Monoclonal antibody-based therapy of a human tumor xenograft with a 177lutetium-labeled immunoconjugate

177Lutetium (177Lu) is a member of the family of elements known as lanthanides or rare earths. Monoclonal antibody (MAb) CC49, a murine IgG1, which is reactive with the tumor-associated antigen, TAG-72, has been shown previously to react with a wide range of human carcinomas; CC49 reacts to a differ...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1991-06, Vol.51 (11), p.2889
Hauptverfasser:	Schlom, J, Siler, K, Milenic, D E, Eggensperger, D, Colcher, D, Miller, L S, Houchens, D, Cheng, R, Kaplan, D, Goeckeler, W
Format:	Artikel
Sprache:	eng
Schlagworte:	550604 - Medicine- Unsealed Radionuclides in Therapy- (1980-) ACUTE EXPOSURE ACUTE IRRADIATION Adenocarcinoma, Mucinous - pathology Adenocarcinoma, Mucinous - radiotherapy ANIMALS Antibodies, Monoclonal - immunology Antibodies, Monoclonal - therapeutic use BETA DECAY RADIOISOTOPES BETA-MINUS DECAY RADIOISOTOPES BODY CARCINOMAS Colonic Neoplasms - pathology Colonic Neoplasms - radiotherapy DAYS LIVING RADIOISOTOPES DIGESTIVE SYSTEM DISEASES DISTRIBUTION Drug Screening Assays, Antitumor EXPERIMENTAL NEOPLASMS Female FRACTIONATED IRRADIATION GASTROINTESTINAL TRACT Humans Immunoglobulin G - immunology Immunoglobulin G - therapeutic use IMMUNOLOGY IMMUNOTHERAPY INTERMEDIATE MASS NUCLEI INTESTINES IRRADIATION ISOMERIC TRANSITION ISOTOPES ISOTOPES LARGE INTESTINE Lutetium - pharmacokinetics Lutetium - therapeutic use LUTETIUM 177 LUTETIUM ISOTOPES MAMMALS MEDICINE MICE Mice, Nude NEOPLASMS NUCLEAR MEDICINE NUCLEI ODD-EVEN NUCLEI ORGANS RADIOIMMUNOLOGY RADIOIMMUNOTHERAPY RADIOISOTOPES Radioisotopes - pharmacokinetics Radioisotopes - therapeutic use RADIOLOGY RADIOLOGY AND NUCLEAR MEDICINE RADIOTHERAPY Radiotherapy Dosage RARE EARTH ISOTOPES RARE EARTH NUCLEI RODENTS SURVIVAL CURVES THERAPEUTIC USES THERAPY TISSUE DISTRIBUTION Tumor Cells, Cultured USES VERTEBRATES
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