(ab')2 antibodies for delivering saporin to lymphoma in vitro and in vivo

We report that selected combinations of two or more monoclonal bispecific F(ab')2 antibodies (BsAbs) far outperform single derivatives in the delivery of the ribosome-inactivating protein, saporin, to guinea pig L2C leukemic cells. Throughout the work, BsAbs were constructed by thioether-linkin...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1991-05, Vol.51 (9), p.2353-2361
Hauptverfasser:	FRENCH, R. R, COURTENAY, A. E, INGAMELLS, S, STEVENSON, G. T, GLENNIE, M. J
Format:	Artikel
Sprache:	eng
Schlagworte:	AMINO ACIDS ANIMAL CELLS ANIMALS ANTIBODIES Antibodies, Monoclonal - immunology Antibodies, Monoclonal - therapeutic use Antibody Affinity - immunology Antineoplastic agents Antineoplastic Agents, Phytogenic - immunology Antineoplastic Agents, Phytogenic - metabolism Antineoplastic Agents, Phytogenic - therapeutic use Biological and medical sciences CARBOXYLIC ACIDS DISEASES Drug Synergism General aspects GUINEA PIGS HYDROGEN COMPOUNDS IMMUNE SYSTEM DISEASES Immunoglobulin Fab Fragments - immunology Immunoglobulin Fab Fragments - therapeutic use IMMUNOLOGY IMMUNOTHERAPY Immunotoxins - immunology Immunotoxins - metabolism Immunotoxins - therapeutic use Iodine Radioisotopes - pharmacokinetics ISOTOPE APPLICATIONS LEUCINE Leucine - pharmacokinetics LEUKEMIA MAMMALS Medical sciences MEDICINE MICE Mice, Inbred BALB C Mice, Inbred CBA MONOCLONAL ANTIBODIES N-Glycosyl Hydrolases NEOPLASMS NUCLEAR MEDICINE ORGANIC ACIDS ORGANIC COMPOUNDS Pharmacology. Drug treatments Plant Proteins - immunology Plant Proteins - metabolism Plant Proteins - therapeutic use Precursor Cell Lymphoblastic Leukemia-Lymphoma - immunology Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy RADIOIMMUNOLOGY RADIOIMMUNOTHERAPY RADIOLOGY RADIOLOGY AND NUCLEAR MEDICINE RADIOTHERAPY Ribosome Inactivating Proteins, Type 1 RODENTS SPECIFICITY THERAPY TRACER TECHNIQUES TRITIUM COMPOUNDS TUMOR CELLS Tumor Cells, Cultured VERTEBRATES 550604 > Medicine-- Unsealed Radionuclides in Therapy-- (1980-)
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