Rapid Hypertensinogenic Effect of Lead: Studies in the Spontaneously Hypertensive Rat

Chronic lead exposure may cause hypertension in normotensive rats. This hypertensinogenic effect has been attributed to perturbations in the renin-angiotensin axis, the contractile resporase of the vascular smooth muscle, or the intracellular Ca2+ homeostasis as a consequence of the inhibition of Na...

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Veröffentlicht in:	Toxicology and industrial health 1992-01, Vol.8 (1-2), p.89-102
Hauptverfasser:	Nakhoul, Farid, Kayne, Laurie H., Brautbar, Nachman, Hu, Ming-Shu, Mcdonough, Alicia, Eggena, Peter, Golub, Michael S., Berger, Morris, Chang, Chwen-Tzuei, Jamgotchian, Nora, Lee, David B.N.
Format:	Artikel
Sprache:	eng
Schlagworte:	560300 - Chemicals Metabolism & Toxicology ACID ANHYDRASES ANIMALS ATP-ASE BLOOD PRESSURE Body Weight CARDIOVASCULAR DISEASES CHRONIC EXPOSURE DISEASES ELEMENTS ENVIRONMENTAL EXPOSURE ENZYMES Femoral Artery - physiology HYDROLASES HYPERTENSION Hypertension - chemically induced LEAD Lead - blood Lead - toxicity Lead - urine Male MAMMALS METALS NONSPECIFIC PEPTIDASES ORGANIC COMPOUNDS PATHOGENESIS PEPTIDE HYDROLASES PHOSPHOHYDROLASES PROTEINS RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RATS Rats, Inbred SHR RENIN Renin - metabolism RODENTS SYMPTOMS TOXICITY VASCULAR DISEASES VERTEBRATES
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