Stereoselective inhibition of thromboxane-induced coronary vasoconstriction by 1,4-dihydropyridine calcium channel antagonists

The biological activity of the (+)‐S‐ and (−)‐R‐enantiomers of niguldipine, of the (−)‐S‐ and (+)‐R‐enantiomers of felodipine and nitrendipine, and of rac‐nisoldipine and rac‐nimodipine was investigated in vitro and in vivo. Inhibition of coronary vasoconstriction due to the thromboxane A2 (TxA2)‐mi...

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Veröffentlicht in:	Chirality (New York, N.Y.) N.Y.), 1990, Vol.2 (4), p.233-240
Hauptverfasser:	Eltze, Manfrid, Sanders, Karl H., Boss, Hildegard, Boer, Rainer, Ulrich, Wolf-Rüdiger, Flockerzi, Dieter
Format:	Artikel
Sprache:	eng
Schlagworte:	1,4‐dihydropypyridine enantiomers 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid 4-dihydropypyridine enantiomers 550201 - Biochemistry- Tracer Techniques ANIMALS ARTERIES AZINES BASIC BIOLOGICAL SCIENCES Binding, Competitive BIOCHEMICAL REACTION KINETICS BLOOD PRESSURE BLOOD VESSELS BODY calcium channel binding Calcium Channel Blockers - pharmacology Calcium Channels - drug effects Calcium Channels - metabolism CARDIOVASCULAR DISEASES CARDIOVASCULAR SYSTEM CELL CONSTITUENTS Cell Membrane - metabolism CELL MEMBRANES CORONARIES coronary vasoconstriction Dihydropyridines - metabolism Dihydropyridines - pharmacology DISEASES GUINEA PIGS HEART Heart - drug effects Heart - physiology HETEROCYCLIC COMPOUNDS HYDROGEN COMPOUNDS HYPERTENSION IN VITRO In Vitro Techniques IN VIVO INHIBITION ISOTOPE APPLICATIONS Isradipine KINETICS Male MAMMALS MEMBRANE PROTEINS MEMBRANES MUSCLES Muscles - metabolism ORGANIC COMPOUNDS ORGANIC NITROGEN COMPOUNDS ORGANS PORINS Prostaglandin Endoperoxides, Synthetic - pharmacology PROSTAGLANDINS PROTEINS PYRIDINES Pyridines - metabolism Radioligand Assay RATS Rats, Inbred SHR REACTION KINETICS RECEPTORS RODENTS Stereoisomerism stereoselectivity Structure-Activity Relationship STRUCTURE-ACTIVITY RELATIONSHIPS SYMPTOMS thromboxane A2 (TxA2) Thromboxane A2 - physiology TRACER TECHNIQUES Tritium TRITIUM COMPOUNDS VASCULAR DISEASES VASOCONSTRICTION Vasoconstriction - drug effects VERTEBRATES
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